Results 81 to 90 of about 52,092 (254)

Narcotics Addiction and Its Treatment [PDF]

open access: yes, 1957
The ongoing mythologizing of the poet in both criticism and, as recently in a play produced by Wasa teater (Vasa), is reductive, and needs to be confronted.
Winick, Charles
core   +3 more sources

Factors associated with readmission to residential treatment among clients transitioned from detoxification services in Alberta, Canada

open access: yesThe American Journal on Addictions, EarlyView.
Abstract Background and Objectives Readmission to residential treatment increases healthcare costs, strains publicly funded systems, and may not adequately meet clients' needs. This study examined rates and predictors of readmission to residential treatment among clients transitioned from detoxification services.
Abreham Mekonnen
wiley   +1 more source

Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception [PDF]

open access: yes, 2004
Ingestion of placenta or amniotic fluid produces a dramatic enhancement of centrally mediated opioid antinociception in the rat. The present experiments investigated the role of each opioid receptor type (m, d, k) in the antinociception-modulating ...
DiPirro, Jean M., Kristal, Dr. Mark B.
core  

Patient‐reported outcomes, postoperative pain and pain relief after day‐case surgery (POPPY): short‐term peri‐operative analgesic use

open access: yesAnaesthesia, EarlyView.
Summary Introduction An increasing proportion of complex surgical procedures are being performed in the UK as day‐cases, with variable and limited follow up. Discharge prescriptions must provide adequate analgesia, while considering the safety of the patient and public, following best practice guidance and good opioid stewardship.
Anna Ratcliffe   +2083 more
wiley   +1 more source

Sumatriptan effects on morphine-induced antinociceptive tolerance and physical dependence: The role of nitric oxide [PDF]

open access: yes, 2018
Sumatriptan, a 5HT (5-hydroxytryptamine)1B/1D receptor agonist, showed neuroprotection in different studies. The aim of the present study was to investigate the effect of sumatriptan on morphine-induced antinociceptive tolerance and physical dependence.
Akbarian, Reihaneh.   +8 more
core  

BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates [PDF]

open access: yes, 2019
© 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have
Cami-Kobeci, Gerta   +9 more
core   +5 more sources

Methods and Timing of the Assessment of Post‐Operative Pain in Minimally Invasive Hernia Surgery: A Scoping Review Comparing Robotic With Laparoscopic Repair

open access: yesANZ Journal of Surgery, EarlyView.
ABSTRACT Background Minimally invasive techniques, including laparoscopic and robotic‐assisted surgeries, have revolutionized hernia repair by reducing recovery times and postoperative pain (1). Existing studies have explored general outcomes of robotic surgery, including shorter hospital stays and fewer complications (2).
Aisha A. Arayne   +5 more
wiley   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

open access: yesBritish Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander   +5 more
wiley   +1 more source

Endoplasmic Reticulum Stress in Spinal Cord Contributes to the Development of Morphine Tolerance

open access: yesFrontiers in Molecular Neuroscience, 2018
Morphine tolerance remains an intractable problem, which hinders its prolonged use in clinical practice. Endoplasmic reticulum (ER) stress has been proved to play a fundamental role in the pathogenesis of Alzheimer’s disease, diabetes, atherosclerosis ...
Daiqiang Liu   +11 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

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