Results 31 to 40 of about 5,891 (174)
Release of platelet constituents by monosodium urate crystals. [PDF]
Journal of Clinical Investigation, 1977 The release of human platelet constituents by the etiologic agent of gout, the monosodium urate crystal, is described here. In suspensions of washed platelets, response to urate crystals proceeded in two phases: A secretory phase involved the rapid active release of serotonin, ATP, and ADP with little loss of lactic dehydrogenase or beta-glucuronidase.
M H, Ginsberg +3 more
openaire +2 more sources
Effect of Methylxanthines on Urate Crystallization: In Vitro Models of Gout and Renal Calculi
CrystalsBackground: Common forms of pathological crystals are uric acid or urates, which are responsible for gout, urolithiasis, and other conditions. Methods: We used a kinetic–turbidimetric crystallization assay to evaluate the effect of ten specific ...
Jaume Dietrich +2 more
doaj +1 more source
Case Report: Articular Gout in Four Dogs and One Cat
Frontiers in Veterinary Science, 2022 BackgroundThere is widespread prejudice in veterinary medicine that gout does not occur in non-human mammalians. However, we recently discovered monosodium urate crystals in the synovial fluid obtained from a few dogs and a cat.
Hyo-Sung Kim +7 more
doaj +1 more source
Plasma Protein Binding by Monosodium Urate Crystals [PDF]
Arthritis & Rheumatism, 1983 AbstractUsing 2‐dimensional O'Farrell gel electrophoresis, we have mapped the proteins from undiluted plasma and serum which bind to monosodium urate (MSU) crystals. More than 30 crystal‐associated polypeptides were visualized, including anionic and cationic species.
Robert Terkeltaub +3 more
openaire +1 more source
Arthritis Care &Research, EarlyView.Objective Although the definition of a gout flare is well established, the state of gout flare resolution has not yet been defined. This study aimed to explore patients’ experiences and perceptions of gout flare resolution. Methods Semistructured interviews were conducted with 24 people with gout, guided by open‐ended questions exploring their ...
Sarah Stewart +5 more
wiley +1 more source
Monoarticular Crystal Arthropathy of the Knee: Tophaceous Gout
Dubai Medical Journal, 2021 Tophaceous gout is a crystal arthropathy and a disorder of purine metabolism characterized by monosodium urate crystal deposition. A case of tophaceous gout of the knee joint in a 30-year-old female is reported, and the imaging appearances on high ...
Ravikanth Reddy
doaj +1 more source
Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout
Arthritis Care &Research, EarlyView.Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo +6 more
wiley +1 more source
Images in medicine - Gouty arthritis
Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2018 Gout is a disorder of uric acid metabolism, characterised by deposition of monosodium urate crystals in joints and periarticular soft tissues as well as renal calculi and chronic nephropathy.
Shalaka Suresh Shinde +3 more
doaj +1 more source
International Journal of Medical Biochemistry, 2022 INTRODUCTION: Gout is a common and easily treated disease characterized by the accumulation of monosodium urate crystals in both joints and other tissues.
Ahmet Rıfat Balık +8 more
doaj +1 more source
Advanced Science, EarlyView.The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang +15 more
wiley +1 more source