Results 161 to 170 of about 24,480 (215)
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Rapid induction of dependence to morphine in rats
Neuropharmacology, 1986The rate of development of dependence to morphine was studied in female rats which were given increasing concentrations of morphine sulphate in their drinking fluid (5% sucrose solution). The occurrence of physical dependence was determined by the naloxone-precipitated withdrawal syndrome at various times during the 3-week experimental period.
C W Ogle
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Morphine preference in rats previously morphine dependent
Pharmacological Research Communications, 1984Morphine preference and tendency to relapse to morphine tolerance and dependence were studied in rats which were previously made morphine dependent. Tolerance to, and physical dependence on, morphine were initially produced by administration of increasing concentrations of morphine sulphate in 5% sucrose solution for 3 weeks.
S, Dai, S C, Hui, C W, Ogle
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Neuroanatomical Correlates of Morphine Dependence
Science, 1972Naloxone hydrochloride, an opioid antagonist, was applied to several discrete brain regions of morphine-dependent rats to precipitate abstinence. Severe withdrawal signs were elicited after administration in the thalamus but not in neocortical, hippocampal, hypothalamic, or tegmental areas of the brain.
E, Wei, H H, Loh, E L, Way
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Neurosteroids in nicotine and morphine dependence
Psychopharmacology, 2005Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, tolerance, and withdrawal. The neurosteroid allopregnanolone is also able to substitute for drugs with abuse potential and possesses reinforcing properties.The effects of acute treatment with, and discontinuation of, chronic exposure to nicotine or ...
CONCAS, ALESSANDRA +5 more
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Dependence in the absence of tolerance to morphine
European Journal of Pharmacology, 1984Intravenous morphine depressed the firing of cat dorsal horn neurones to impulses in unmyelinated primary afferents. Electrophoretic administration of naloxone in the substantia gelatinosa between 10 min and 6 h after morphine revealed hyper-responsiveness which was not associated with apparent tolerance to morphine.
S M, Johnson, A W, Duggan
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Role of Morphine Glucuronide Metabolites in Morphine Dependence in the Rat
Pharmacology Biochemistry and Behavior, 1997Concentrations of morphine and its 3- and 6-glucuronide metabolites (M3G and M6G) in plasma, brain, and urine of rats exposed to morphine for either 24 or 48 h were measured using high-performance liquid chromatography. In another group of morphine-treated rats, the intensity of naloxone-precipitated withdrawal behaviours was monitored at 24 and 48 h ...
A, Salem, W, Hope
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Biological Sciences: Morphine Physical Dependence unaltered by Previous Dependence on Morphine
Nature, 1972AFTER a period of abstinence, narcotic addicts, if untreated with opioids, frequently relapse and resume self-administration of opioid compounds1. Little is known about factors that influence relapse; it has been attributed to the addict's social environment and to his or her psychological need for the drug.
EDDIE WEI, HORACE LOH
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Prenatal exposure to morphine or naloxone intensifies morphine dependence at maturity
Pharmacology Biochemistry and Behavior, 1993Pregnant rats were SC injected with physiological saline (control) or 10 mg/kg morphine (morphine group) or 2 mg/kg naloxone (naloxone group) three times daily during the last 5 days of gestation. Three weeks after birth, male young rats of each group were taken and placed in separate cages.
H, Koyuncuoğlu, F, Aricioğlu
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The interaction of morphine with sera from monkeys physically dependent on morphine
Clinical Immunology and Immunopathology, 1975Abstract Serum samples were obtained from 12 monkeys that had received 3 mg/kg aqueous morphine sulfate injections subcutaneously every 6 hr for a mean period of 1.7 yr (9.5 mo to 6 yr). All 12 monkeys were physically dependent on morphine. These sera and appropriate controls were studied for the capacity to bind [ 14 C]morphine by the ammonium ...
B B, Berger +5 more
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Morphine Withdrawal Dramatically Reduces Lymphocytes in Morphine-Dependent Macaques
Journal of Neuroimmune Pharmacology, 2006The immune effects of chronic opiate exposure and/or opiate withdrawal are not well understood. The results of human studies with opiate abusers are variable and may not be able to control for important factors such as subjects' drug histories, health and nutritional status. Nonhuman primate models are necessary to control these important factors.
Michael R, Weed +4 more
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