Results 21 to 30 of about 27,891 (280)

Risk of neuropsychiatric adverse events associated with montelukast use in children and adolescents: a population-based case-crossover study [PDF]

BMJ Paediatrics Open
Purpose Montelukast is used extensively in children and adolescents for allergic rhinitis and asthma. However, concerns have been raised regarding the increased risk of neuropsychiatric adverse events (NPAEs) associated with montelukast use.
Ju-Young Shin, Jae Won Kim, Mideum Kim, Min Sook Seo   +3 more
doaj   +2 more sources

Inflammatory modulation of the response of bronchial epithelial cells to lipopolysaccharide with pretreatment by montelukast [PDF]

Kragujevac Journal of Science, 2022
Montelukast, a leukotriene receptor antagonist, is the most prescribed nonsteroidal anti-inflammatory drug used as an add-on therapy for asthma. Besides its effect on blocking leukotriene action, montelukast has been proposed to have secondary anti ...
Jendrišek Gorana, Nikolić Aleksandra, Dragičević Sandra   +2 more
doaj   +1 more source

Efficacy and safety of montelukast adjuvant therapy in adults with cough variant asthma: A systematic review and meta‐analysis

Clinical Respiratory Journal, 2023
Montelukast is a highly selective and specific cysteinyl leukotriene receptor antagonist used in the treatment of asthma. Whether montelukast as adjuvant therapy can significantly and safely treat adults with cough variant asthma (CVA) remains ...
Qian Xu, Ting-ting Lu, Zhong-yang Song, Pengying Zhu, Y. Wu, Lumei Zhang, Kehu Yang, Zhiming Zhang   +7 more
semanticscholar   +1 more source

Analysis of Neuropsychiatric Diagnoses After Montelukast Initiation

JAMA Network Open, 2022
This cohort study investigates the association of montelukast treatment with adverse neuropsychiatric outcomes among patients with asthma or allergic rhinitis.
T. Paljarvi, J. Forton, S. Luciano, K. Herttua, S. Fazel   +4 more
semanticscholar   +1 more source

Montelukast and Acute Coronary Syndrome: The Endowed Drug

Pharmaceuticals, 2022
Acute coronary syndrome (ACS) is a set of signs and symptoms caused by a reduction of coronary blood flow with subsequent myocardial ischemia. ACS is associated with activation of the leukotriene (LT) pathway with subsequent releases of various LTs ...
B. Alomair, H. Al-kuraishy, A. Al-Gareeb, S. Al-Hamash, M. De Waard, J. Sabatier, H. Saad, Gaber El-Saber Batiha   +7 more
semanticscholar   +1 more source

Leukotrienes vs. Montelukast—Activity, Metabolism, and Toxicity Hints for Repurposing

Pharmaceuticals, 2022
Increasing environmental distress is associated with a growing asthma incidence; no treatments are available but montelukast (MTK)—an antagonist of the cysteinyl leukotrienes receptor 1—is widely used in the management of symptoms among adults and ...
Cátia F. Marques, M. M. Marques, G. Justino   +2 more
semanticscholar   +1 more source

The anti-inflammatory and antioxidant effects of Montelukast on lung sepsis in adult mice

Journal of Medicine and Life, 2022
One of the most complex clinical challenges facing medical practice is sepsis-induced lung dysfunction resulting from polymicrobial sepsis. Although many therapeutic approaches have been used in such clinical challenges, there is still further need for a
Zainab Ali Alnfakh, D. H. Al-Mudhafar, Rana Talib Al-Nafakh, A. Jasim, N. Hadi   +4 more
semanticscholar   +1 more source

Development and Validation of Montelukast with Grape/Licorice Juices and its Application to Pharmacokinetic Studies by LC/MS

Indonesian Journal of Pharmacy, 2020
A simple, rapid and sensitive simultaneous method for validation and determination of Montelukast in rat plasma in the presence of grape and licorice juices has been done by using High Performance Liquid Chromatography–Mass Spectrometry (HPLC/MS).
Mohammed Hamad, Rafif Raad, Eyad Mallah, Zainab Zakaria, Tawfiq Arafat, Wael Abu Dayyih   +5 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Effects of treatment with montelukast alone, budesonide/formoterol alone and a combination of both in cough variant asthma

Respiratory Research, 2022
Background Whether cysteinyl-leukotriene receptor antagonists (LTRAs) have a similar antitussive effect to inhaled corticosteroids and long-acting β2-agonist (ICS/LABA), and that LTRA plus ICS/LABA is superior to LTRAs alone or ICS/LABA alone in treating
F. Yi, Chen Zhan, Baojuan Liu, Hu Li, Jianmeng Zhou, Jiaman Tang, Wen-hong Peng, Weihua Luo, Qiaoli Chen, K. Lai   +9 more
semanticscholar   +1 more source