Results 21 to 30 of about 68 (63)
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Enzymatic transformations of morphinane alkaloids
Phytochemistry, 1982Abstract Horseradish peroxidase transforms morphinane alkaloids into N-oxides and morphine to pseudomorphine in the presence of hydrogen peroxide. The crude poppy enzyme fraction shows the same activities. The rates of reactions were influenced by phenolic compounds and their relation controlled by the concentration of hydrogen peroxide and the ...
Mária Petz-Stifter, Dezsö Vágújfalvi
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ChemInform Abstract: Straightforward Assembly of the Octahydroisoquinoline Core of Morphinan Alkaloids. [PDF]
ChemInform, 2010 AbstractThe octahydroisoquinoline core of morphinan is prepared with high diastereoselectivity.
Dunet, Julie +4 more
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Reaction of morphinan-6,8-dienes with azadienophiles
Tetrahedron, 1996Reaction of various morphinan dienes, i.e. thebaine (la), N-demethyl-N- formylthebaine (lb), 6-demethoxythebaine (le), 13-dihydrothebaine (2a), 4-acetoxy-~-dihydrothebaine (2b), 7-chloro-6-demethoxythebaine (3a) and 7-bromo-6-demethoxythebaine (3b) with 4-phenyl-4H- 1,2,4-triazoline-3,5-dione (PTAD) gave rise to new Diels-Alder (DA) adducts.
Marton, János +5 more
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Synthesis of Sulfur-Containing Morphinane Dienes
Synthetic Communications, 1995AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Sándor Berényi +3 more
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Hydroxy‐morphinane. 7. Mitteilung. (−)‐3‐Hydroxy‐N‐allyl‐morphinan und verwandte Verbindungen
Helvetica Chimica Acta, 1956Abstract1‐(p‐Hydroxybenzyl)‐1, 2,3,4,5,6,7,8‐octahydro‐isoquinoline has been resolved into the optical antipodes, from which any desired optically active 3‐hydroxy‐morphinan substituted at the nitrogen atom can easily be obtained. The (‐)‐3‐hydroxy‐N‐allyl‐morphinan thus obtained as well as its ethers and ester counteract the effect of opiates and ...
A. Grüssner, O. Schnider, J. Hellerbach
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Aporphine and Morphinan Alkaloids
1968The aporphine and morphinan alkaloids can be conveniently considered together because they often occur together in the same plant, and also because in terms of structure they can both be derived from a benzylisoquinoline skeleton by additional ring closures:
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Diversified electrophysiological properties of morphinan drugs in rats
General Pharmacology: The Vascular System, 19911. In in vivo and in vitro studies in rats, the effects of dextromethorphan (DM), dextrorphan (DX), and levorphanol (LV) were compared with those induced by kappa and sigma opiate agonists. 2. In rat hippocampal slices all the morphinans were able to pertubate the CAI hippocampal synaptic transmission, while only DX and LV affected the N-methyl-D ...
A. Scotti de Carolis +3 more
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Hydroxy‐Morphinane. Mitteilung. Über ein Photooxydationsprodukt von (+)‐3‐Methoxy‐N‐methyl‐morphinan
Helvetica Chimica Acta, 1956AbstractPhotooxydation of (+)‐3‐methoxy‐N‐methyl‐morphinan hydrobromide (I, HBr, Romilar Roche) yields (−)‐3‐methoxy‐10‐oxo‐N‐methyl‐morphinan (II). The structure of the compound has been established. The introduction of a carbonyl group in position 10 is easily achieved in good yield also by oxydation with chromic acid. Whereas reduction of the 10‐oxo‐
O. Schnider +4 more
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Morphinan Neuroprotection: New Insight into the Therapy of Neurodegeneration
Critical Reviews™ in Neurobiology, 2004Neuro-inflammation plays a pivotal role in numerous neurodegenerative disorders, such as Parkinson's disease (PD). Traditional anti-inflammatory drugs have limited therapeutic use because of their narrow spectrum and severe side effects after long-term use. Morphinans are a class of compounds containing the basic morphine structure.
Jau-Shyong Hong +4 more
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Chemische Berichte, 1951
AbstractN‐Phenacetyl‐β‐cyclohexenyl‐äthylamin, welches sich nach Schnider und Hellerbach in die „Vorstufe”︁ und damit in Morphinan überführen läßt, wird auf einem neuen Wege auf der Basis von Cyclohexanon und Acetylen aufgebaut.
Heinrich Pohlmann +2 more
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AbstractN‐Phenacetyl‐β‐cyclohexenyl‐äthylamin, welches sich nach Schnider und Hellerbach in die „Vorstufe”︁ und damit in Morphinan überführen läßt, wird auf einem neuen Wege auf der Basis von Cyclohexanon und Acetylen aufgebaut.
Heinrich Pohlmann +2 more
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