Results 81 to 90 of about 23,947 (195)

Behavioral Consequences of Delta-Opioid Receptor Activation in the Periaqueductal Gray of Morphine Tolerant Rats

open access: yesNeural Plasticity, 2009
Chronic morphine administration shifts delta-opioid receptors (DORs) from the cytoplasm to the plasma membrane. Given that microinjection of morphine into the PAG produces antinociception, it is hypothesized that the movement of DORs to the membrane will
Michael M. Morgan   +3 more
doaj   +1 more source

Integrative GC–MS, FT‐IR, and Molecular Docking Analysis of Drimycarpus racemosus (Roxb.) Hook.f ex Marchand: In Vivo Analgesic and Antidiabetic Potential

open access: yesFood Science &Nutrition, Volume 14, Issue 8, August 2026.
GC–MS profiling of D. racemosus identified bioactive phytochemicals with promising molecular interactions through docking analysis. The methanolic extract demonstrated significant antinociceptive activity against acetic acid‐ and formalin‐induced pain and exhibited antidiabetic effects in streptozotocin‐induced diabetic Swiss albino mice, supporting ...
Md Sajib Ali   +7 more
wiley   +1 more source

Things We Do for No Reason™: Withholding opioids among patients with acute pain and opioid use disorder

open access: yesJournal of Hospital Medicine, Volume 21, Issue 8, Page 928-931, August 2026.
Visual Abstract Abstract Hospitalists care for patients with acute pain who have an opioid use disorder and require pain management. Hospitalists may withhold opioids for acute pain due to a variety of reasons. However, adequate pain management in patients with opioid use disorder, including with opioids, is the standard of care.
Anna‐Maria South   +2 more
wiley   +1 more source

Targeting the Carotid Body Function With Big‐K+‐Channel Blocker ENA‐001 in Opioid‐Induced Respiratory Depression: A Scoping Review

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Opioids, most intravenous anesthetics and various illicit substances can cause fatal respiratory depression by depressing central respiratory networks. ENA‐001, a ventilatory modulator targeting the carotid bodies, has emerged as a potential countermeasure without impairing analgesia or hypnosis.
Jimmy J. Arevalo   +9 more
wiley   +1 more source

Upregulation of μ-Opioid Receptor in the Rat Spinal Cord Contributes to the α2-Adrenoceptor Agonist Dexmedetomidine-Induced Attenuation of Chronic Morphine Tolerance in Cancer Pain

open access: yesJournal of Pain Research, 2020
Pinyi Zhang,1 Jianlong Bu,2 Xiaohong Wu,1 Lin Deng,1 Meng Chi,1 Chao Ma,3 Xiaoding Shi,1 Guonian Wang3 1Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of China; 2Department of Thoracic Surgery ...
Zhang P   +7 more
doaj  

Patient‐reported outcomes, postoperative pain and pain relief after day‐case surgery (POPPY): short‐term peri‐operative analgesic use

open access: yesAnaesthesia, Volume 81, Issue 8, Page 1057-1067, August 2026.
Summary Introduction An increasing proportion of complex surgical procedures are being performed in the UK as day‐cases, with variable and limited follow up. Discharge prescriptions must provide adequate analgesia, while considering the safety of the patient and public, following best practice guidance and good opioid stewardship.
Anna Ratcliffe   +2083 more
wiley   +1 more source

Suffering, Silence, and the State: Mass Observation's 1994 Assisted Dying Letters and the Enduring Politics of Palliative Care

open access: yesPolitics &Policy, Volume 54, Issue 4, August 2026.
ABSTRACT Assisted dying has returned to UK policy debate amid legislative scrutiny and growing hospice sector instability. This paper brings 1994 Mass Observation data into dialog with contemporary debates to examine how members of the public understood suffering, autonomy, and care at the end of life.
Kathryn McEwan   +2 more
wiley   +1 more source

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

open access: yesChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki   +2 more
wiley   +1 more source

Naringenin may prevent morphine-induced tolerance via inhibiting glycogen synthase kinase-3beta activity in mice [PDF]

open access: yesJournal of Medicinal Plants
Background: Opioids are essential for pain treatment, but their long-term usage results in tolerance. Naringenin, a natural flavonoid found in fruit, inhibits the enzyme that causes opioid tolerance, making it effective in treating neurodegenerative ...
Samira Shirooie   +6 more
doaj  

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