Results 171 to 180 of about 24,480 (215)

Effect of environmental enrichment on physical and psychological dependence signs and voluntary morphine consumption in morphine-dependent and morphine-withdrawn rats

Behavioural Pharmacology, 2016
This study was designed to examine the effect of environmental enrichment during morphine dependency and withdrawal on the severity of naloxone-precipitated withdrawal signs, anxiety, and depressive-like behaviors and voluntary morphine consumption in morphine-dependent rats.
Arezoo, Hammami-Abrand Abadi, Hossein, Miladi-Gorji, Imanollah, Bigdeli   +2 more
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Effects of Serine on Morphine-Dependent Mice

Pharmacology, 2008
Single doses of serine (250 mg/kg i.p.) failed to elevate central glycine in mice (1 h after injection), or to compensate for losses caused by implantation of morphine base (70 mg/animal), and reduced the jumping response to nalorphine (100 mg/kg i.p.).
N, Filipović, P, Stern, Z, Fuks
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Acute morphine dependence in the hamster

Pharmacology Biochemistry and Behavior, 1991
Two experiments investigated naloxone-precipitated withdrawal following a brief course of morphine administration in hamsters. In Experiment 1, observable withdrawal symptoms (e.g., wet-dog shakes) were elicited by two doses of naloxone (0.4 and 1.0 mg/kg) following four and eight daily injections of morphine (15 mg/kg), a regimen that replicated ...
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Seasonal variation of morphine physical dependence

Life Sciences, 1982
The characteristics of morphine physical dependence in ground squirrels (Citellus lateralis) were examined during each of the four annual seasons. The results showed that this rodent hibernator exhibits a strong and characteristic naloxone-precipitated abstinence syndrome during its non-hibernation state, irrespective of the season.
A L, Beckman, C, Llados-Eckman, T L, Stanton, M W, Adler   +3 more
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Effect of neurohypophyseal hormones on morphine dependence

Psychoneuroendocrinology, 1977
Abstract (1) The development of physical dependence on morphine is facilitated in rats treated with [desglycinamide9-arginine8]-vasopressin (DG-AVP) or with oxytocin. (2) Oxytocin appeared to be more potent than DG-AVP. (3) The essential elements of vasopressin and oxytocin required for facilitating morphine tolerance and physical dependence, are ...
J M, van Ree, D, de Wied
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Cynomolgus monkeys and morphine tolerance and dependence

Drug and Alcohol Dependence, 1985
Cynomolgus monkeys readily developed tolerance to and physical dependence on morphine indistinguishable from that produced by an identical dose regimen in rhesus monkeys.
M D, Aceto, L S, Harris
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Tolerance to and physical dependence on morphine in rats

Psychopharmacologia, 1963
The effects of large doses of morphine in nontolerant and tolerant rats as well as the effects of abruptly withdrawing morphine in rats experimentally addicted to large doses of morphine have been studied on body weight, temperature, metabolic rate, respiratory rate, water consumption and various forms of motor activity and behavior. In confirmation of
W R, MARTIN, A, WIKLER, C G, EADES, F T, PESCOR   +3 more
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Morphine dependence and enzyme activity in the hypothalamus

Biochemical Pharmacology, 1974
Abstract Tolerance to and physical dependence on morphine were produced in rats by the implantation of morphine pellets. When both reached peak levels, the rats were sacrificed and malic dehydrogenase, lactic dehydrogenase and glucose-6-phosphate dehydrogenase were measured by sensitive microchemical methods in eight hypothalamic nuclei and in the ...
C R, Cloninger, P M, Packman, T J, Cicero, R L, Boshans, E, Robins   +4 more
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Dependence to morphine in differentially housed rats

Psychopharmacologia, 1975
Although the effects of differential housing, particularly isolation, on the action of several classes of pharmacological agents have been studied, little attention has been given to this factor in regard to narcotics. The present study involves the effects of long-term social isolation on dependence to morphine produced by pellet implants in rats ...
M W, Adler, C, Bendotti, D, Ghezzi, R, Samanin, L, Valzelli   +4 more
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The Kinetics of Physical Dependence to Morphine in the Rat

Pharmacology, 2008
The time-course of the development and disappearance of physical dependence to morphine was studied in rats using the implantation method of Huidobro and Contreras (8). Groups of 12 rats were challenged with 10 mg/kg of levallorphan tartrate at various times from 3 to 96 h after implantation and the intensity of abstinence gauged by the behavioral ...
L, Grumbach, M, Shelofsky, J E, Boston
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