Results 41 to 50 of about 339,726 (399)

Postmortem tissue distribution of morphine and its metabolites in a series of heroin related deaths [PDF]

, 2018
The abuse of heroin (diamorphine) and heroin deaths are growing around the world. The interpretation of the toxicological results from suspected heroin deaths is notoriously difficult especially in cases where there may be limited samples.
Beer, Lewis J., Crichton, Megan L., De Paoli, Giorgia, Drummond, Gail, Maskell, Peter D., Seetohul, L. Nitin, Wilson, Nathan E.   +6 more
core   +4 more sources

Context-dependent effects of the CB1 receptor antagonist rimonabant on morphine-induced behavioral sensitization in female mice

Frontiers in Pharmacology, 2023
Introduction: The endocannabinoid system has been implicated in the neurobiology of opioid use disorder. While the CB1 receptor antagonist rimonabant has been shown to block some of the behavioral effects of opioids, studies suggest that the treatment ...
Eduardo A. V. Marinho, Eduardo A. V. Marinho, Alexandre Justo Oliveira-Lima, Alexandre Justo Oliveira-Lima, Henrique S. Reis, Renan Santos-Baldaia, Raphael Wuo-Silva, Andre W. Hollais, Thais S. Yokoyama, Roberto Frussa-Filho, Lais F. Berro, Lais F. Berro, Lais F. Berro   +12 more
doaj   +1 more source

Randomized Trial of Low-Dose Morphine Versus Weak Opioids in Moderate Cancer Pain.

Journal of Clinical Oncology, 2016
PURPOSE The WHO guidelines on cancer pain management recommend a sequential three-step analgesic ladder. However, conclusive data are lacking as to whether moderate pain should be treated with either step II weak opioids or low-dose step III strong ...
E. Bandieri, M. Romero, C. Ripamonti, F. Artioli, D. Sichetti, C. Fanizza, D. Santini, L. Cavanna, B. Melotti, P. Conte, F. Roila, S. Cascinu, E. Bruera, G. Tognoni, M. Luppi   +14 more
semanticscholar   +1 more source

The effectiveness of Patient Controlled Analgesia (PCA) morphine-ketamine compared to Patient Controlled Analgesia (PCA) morphine to reduce total dose of morphine and Visual Analog Scale (VAS) in postoperative laparotomy surgery

Bali Journal of Anesthesiology, 2017
Background: Laparotomy may cause moderate to severe after surgery pain, thus adequate pain management is needed. The addition of ketamine in patient controlled analgesia (PCA) morphine after surgery can be the option.
I Gusti Ngurah Mahaalit Aribawa, Tjokorda Gde Agung Senapathi, Made Wiryana, I Ketut Sinardja, I Gede Budiarta, I Made Gede Widnyana, I Wayan Aryabiantara, Pontisomaya Parami, Pande Nyoman Kurniasari, Adinda Putra Pradhana   +9 more
doaj   +1 more source

Effects of spatially heterogeneous lakeside development on nearshore biotic communities in a large, deep, oligotrophic lake

Limnology and Oceanography, Volume 67, Issue 12, Page 2649-2664, December 2022., 2022
Abstract Sewage released from lakeside development can reshape ecological communities. Nearshore periphyton can rapidly assimilate sewage‐associated nutrients, leading to increases of filamentous algal abundance, thus altering both food abundance and quality for grazers.
Michael F. Meyer, Ted Ozersky, Kara H. Woo, Kirill Shchapov, Aaron W. E. Galloway, Julie B. Schram, Emma J. Rosi, Daniel D. Snow, Maxim A. Timofeyev, Dmitry Yu. Karnaukhov, Matthew R. Brousil, Stephanie E. Hampton   +11 more
wiley   +1 more source

PSYCHOSIS OF MORPHINISM. [PDF]

JAMA: The Journal of the American Medical Association, 1905
All writers have mentioned the general defective conception of truth and the relation of right and wrong which appears to be a prominent symptom in all persons who use morphia. It is difficult to understand whether this is a veritable paralysis of the higher reasoning centers or a defect of the senses by which distorted conceptions of facts are not ...
openaire   +3 more sources

Morphine is not a prodrug [PDF]

British Journal of Anaesthesia, 2015
Editor–A prodrug is defined as a medication that is administered in an inactive or less than fully active form and is then converted to its active form through a normal metabolic process (http://en. wikipedia.org/wiki/Prodrug). The title of a recent publication in the British Journal of Analgesia, ‘Morphine-6-glucuronide is responsible for the ...
J. Loetsch, A. Dahan
openaire   +2 more sources

Significance of Metabolite Ratios in the Interpretation of Segmental Hair Testing Results—Differentiation of Single from Chronic Morphine Use in a Case Series

Metabolites, 2021
In morphine intoxication cases, forensic toxicologists are frequently confronted with the question of if the individual was opioid-tolerant or opioid-naïve, which can be investigated by hair analysis. However, interpretation of results can be challenging.
Milena M. Madry, Sandra N. Poetzsch, Andrea E. Steuer, Thomas Kraemer, Markus R. Baumgartner   +4 more
doaj   +1 more source

Opioid regulation of Mu receptor internalisation: relevance to the development of tolerance and dependence [PDF]

, 2010
Internalisation of the mu opioid receptor from the surface of cells is generally achieved by receptor occupancy with agonist ligands of high efficacy. However, in many situations the potent analgesic morphine fails to promote internalisation effectively ...
Lopez-Gimenez, J.F., Milligan, G.
core   +2 more sources

Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

Scientific Reports, 2015
Cell-derived exosomes have been demonstrated to be efficient carriers of small RNAs to neighbouring or distant cells, highlighting the preponderance of exosomes as carriers for gene therapy over other artificial delivery tools.
Yuchen Liu, Dameng Li, Zhengya Liu, Yu Zhou, Danping Chu, Xihan Li, Xiaohong Jiang, Dongxia Hou, X. Chen, Yuda Chen, Zhanzhao Yang, Ling Jin, Waner Jiang, Chenfei Tian, Geyu Zhou, Ke Zen, Junfeng Zhang, Yujing Zhang, Jing Li, Chen-Yu Zhang   +19 more
semanticscholar   +1 more source