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Morphine preference in rats previously morphine dependent
Pharmacological Research Communications, 1984Morphine preference and tendency to relapse to morphine tolerance and dependence were studied in rats which were previously made morphine dependent. Tolerance to, and physical dependence on, morphine were initially produced by administration of increasing concentrations of morphine sulphate in 5% sucrose solution for 3 weeks.
S, Dai, S C, Hui, C W, Ogle
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Neuroanatomical Correlates of Morphine Dependence
Science, 1972Naloxone hydrochloride, an opioid antagonist, was applied to several discrete brain regions of morphine-dependent rats to precipitate abstinence. Severe withdrawal signs were elicited after administration in the thalamus but not in neocortical, hippocampal, hypothalamic, or tegmental areas of the brain.
E, Wei, H H, Loh, E L, Way
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Morphine Withdrawal Dramatically Reduces Lymphocytes in Morphine-Dependent Macaques
Journal of Neuroimmune Pharmacology, 2006The immune effects of chronic opiate exposure and/or opiate withdrawal are not well understood. The results of human studies with opiate abusers are variable and may not be able to control for important factors such as subjects' drug histories, health and nutritional status. Nonhuman primate models are necessary to control these important factors.
Michael R, Weed +4 more
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Voluntary morphine ingestion, morphine dependence, and recovery from withdrawal signs
Pharmacology Biochemistry and Behavior, 1975We are reporting on conditions (without forced drinking or premedications) where rats voluntarily drink high quantities of sucrose-morphine solutions in preference to water. The volume ingested is inversely related to the morphine concentration in the liquid. The morphine antagonist, nalorphine, produced a clear set of opiate withdrawal signs in these (
K A, Khavari +3 more
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Conditioned fear exacerbates acute morphine dependence
Pharmacology Biochemistry and Behavior, 1995A variety of physical stressors have been shown to enhance reactivity to opioid drugs. Few studies have examined the effects of nonphysical stressors on opioid drug reactivity. In this regard, it has previously been shown that animals administered morphine in the presence of shock-associated cues demonstrate increases in hypoalgesia relative to ...
G C, Abrahamsen +4 more
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Biological Sciences: Morphine Physical Dependence unaltered by Previous Dependence on Morphine
Nature, 1972AFTER a period of abstinence, narcotic addicts, if untreated with opioids, frequently relapse and resume self-administration of opioid compounds1. Little is known about factors that influence relapse; it has been attributed to the addict's social environment and to his or her psychological need for the drug.
EDDIE WEI, HORACE LOH
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Seasonal variation of morphine physical dependence
Life Sciences, 1982The characteristics of morphine physical dependence in ground squirrels (Citellus lateralis) were examined during each of the four annual seasons. The results showed that this rodent hibernator exhibits a strong and characteristic naloxone-precipitated abstinence syndrome during its non-hibernation state, irrespective of the season.
A L, Beckman +3 more
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Neurosteroids in nicotine and morphine dependence
Psychopharmacology, 2005Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, tolerance, and withdrawal. The neurosteroid allopregnanolone is also able to substitute for drugs with abuse potential and possesses reinforcing properties.The effects of acute treatment with, and discontinuation of, chronic exposure to nicotine or ...
CONCAS, ALESSANDRA +5 more
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Carbamazepine potentiates morphine analgesia on postoperative pain in morphine-dependent rats
European Journal of Pharmacology, 2012Postoperative pain and its control remain one of the most important issues in the field of surgery and health care systems. Morphine is a potent and effective analgesic, but substance abuse patients can manifest cross-tolerance to it, making it difficult to satisfy their analgesic/anesthetic requirements.
Kobra, Naseri +3 more
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Prenatal exposure to morphine or naloxone intensifies morphine dependence at maturity
Pharmacology Biochemistry and Behavior, 1993Pregnant rats were SC injected with physiological saline (control) or 10 mg/kg morphine (morphine group) or 2 mg/kg naloxone (naloxone group) three times daily during the last 5 days of gestation. Three weeks after birth, male young rats of each group were taken and placed in separate cages.
H, Koyuncuoğlu, F, Aricioğlu
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