Results 51 to 60 of about 270,592 (355)
A new spin on chemotaxonomy: Using non‐proteogenic amino acids as a test case
Applications in Plant Sciences, EarlyView.Abstract Premise Specialized metabolites serve various roles for plants and humans. Unlike core metabolites, specialized metabolites are restricted to certain plant lineages; thus, in addition to their ecological functions, specialized metabolites can serve as diagnostic markers of plant lineages.
Makenzie Gibson +4 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim This study aims to conduct a hypothesis‐generating screening for acute cardiovascular effects of prescription medications. Methods This Danish nationwide screening study was conducted among incident cases of cardiovascular diseases, including myocardial infarction (MI), ischemic stroke (IS), heart failure (HF), venous thromboembolism (VTE),
Saad Hanif Abbasi +4 more
wiley +1 more source
Journal of the Formosan Medical Association, 2016 We previously showed that subsequent intrathecal (i.t.) injection of resveratrol (30 μg) significantly reverses morphine-evoked neuroinflammation in morphine-tolerant rats. The present study examined the underlying mechanism.
Ru-Yin Tsai +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Morphine is widely used in the treatment of moderate to severe pain. Long-term use of morphine leads to various adverse effects, such as tolerance and hyperalgesia.
Liqiong He +12 more
doaj +1 more source
Comparison of morphine and morphine with ketamine for postoperative analgesia [PDF]
Canadian Journal of Anaesthesia, 1996 The purpose of this study was to compare morphine with ketamine to morphine alone in a double-blind investigation of postsurgical pain control.Forty-two ASA 1 and 2 patients undergoing elective microdiscectomy were administered either 1 mg.ml-1 of morphine (n = 20) or 1 mg.ml-1 of both morphine and ketamine (n = 22) via iv patient controlled analgesia (
Keith B. Javery +3 more
openaire +3 more sources
Dopamine D4 receptor activation counteracts nigrostriatal pathway activation by morphine: relevance in drug addiction. [PDF]
, 2013 Morphine induces dopamine release in the caudate putamen (CPu), which promotes stereotyped behavior and habit learning for drug-seeking and –taking. Nigrostriatal pathway stimulation by morphine is due to a removal of tonic inhibition arising from SNr ...
De-la-Calle-Martin, Adelaida +7 more
core
Trends in gabapentinoid prescribing: A nationwide Danish drug utilization study
British Journal of Clinical Pharmacology, EarlyView.Aims Pregabalin and gabapentin are increasingly used for pain and other conditions. Concerns exist about overuse as well as potential misuse and abuse. To guide rational prescribing practices, we provide detailed nationwide data on the use of gabapentinoids in Denmark.
Anton Pottegård +7 more
wiley +1 more source
Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine
iScience, 2021 Summary: Morphine is commonly used to relieve moderate to severe pain, but repeated doses cause opioid tolerance. Here, we used ATP sensor and fiber photometry to detect prefrontal ATP level.
Yeting Zeng +7 more
doaj