Results 11 to 20 of about 22,920 (247)

Inflammatory modulation of the response of bronchial epithelial cells to lipopolysaccharide with pretreatment by montelukast [PDF]

Kragujevac Journal of Science, 2022
Montelukast, a leukotriene receptor antagonist, is the most prescribed nonsteroidal anti-inflammatory drug used as an add-on therapy for asthma. Besides its effect on blocking leukotriene action, montelukast has been proposed to have secondary anti ...
Jendrišek Gorana, Nikolić Aleksandra, Dragičević Sandra   +2 more
doaj   +1 more source

A systematic review and meta-analysis of loratadine combined with montelukast for the treatment of allergic rhinitis

Frontiers in Pharmacology, 2023
Background: Loratadine and montelukast are clinical first-line drugs in the treatment of allergic rhinitis (AR). However, there is no clear evidence of the efficacy of loratadine combined with montelukast in the treatment of AR.
Huan Wang, Huan Wang, Qing Ji, Chao Liao, Li Tian   +4 more
doaj   +1 more source

Montelukast does not increase the risk of attention-deficit/hyperactivity disorder in pediatric asthma patients: A nationwide population-based matched cohort study

Journal of the Formosan Medical Association, 2021
Background: Attention-deficit/hyperactivity disorder (ADHD) has been linked to pediatric asthma patients treated with montelukast. This study is the first to use a nationwide health insurance research database (NHIRD) to study whether asthmatic children ...
Po-Yu Huang, Yao-Hsu Yang, Ying-Hua Huang, Ho-Chang Kuo, Liang-Jen Wang, Shao-Ju Chien, Ling-Sai Chang   +6 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Neuropsychiatric Adverse Events of Montelukast: An Analysis of Real-World Datasets and drug−gene Interaction Network

Frontiers in Pharmacology, 2021
Montelukast is a selective leukotriene receptor antagonist that is widely used to treat bronchial asthma and nasal allergy. To clarify the association between montelukast and neuropsychiatric adverse events (AEs), we evaluated case reports recorded ...
Ryogo Umetsu, Mizuki Tanaka, Yoko Nakayama, Yamato Kato, Natsumi Ueda, Yuri Nishibata, Shiori Hasegawa, Kiyoka Matsumoto, Noriaki Takeyama, Kazuhiro Iguchi, Hiroyuki Tanaka, Eiichi Hinoi, Eiichi Hinoi, Naoki Inagaki, Masatoshi Inden, Yoshinori Muto, Mitsuhiro Nakamura   +16 more
doaj   +1 more source

Development and Validation of Montelukast with Grape/Licorice Juices and its Application to Pharmacokinetic Studies by LC/MS

Indonesian Journal of Pharmacy, 2020
A simple, rapid and sensitive simultaneous method for validation and determination of Montelukast in rat plasma in the presence of grape and licorice juices has been done by using High Performance Liquid Chromatography–Mass Spectrometry (HPLC/MS).
Mohammed Hamad, Rafif Raad, Eyad Mallah, Zainab Zakaria, Tawfiq Arafat, Wael Abu Dayyih   +5 more
doaj   +1 more source

Effects of Montelukast on Arsenic-Induced Epithelial-Mesenchymal Transition and the Role of Reactive Oxygen Species Production in Human Bronchial Epithelial Cells

Frontiers in Pharmacology, 2022
Background: Epithelial-mesenchymal transition (EMT) of airway lung epithelial cells is considered a major driver of fibrosis and airway remodeling. Arsenic exposure is well known to cause the malignant transformation of cells, including those in the lung.
Huang-Chi Chen, Huang-Chi Chen, Hsin-Ying Clair Chiou, Hsin-Ying Clair Chiou, Mei-Lan Tsai, Mei-Lan Tsai, Szu-Chia Chen, Szu-Chia Chen, Szu-Chia Chen, Ming-Hong Lin, Ming-Hong Lin, Ming-Hong Lin, Ming-Hong Lin, Tzu-Chun Chuang, Chih-Hsing Hung, Chih-Hsing Hung, Chih-Hsing Hung, Chih-Hsing Hung, Chao-Hung Kuo, Chao-Hung Kuo, Chao-Hung Kuo   +20 more
doaj   +1 more source

Pediatric Asthma: Where Has Montelukast Gone?

Applied Sciences, 2023
At its introduction in the management of pediatric asthma, montelukast was regarded as a potentially revolutionary drug due to its mechanism of action and easy clinical applicability.
Marco Maglione, Antonietta Giannattasio, Antonia Pascarella, Vincenzo Tipo   +3 more
doaj   +1 more source

The effect of montelukast, a leukotriene receptor antagonist, on the acetic acid-induced model of colitis in rats: Involvement of NO-cGMP-KATP channels pathway

Frontiers in Pharmacology, 2022
Inflammatory bowel disease is a chronic autoimmune disorder that may involve entire gastrointestinal tract. The leukotrienes have a role as mediators in the pathophysiology of colitis. Here, we investigated the effect of a leukotriene receptor antagonist,
Behnam Ghorbanzadeh, Mohammad Amin Behmanesh, Roya Mahmoudinejad, Mehdi Zamaniyan, Shadi Ekhtiar, Yousef Paridar   +5 more
doaj   +1 more source

Tailored second line therapy in asthmatic children with the arginine-16 genotype [PDF]

, 2012
The arginine-16 beta-2 receptor genotype confers increased susceptibility to exacerbations in asthmatic children taking regular long acting beta-2 agonists.
Aziz, Basu, Bateman, Bleecker, Brian J. Lipworth, British Thoracic Society, Colin N. A. Palmer, Currie, Donald F. Macgregor, Drysdale, Fuhlbrigge, Hall, Helen P. Donald, Joos, Juniper, Kaninika Basu, Kramer, Lee, Lemanske, Liggett, Lipworth, Martinez, Palmer, Roger Tavendale, Simon A. Ogston, Somnath Mukhopadhyay, Wechsler, Wilson   +27 more
core   +1 more source