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FUNCTIONAL ACTIVITY OF MONOMERIC C-REACTIVE PROTEIN IN INTERVERTEBRAL DISC
Orthopaedic ProceedingsMonomeric C reactive protein (mCRP) presents important proinflammatory effects in endothelial cells, leukocytes, or chondrocytes. However, CRP in its pentameric form exhibits weak anti-inflammatory activity. It is used as a biomarker to follow severity and progression in infectious or inflammatory diseases, such as intervertebral disc degeneration ...
C. Ruiz-Fernández +8 more
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Conversion of native oligomeric to a modified monomeric form of human C-reactive protein
The International Journal of Biochemistry & Cell Biology, 1998C-reactive protein (CRP) is a pentameric oligoprotein composed of identical 23 kD subunits which can be modified by urea-chelation treatment to a form resembling the free subunit termed modified CRP (mCRP). mCRP has distinct physicochemical, antigenic, and biologic activities compared to CRP. The conditions under which CRP is converted to mCRP, and the
J J, Kresl, L A, Potempa, B E, Anderson
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Current Pharmaceutical Design, 2020
C-reactive Protein (CRP) is an acute phase reactant, belonging to the pentraxin family of proteins. Its level rises up to 1000-fold in response to acute inflammation. High sensitivity CRP level is utilized as an independent biomarker of inflammation and cardiovascular disease. The accumulating data suggests that CRP has two distinct forms.
Ivan S, Melnikov +5 more
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C-reactive Protein (CRP) is an acute phase reactant, belonging to the pentraxin family of proteins. Its level rises up to 1000-fold in response to acute inflammation. High sensitivity CRP level is utilized as an independent biomarker of inflammation and cardiovascular disease. The accumulating data suggests that CRP has two distinct forms.
Ivan S, Melnikov +5 more
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The FASEB Journal, 2009
ABSTRACT Emerging evidence indicates that in addition to native pentameric C‐reactive protein (CRP), monomeric CRP (mCRP) also plays an active role in inflammation associated with cardiovascular diseases. mCRP activates endothelial cells, one of the critical events in cardiovascular diseases;however, the ...
Shang-Rong, Ji +8 more
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ABSTRACT Emerging evidence indicates that in addition to native pentameric C‐reactive protein (CRP), monomeric CRP (mCRP) also plays an active role in inflammation associated with cardiovascular diseases. mCRP activates endothelial cells, one of the critical events in cardiovascular diseases;however, the ...
Shang-Rong, Ji +8 more
openaire +2 more sources
The contemporary management of cancers of the sinonasal tract in adults
Ca-A Cancer Journal for Clinicians, 2023Rajat Thawani
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PROTAC targeted protein degraders: the past is prologue
Nature Reviews Drug Discovery, 2022Miklos Bekes +2 more
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Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
Nature Reviews Molecular Cell Biology, 2021Simon Alberti, Anthony A Hyman
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Mechanisms, regulation and functions of the unfolded protein response
Nature Reviews Molecular Cell Biology, 2020Claudio Hetz +2 more
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Modulation of cellular processes by histone and non-histone protein acetylation
Nature Reviews Molecular Cell Biology, 2022Maria Shvedunova, Asifa Akhtar
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Treatment of renal cell carcinoma: Current status and future directions
Ca-A Cancer Journal for Clinicians, 2017Pedro Coelho Barata, Brian I Rini
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