Results 121 to 130 of about 24,480 (215)

Things We Do for No Reason™: Withholding opioids among patients with acute pain and opioid use disorder

Journal of Hospital Medicine, Volume 21, Issue 8, Page 928-931, August 2026.
Visual Abstract Abstract Hospitalists care for patients with acute pain who have an opioid use disorder and require pain management. Hospitalists may withhold opioids for acute pain due to a variety of reasons. However, adequate pain management in patients with opioid use disorder, including with opioids, is the standard of care.
Anna‐Maria South, Susan L. Calcaterra, Marlene Martin   +2 more
wiley   +1 more source

Do Injury, Depression, and PTSD Mediate the Relationships Between Latent Profiles of Cumulative Lifetime Violence and Chronic Pain Disability in Men?

Research in Nursing &Health, Volume 49, Issue 4, Page 353-364, August 2026.
ABSTRACT Knowledge of association between violence and chronic pain in men is limited by neglect of violence experiences as perpetrator, disregard of heterogeneity in cumulative lifetime violence severity (CLVS), weak understanding of mediation pathways, and inattention to social determinants of health (SDOH).
Judith Wuest, Sue O'Donnell, Kelly Scott‐Storey, Charlene D. Vincent, Jeannie Malcolm   +4 more
wiley   +1 more source

Kratom (<i>Mitragyna speciosa</i>) as a Phytochemical-Based Natural Product Exhibiting Opioid-like Analgesic Effects with Reduced Tolerance and Dependence Liability via TLR4-Associated Neuroimmune Modulation. [PDF]

Molecules
Prasetya F, Indriyanti N, Mus NM, Bafadal M, Fadilla R, Widiyastuti Y, Chaidir C, Kuncoro H, Fajriah S, Heryanto R, Narsa AC, Fricillia OZ, Sastyarina Y, Fitriani VY, Rouchmana S, Sobah N, Bahar Z, Nisaa NRK, Helmi H, Anshory H.   +19 more
europepmc   +1 more source

Effect of Intraoperative Regional Anesthesia on Postoperative Outcomes in Pediatric Cardiac Surgery—A Systematic Review of Randomized Controlled Trials

Pediatric Anesthesia, Volume 36, Issue 8, Page 899-907, August 2026.
ABSTRACT Objective To conduct a meta‐analysis of postoperative outcomes following the use of regional anesthesia in pediatric cardiac surgery. Data Sources We searched PubMed (MEDLINE), Web of Science, CINAHL, CENTRAL, and Scopus in December 2024 (PROSPERO: CRD420025635423; registered January 2025).
Katariina Hiisivuori, Heli Salmi, Vesa K. Kontinen, Ilari Kuitunen   +3 more
wiley   +1 more source

Structure-Activity Relationships and Ligand-Dependent Arrestin Bias in μ-Opioid Receptor-Mediated ERK Activation. [PDF]

Biomol Ther (Seoul)
Huang L, Wang M, Kundu D, Paudel S, Peng L, Xian X, Jang CG, Kim KM.   +7 more
europepmc   +1 more source

Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso, Ronald Kadada Karyaburo, Jackson K. Mukonzo, Ene I. Ette   +3 more
wiley   +1 more source

Atypical respiration patterns of kratom alkaloids. [PDF]

J Pharmacol Exp Ther
Wells E, Paul B, Ramos-Gonzalez N, Majumdar S.   +3 more
europepmc   +1 more source

Student Perceptions of a Virtual Reality Animation for Teaching Absorption and Bioavailability in Pharmacology: A Mixed Methods Evaluation

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
Four representative screenshots from the 360° VR animation used in the study, showing visualizations of key pharmacological processes related to oral drug absorption and bioavailability. ABSTRACT Medication errors, often arising from insufficient pharmacology knowledge, can have serious consequences, highlighting the importance of effective ...
Jon Andsnes Berg, Trond Trætteberg Serkland, Monika Kvernenes, Johnson Liu, Waltraud Binder, Steve Gallagher, David Reith, Ullamari Pesonen, Dimitra Mitsa, Marit Christine Strandvik, Tiril Egset Mork, Silje Skrede, Paul White   +12 more
wiley   +1 more source

Regional Trends in the Opioid Epidemic Using Safety Signals of Drug Abuse and Dependence: A Disproportionality Analysis Using VigiBase. [PDF]

Drugs Real World Outcomes
Suh B, Oh HS, Shin JY, Kim JH.
europepmc   +1 more source

Targeting the Carotid Body Function With Big‐K+‐Channel Blocker ENA‐001 in Opioid‐Induced Respiratory Depression: A Scoping Review

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Opioids, most intravenous anesthetics and various illicit substances can cause fatal respiratory depression by depressing central respiratory networks. ENA‐001, a ventilatory modulator targeting the carotid bodies, has emerged as a potential countermeasure without impairing analgesia or hypnosis.
Jimmy J. Arevalo, Monique van Velzen, Simone C. Jansen, Maarten van Lemmen, Elise Sarton, Albert Dahan, Erik Olofsen, Joseph F. Cotten, Marieke Niesters, Rutger M. van der Schrier   +9 more
wiley   +1 more source