Results 81 to 90 of about 303,149 (361)

BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates [PDF]

, 2019
© 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have
Cami-Kobeci, Gerta, Czoty, Paul W., DeLoid, Heather B., Ding, Huiping, Hsu, Fang Chi, Husbands, Stephen M., Kiguchi, Norikazu, Ko, Mei Chuan, Sukhtankar, Devki D., Toll, Lawrence   +9 more
core   +4 more sources

Carum carvi and Ormenis multicaulis Extracts: Chemical Analysis and In Vivo Experiments to Evaluate the Synergistic Analgesic and Anti‐Inflammatory Effects

Chemistry &Biodiversity, EarlyView.
ABSTRACT The purpose of the present investigation was to determine the effects of combination of Ormenis multicaulis dry flower methanolic extracts and Carum carvi seed methanolic extracts on pain and inflammation, compared to their use separately. High‐performance liquid chromatography (HPLC) analysis of methanolic extracts showed the presence of ...
El Mahdi Wakrim, Karima Raoui, Hamid Kabdy, Jawad Laadraoui, Mehdi Ait Laaradia, Chafik Terrafe, Sami Mnif, Brahim Bouizgarne, Stefania Garzoli, Abderrahman Chait   +9 more
wiley   +1 more source

Antibiotic-Driven Gut Microbiome Disorder Alters the Effects of Sinomenine on Morphine-Dependent Zebrafish

Frontiers in Microbiology, 2020
Morphine is one of the most severely abused drugs in the world. Previous research on morphine addiction has focused on the central nervous system (CNS). Studies have shown that a two-way regulation of the brain and gut microbiota (GM), suggesting a link ...
Zhu Chen, Chen Zhijie, Zhou Yuting, Xiao Shilin, Zhou Qichun, Ou Jinying, Luo Chaohua, Li Jing, Mo Zhixian   +8 more
doaj   +1 more source

Novel Insights Into the Bioactive Profile and Therapeutic Potentials of Indonesian Annona muricata Leaves

Chemistry &Biodiversity, EarlyView.
Pharmacological investigation of the aqueous extract of Annona muricata L. leaves from Indonesia. ABSTRACT This study investigates, for the first time, the comprehensive pharmacological profile of the aqueous extract of Annona muricata L. (graviola) leaves from Indonesia, focusing on its antioxidant, antinociceptive, and anti‐inflammatory properties ...
Sara Oufquir, Fatimazahra Agouram, Hamid Kabdy, Mehdi Ait Laaradia, Khadija Oubella, Baslam Abdelmoniim, Aboufatima Rachida, Stefania Garzoli, Abderrahman Chait   +8 more
wiley   +1 more source

Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma. [PDF]

, 2020
Despite the large comorbidity between PTSD and opioid use disorders, as well as the common treatment of physical injuries resulting from trauma with opioids, the ability of opioid treatments to subsequently modify PTSD-related behavior has not been well ...
Evans, Christopher J, Fanselow, Michael S, Li, Kevin, Pennington, Zachary T, Rajbhandari, Abha K, Trott, Jeremy M, Walwyn, Wendy M   +6 more
core   +1 more source

Opioid and Nitrergic Pathways Mediate Antinociception by Pectis elongata Kunth. Essential Oil

Chemistry &Biodiversity, EarlyView.
ABSTRACT In the present study, we aimed to evaluate the antinociceptive potential of the Pectis elongata essential oil (PeEO) and to understand its mechanism of action by identifying possible pain inhibition pathways. PeEO was analyzed using gas chromatography coupled with mass spectrometry.
Angela Palma Amorin, Sandra Layse Ferreira Sarrazin, Leomara Andrade da Silva, Thaiana Neves Coelho, Adriele Pantoja Cunha, Vitória Albuquerque de Lima, Domingas Machado da Silva, Pablo Luis Baia Figueiredo, Ricardo Bezerra de Oliveira   +8 more
wiley   +1 more source

Cofactor regeneration by a soluble pyridine nucleotide transhydrogenase for biological production of hydromorphone [PDF]

, 2000
We have applied the soluble pyridine nucleotide transhydrogenase of Pseudomonas fluorescens to a cell-free system for the regeneration of the nicotinamide cofactors NAD and NADP in the biological production of the important semisynthetic opiate drug ...
Boonstra, B, Bruce, N C, French, C E, Rathbone, D A, Walker, E H   +4 more
core   +2 more sources

Cobalamin‐Dependent Aryl Methyl Ether O‐Demethylases: Promising Enzymes for Biocatalytic Applications from Lignin Valorization to Organic Synthesis

ChemCatChem, EarlyView.
Cobalamin‐dependent aryl methyl ether O‐demethylases have high potential for biocatalytic applications, including lignin valorization and synthetic chemistry. In this review, we provide a detailed overview of such O‐demethylase systems identified to date from various microorganisms, including their mechanism, substrate scope and selectivity, and ...
Niels Krabbe Johnsen, Santipap Chaiyasarn, Zheng Guo, Jaehong Han, Bekir Engin Eser   +4 more
wiley   +1 more source

PKC-Mediated Potentiation of Morphine Analgesia by St. John’s Wort in Rodents and Humans

Journal of Pharmacological Sciences, 2014
Our purpose was to combine the use of morphine with clinically available inhibitors of protein kinase C (PKC), finally potentiating morphine analgesia in humans.
Nicoletta Galeotti, Mersedeh Farzad, Enrica Bianchi, Carla Ghelardini   +3 more
doaj   +1 more source

Pharmacogenetics of analgesic drugs [PDF]

, 2013
• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R, Cregg, R, Gubbay, A, Russo, G, Sato, H   +4 more
core   +1 more source