Results 101 to 110 of about 51,793 (252)

Integrating gepants into clinical practice for the acute treatment of migraine

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To assess the role of small‐molecule calcitonin gene–related peptide receptor antagonists (gepants) in the acute treatment of migraine, particularly in relation to triptan treatments. Background Triptans have established efficacy and are widely prescribed for the acute treatment of migraine.
Richard B. Lipton, David W. Dodick, Linda Davis, Stephanie J. Nahas, Peter J. Goadsby   +4 more
wiley   +1 more source

Effects of glucosamine against morphine-induced antinociceptive tolerance and dependence in mice

Journal of Biomedical Science, 2019
Background The most important limitations of morphine in pain therapy are its tolerance and dependence. In this study, we evaluated the protective effect of glucosamine against morphine-induced tolerance and dependence in mice.
Faezeh Basiri, Abolfazl Rad, Davood Mahdian, Mehdi Molavi, Bahareh Amin   +4 more
doaj   +1 more source

On the possible role of ERK, p38 and CaMKII in the regulation of CGRP expression in morphine-tolerant rats [PDF]

, 2011
Background The neuropeptide, calcitonin gene-related peptide (CGRP) has been proposed to be a regulator of the development of morphine analgesic tolerance and thereby could be a target to reduce the induction of this phenomenon under clinical conditions.
Quirion Remi, Chabot Jean-Guy, Wang Zhiyong   +2 more
core   +1 more source

Partial tarsal arthrodesis with plate fixation for management of traumatic tarsometatarsal injuries in five cats

Journal of Small Animal Practice, EarlyView.
Objectives To describe the aetiology, presentation, complications and outcome in cats with traumatic injuries of the tarsometatarsal joint treated with partial tarsal arthrodesis. Materials and Methods Retrospective series of five client‐owned cats. Medical records were retrieved for cats with traumatic injuries of the tarsometatarsal joint treated ...
R. L. Nixon, D. N. Clements, J. M. Ryan
wiley   +1 more source

Spinal TLR4/P2X7 Receptor-Dependent NLRP3 Inflammasome Activation Contributes to the Development of Tolerance to Morphine-Induced Antinociception

Journal of Inflammation Research, 2020
Haiyan Wang1 ,* Yu Zhang1 ,* Xiaqing Ma,1 Wenying Wang,1 Xiaotao Xu,1 Min Huang,1 Liang Xu,2 Haibo Shi,3 Tifei Yuan,4 Wei Jiang,1 Aizhong Wang,1 Tao Xu1,5 1Department of Anesthesiology, Shanghai Jiao Tong University Affiliated Sixth People’s ...
Wang H, Zhang Y, Ma X, Wang W, Xu X, Huang M, Xu L, Shi H, Yuan T, Jiang W, Wang A, Xu T   +11 more
doaj  

Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner

Experimental and Molecular Medicine, 2018
Pain medicine: why blocking dopamine receptors alleviates morphine tolerance By blocking dopamine receptors located in the spinal cord, a compound found in a traditional Chinese herbal medicine may help mitigate tolerance to morphine, a common problem ...
Wen-Ling Dai, Xin-Tong Liu, Yi-Ni Bao, Bing Yan, Nan Jiang, Bo-Yang Yu, Ji-Hua Liu   +6 more
doaj   +1 more source

Chemical composition of Zhumeria majdae essential oil and its effects on the expression of morphine withdrawal syndrome and tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice [PDF]

Brazilian Journal of Biology
Regarding the proven anticonvulsant effect of Zhumeria majdae essential oil (ZMEO) in previous studies we were prompted to investigate the ZMEO effects on the tolerance to the anticonvulsant effects of morphine and the morphine withdrawal syndrome ...
G. Azimi, J. Asgarpanah
doaj   +2 more sources

Pre‐anaesthetic risk assessment and management of dogs with myxomatous mitral valve disease: a spectrum of care narrative review

Journal of Small Animal Practice, EarlyView.
Myxomatous mitral valve disease, an acquired valvular degeneration, is the most common cardiac disorder in dogs, affecting approximately 10% of dogs in primary care veterinary practice. Dogs with myxomatous mitral valve disease frequently require anaesthesia for routine procedures.
I. Levinzon, L. Köster, E. Vettorato, A. H. Estrada   +3 more
wiley   +1 more source

Inhibition of Histone Deacetylases Attenuates Morphine Tolerance and Restores MOR Expression in the DRG of BCP Rats

Frontiers in Pharmacology, 2018
The easily developed morphine tolerance in bone cancer pain (BCP) significantly hindered its clinical use. Increasing evidence suggests that histone deacetylases (HDACs) regulate analgesic tolerance subsequent to continuous opioid exposure.
Xiao-Tao He, Xiao-Tao He, Kai-Xiang Zhou, Kai-Xiang Zhou, Wen-Jun Zhao, Wen-Jun Zhao, Chen Zhang, Chen Zhang, Jian-Ping Deng, Fa-Ming Chen, Ze-Xu Gu, Yun-Qing Li, Yun-Qing Li, Yu-Lin Dong   +13 more
doaj   +1 more source

Efficacy and Safety of Intra‐Articular Therapies for Temporomandibular Disorders: A Systematic Review and Meta‐Analysis

Oral Diseases, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to evaluate the most effective minimally invasive intra‐articular procedure for reducing pain and improving maximum mouth opening (MMO) in individuals diagnosed with painful articular TMD, specifically TMJ osteoarthritis and/or internal derangement.
Mateus Gaya dos Santos, Wellington Luiz de Oliveira da Rosa, Cristian Sbardelotto, Júlia Silva Gomes de Araújo, Camila da Silva Rodrigues, Noéli Boscato   +5 more
wiley   +1 more source