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PSYCHOSIS OF MORPHINISM. [PDF]
JAMA: The Journal of the American Medical Association, 1905 All writers have mentioned the general defective conception of truth and the relation of right and wrong which appears to be a prominent symptom in all persons who use morphia. It is difficult to understand whether this is a veritable paralysis of the higher reasoning centers or a defect of the senses by which distorted conceptions of facts are not ...
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Journal of Neuroscience, 2017 Although morphine remains the primary drug prescribed for alleviation of severe or persistent pain, both preclinical and clinical studies have shown that females require two to three times more morphine than males to produce comparable levels of ...
Hillary H. Doyle +3 more
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Translational Psychiatry, 2022 The present study investigates the possible therapeutic effects of human mesenchymal stem cell-derived secretome on morphine dependence and relapse. This was studied in a new model of chronic voluntary morphine intake in Wistar rats which shows classic ...
María Elena Quintanilla +8 more
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Morphine is not a prodrug [PDF]
British Journal of Anaesthesia, 2015 Editor–A prodrug is defined as a medication that is administered in an inactive or less than fully active form and is then converted to its active form through a normal metabolic process (http://en. wikipedia.org/wiki/Prodrug). The title of a recent publication in the British Journal of Analgesia, ‘Morphine-6-glucuronide is responsible for the ...
J. Loetsch, A. Dahan
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Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse
Scientific Reports, 2015 Cell-derived exosomes have been demonstrated to be efficient carriers of small RNAs to neighbouring or distant cells, highlighting the preponderance of exosomes as carriers for gene therapy over other artificial delivery tools.
Yuchen Liu +19 more
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Brain Reward Circuits in Morphine Addiction
Molecules and Cells, 2016 Morphine is the most potent analgesic for chronic pain, but its clinical use has been limited by the opiate’s innate tendency to produce tolerance, severe withdrawal symptoms and rewarding properties with a high risk of relapse.
Juhwan Kim +4 more
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Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation
Journal of Neuroinflammation, 2016 BackgroundTolerance seriously impedes the application of morphine in clinical medicine. Thus, it is necessary to investigate the exact mechanisms and efficient treatment.
Yinbing Pan +9 more
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Morphine promotes cancer stem cell properties, contributing to chemoresistance in breast cancer
OncoTarget, 2015 Morphine is an opioid analgesic drug commonly used for pain relief in cancer patients. Here, we report that morphine enhances the mammosphere forming capacity and increases the expression of stemness-related transcription factors Oct4, Sox2 and Nanog ...
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Metabolites, 2021 In morphine intoxication cases, forensic toxicologists are frequently confronted with the question of if the individual was opioid-tolerant or opioid-naïve, which can be investigated by hair analysis. However, interpretation of results can be challenging.
Milena M. Madry +4 more
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Morphine Promotes Tumor Angiogenesis and Increases Breast Cancer Progression
BioMed Research International, 2015 Morphine is considered a highly potent analgesic agent used to relieve suffering of patients with cancer. Several in vitro and in vivo studies showed that morphine also modulates angiogenesis and regulates tumour cell growth.
S. Bimonte +7 more
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