Results 241 to 250 of about 10,950 (303)

Design, Syntheses, and Pharmacological Evaluations of Core Ring Expanded Fentanyl Analogues as Potential Counteracting Agents Against Fentanyl Induced Respiratory Depression. [PDF]

J Med Chem
Silte AA, Li E, Kale BS, Neel L, Upadhyay N, Flammia R, Lyu R, St Onge CM, Reda A, Woodard S, Gillespie JC, Kim D, Selley DE, Dewey WL, Pagare PP, Zhang Y.   +15 more
europepmc   +1 more source

Membrane Permeability Drives the Extreme Potency of Fentanyl but not Isotonitazene

Clayton J, Farmer GJ, Glenn J, Mistry SN, Lane JR, Shi L, Stavitskaya L, Canals M, Shen J.   +8 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Comparative lipophilicity of morphine derivatives

Journal of Planar Chromatography – Modern TLC, 2015
Lipophilicity is an important physicochemical characteristic of compounds having potential use in the treatment of humans and animals. Morphine and its semisynthetic derivatives have effects on mu (μ), kappa (κ), and delta (δ) opioid receptors, and their physiological, pharmacological, and therapeutic effects mainly depend on their distribution in the ...
Kalász, Huba, Doležal R,, Tekes, Kornélia, Magyar, Kálmán, Csermely T,, Hosztafi, Sándor   +5 more
openaire   +2 more sources

Luminescence characteristics of morphine derivatives

Journal of the Chemical Society, Perkin Transactions 2, 1977
A detailed study of the fluorescence and phosphorescence characteristics of morphine, diamorphine (heroin), and a number of morphine derivatives has been undertaken. Fluorescence decay times have been determined where appropriate by using a time-correlated single photon counting technique.
Alexander Bowd, James H. Turnbull
openaire   +1 more source

14‐Alkyl‐substituierte Morphin‐Derivate

Chemische Berichte, 1979
AbstractDurch Claisen‐Eschenmoser‐Umlagerung von 1 erhält man 2b, das mit LiAlH4 in das 14‐[2‐(Dimethylamino)ethyl]codeinon‐acetal 2d übergeführt werden kann. Daraus entsteht mit CH3I das 14,17‐Ethanonorcodeinon‐acetal‐methoiodid 4a, das durch Reduktion mit LiBEt3H in sehr guter Ausbeute das 14‐Ethylcodeinon‐acetal 2g liefert, von dem eine Anzahl von ...
Wilhelm Fleischhacker, Bernd Richter
openaire   +1 more source

Synthesis of Morphine Alkaloids and Derivatives

2011
This review summarizes recent developments in the total synthesis of morphine alkaloids and some of the semisynthetic derivatives. The literature is covered for the period of 5 years after the publication of the last review in 2005. The syntheses that appeared in this period are covered in detail and are placed in the context of all syntheses of opiate
Rinner, Uwe, Hudlicky, Tomas
openaire   +3 more sources

Über 14‐(Oxyalkyl)morphin‐Derivate

Chemische Berichte, 1979
Abstract14β‐(Dimethylcarbamoylmethyl)codeinon‐dimethylacetal (1a) sowie dessen Reduktionsprodukt 14β‐(2‐Hydroxyethyl)codeinon‐dimethylacetal (9) erleiden bei der sauren Acetalhydrolyse unerwartete Umlagerungen zu den Lactonen 5 und 6 bzw. den cyclischen Ethern 12 und 13a. Durch Isolierung der Zwischenprodukte 1b, 3, 5 bzw.
Wilhelm Fleischhacker, Bernd Richter
openaire   +1 more source