Results 161 to 170 of about 54,036 (205)
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Locomotor activity in morphine-dependent and post-dependent rats
Pharmacology Biochemistry and Behavior, 1981The effects of morphine and naloxone were compared on the locomotor activity of nondependent, morphine-dependent, and post-dependent rats. Dependence was induced and maintained for 30 weeks by scheduled access to 0.05% morphine solution for 10 min every 6 hr.
L S, Brady, S G, Holtzman
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Role of Morphine Glucuronide Metabolites in Morphine Dependence in the Rat
Pharmacology Biochemistry and Behavior, 1997Concentrations of morphine and its 3- and 6-glucuronide metabolites (M3G and M6G) in plasma, brain, and urine of rats exposed to morphine for either 24 or 48 h were measured using high-performance liquid chromatography. In another group of morphine-treated rats, the intensity of naloxone-precipitated withdrawal behaviours was monitored at 24 and 48 h ...
A, Salem, W, Hope
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Treatment of Morphine-Type Dependence
JAMA: The Journal of the American Medical Association, 1972To the Editor.— As indicated by Dr. Chappel, "Treatment of Morphine-Type Dependence by Withdrawal Methods" is a definitive statement by the AMA. It should be stressed, however, that these guidelines should be interpreted flexibly and should not substitute for thorough clinical evaluation of each individual patient with appropriate application of the ...
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Acute morphine dependence in the hamster
Pharmacology Biochemistry and Behavior, 1991Two experiments investigated naloxone-precipitated withdrawal following a brief course of morphine administration in hamsters. In Experiment 1, observable withdrawal symptoms (e.g., wet-dog shakes) were elicited by two doses of naloxone (0.4 and 1.0 mg/kg) following four and eight daily injections of morphine (15 mg/kg), a regimen that replicated ...
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Effects of Serine on Morphine-Dependent Mice
Pharmacology, 1976Single doses of serine (250 mg/kg i.p.) failed to elevate central glycine in mice (1 h after injection), or to compensate for losses caused by implantation of morphine base (70 mg/animal), and reduced the jumping response to nalorphine (100 mg/kg i.p.).
N, Filipović, P, Stern, Z, Fuks
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Dopamine-induced hypothermia in morphine-dependent rats
Neuropharmacology, 1978Abstract The effect on body temperature of lateral ventricular injection of dopamine was studied in control rats and in rats rendered dependent on morphine by implantation of a subcutaneous pellet. Dopamine induced a significantly greater hypothermie response in animals of the morphine-dependent group when injected 72 hr after pellet implantation ...
P, Lomax, M, Ary, S M, Sorensen
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Morphine-induced thymic hypoplasia is glucocorticoid-dependent
The Journal of Immunology, 1991Abstract Mice administered morphine as a s.c. pellet implant exhibit a marked and sustained thymic hypoplasia as well as suppression of T lymphocyte functions. In the present study, the effects of morphine on thymocyte differentiation were characterized.
Y, Sei +4 more
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Narcotic Receptor Sites in Morphine-dependent Rats
Nature, 1974THE biochemical basis of the development of tolerance for and dependence on narcotic analgesics has been the subject of much speculation and experiment1–6. Theories which try to account for these closely related4,7 phenomena can be grouped into three main classes: (1) the body reacts to narcotic drugs by increasing the rate at which they are destroyed ...
W A, Klee, R A, Streaty
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Vascular adrenergic responses in morphine‐dependent rats
Acta Physiologica Scandinavica, 1990The circulatory effects of morphine abstinence have recently been found to involve decreased renal sympathetic nerve activity and increased mean arterial pressure, induced by vasoconstriction. A direct influence of morphine withdrawal on the peripheral vasculature could possibly contribute to the increased resistance.
H, Gustafsson, M, Delle, H, Nilsson
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Dependence to morphine in differentially housed rats
Psychopharmacologia, 1975Although the effects of differential housing, particularly isolation, on the action of several classes of pharmacological agents have been studied, little attention has been given to this factor in regard to narcotics. The present study involves the effects of long-term social isolation on dependence to morphine produced by pellet implants in rats ...
M W, Adler +4 more
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