Results 21 to 30 of about 1,649 (211)

A MOR Antagonist with High Potency and Antagonist Efficacy among Diastereomeric C9-Alkyl-Substituted N-Phenethyl-5-(3-hydroxy)phenylmorphans

open access: yesMolecules, 2023
The 5-(3-hydroxy)phenylmorphan structural class of compounds are unlike the classical morphinans, 4,5-epoxymorphinans, and 6,7-benzomorphans, in that they have an equatorially oriented aromatic ring rather than the axial orientation of that ring found in
Dana R. Chambers   +5 more
doaj   +1 more source

Doctor or drug dealer? International legal provisions for the legitimate handling of drugs of abuse [PDF]

open access: yes, 2020
© The Author(s) 2020. The final, definitive version of this paper has been published in: Gallagher, C. T., Atik, S. K., Isse, L., & Mann, S. K. (2020). Doctor or drug dealer?
Atik, Sanaa   +3 more
core   +2 more sources

The first synthesis of 3-deoxyoripavine and its utilization in the preparation of 10-deoxyaporphines and cyprodime [PDF]

open access: yes, 2013
The synthesis of 3-deoxyoripavine (7) was realized as a novel and promising intermediate towards the synthesis of the important class of dopaminergic and/or serotonergic 10- deoxyaporphines and the special pharmacological tool µ opioid antagonist ...
Berényi, Sándor   +3 more
core   +1 more source

Carfentanil is a β‐arrestin‐biased agonist at the μ opioid receptor

open access: yesBritish Journal of Pharmacology, Volume 180, Issue 18, Page 2341-2360, September 2023., 2023
Abstract Background and Purpose The illicit use of fentanyl‐like drugs (fentanyls), which are μ opioid receptor agonists, and the many overdose deaths that result, has become a major problem. Fentanyls are very potent in vivo, leading to respiratory depression and death.
Nokomis Ramos‐Gonzalez   +7 more
wiley   +1 more source

Liquid Chromatography Coupled with Linear Ion Trap Hybrid OrbitrapMass Spectrometry for Determination of Alkaloids in Sinomeniumacutum

open access: yesMolecules, 2018
The characterization of alkaloids is challenging because of the diversity of structures and the complicated fragmentation of collision induced structural dissociation in mass spectrometry.
Jinjun Shan   +7 more
doaj   +1 more source

Pharmacological Investigations of N-Substituent Variation in Morphine and Oxymorphone: Opioid Receptor Binding, Signaling and Antinociceptive Activity [PDF]

open access: yes, 2014
Morphine and structurally related derivatives are highly effective analgesics, and the mainstay in the medical management of moderate to severe pain.
A Manglik   +42 more
core   +3 more sources

Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord

open access: yesNeurobiology of Disease, 2011
Dextromethorphan (DM) is a dextrorotary morphinan and a widely used component of cough medicine. Relatively high doses of DM in combination with quinidine are used for the treatment of mood disorders for patients with multiple sclerosis (MS). However, at
Olga V. Chechneva   +5 more
doaj   +1 more source

Morphinanes isomères originaux isolés de Stephania zippeliana [PDF]

open access: yes, 1989
A côté de huit aporphinoïdes, six alcaloïdes possédant une structure de morphinane ont été isolés des parties aériennes de #Stephania zippeliana$ Miq.
Bruneton, J.   +3 more
core   +1 more source

Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism [PDF]

open access: yes, 2014
Indolopropellane 2 was reported to show almost no binding affinity to the δ opioid receptor (DOR) in spite of the fact that 2 has both the propellane fundamental skeleton (message part) with binding ability to the opioid receptors and a possible DOR ...
Fujii Hideaki   +10 more
core   +1 more source

Studies toward bivalent κ opioids derived from salvinorin A: heteromethylation of the furan ring reduces affinity

open access: yesBeilstein Journal of Organic Chemistry, 2013
The recent crystal structure of the κ-opioid receptor (κ-OR) revealed, unexpectedly, that the antagonist JDTic is a bivalent ligand: in addition to the orthosteric pocket occupied by morphinans, JDTic also occupies a distinct (allotopic) pocket ...
Thomas A. Munro   +4 more
doaj   +1 more source

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