A peptide-based medical device for the selective removal of inflammatory factors from the blood of people with sepsis. [PDF]
Commun Med (Lond)Cappello G +10 more
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Acetylcholine Reduces Monomeric C-Reactive Protein Pro-Inflammatory Activity
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Monomeric C-reactive protein regulates fibronectin mediated monocyte adhesion
Molecular Immunology, 2020The acute phase reactant C-reactive protein (CRP) binds with high affinity to fibronectin (FN), but this binding occurs only at pH 6.5 or lower, and the binding is inhibited by calcium ions at physiological pH. Since CRP in the circulating blood exists in a calcium-binding form, the interaction between CRP and FN in vivo has been uncertain.
Naeem, Ullah +8 more
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Anti-Monomeric C-Reactive Protein Antibody Ameliorates Arthritis and Nephritis in Mice
The Journal of Immunology, 2021Abstract Conformation-specific Ags are ideal targets for mAb-based immunotherapy. Here, we demonstrate that the monomeric form of C-reactive protein (mCRP) is a specific therapeutic target for arthritis and nephritis in a murine model. Screening of >1800 anti-mCRP mAb clones identified 3C as a clone recognizing the monomeric, but ...
Chitose Fujita +5 more
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Two-dimensional crystallization of rabbit C-reactive protein monomeric subunits
Acta Crystallographica Section D Biological Crystallography, 2003C-reactive protein (CRP) is one of the most characteristic acute-phase proteins. Modified CRP is the monomeric form of native CRP and has recently been suggested to exist under physiological conditions. In the current work, CRP subunits were separated from stock CRP solution by size-exclusion chromatography.
Yi, Wu +3 more
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Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes
Laboratory Investigation, 2021C-reactive protein (CRP) is an acute-phase protein that is used as an established biomarker to follow disease severity and progression in a plethora of inflammatory diseases. However, its pathophysiologic mechanisms of action are still poorly defined and remain elusive. CRP, in its pentameric form, exhibits weak anti-inflammatory activity.
Clara Ruiz-Fernández +12 more
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Monomeric C‐reactive protein modulates classic complement activation on necrotic cells
The FASEB Journal, 2011ABSTRACT The acute‐phase protein C‐reactive protein (CRP) recruits C1q to the surface of damaged cells and thereby initiates complement activation. However, CRP also recruits complement inhibitors, such as C4b‐binding protein (C4bp) and factor H, which both block complement progression at the level of C3 and ...
Mihlan, M. +7 more
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Monomeric C-reactive protein alters fibrin clot properties on endothelial cells
Thrombosis Research, 2012Elevated plasma levels of C-reactive protein (CRP) are independently associated with increased risk of atherothrombosis. Several lines of evidence suggest that CRP has prothrombogenic effects on injured vessel wall(s) by enhancing tissue factor (TF) expression. Abnormal fibrin formation is correlated with increased thrombotic risk.
Rong, Li +6 more
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Antibodies against monomeric C-reactive protein – a promising biomarker of lupus nephritis?
Clinical Biochemistry, 2017A significant incidence of systemic lupus erythematosus (SLE), the severity of lupus nephritis and varying responses to treatment rationalize the search for novel biomarkers of disease activity. The aim of the study was to assess whether antibodies against monomeric C reactive protein (anti-mCRP) are associated with the presence of lupus nephritis ...
Katarzyna Jakuszko +7 more
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Monomeric C-reactive protein evokes TCR Signaling-dependent bystander activation of CD4+ T cells
Molecular Immunology, 2023Bystander activation of T cells is defined as induction of effector responses by innate cytokines in the absence of cognate antigens and independent of T cell receptor (TCR) signaling. Here we show that C-reactive protein (CRP), a soluble pattern-recognition receptor assembled noncovalently by five identical subunits, can instead trigger bystander ...
Liang, Zhou +12 more
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