Results 71 to 80 of about 52,092 (254)

The Emerging Perspective of Morphine Tolerance: MicroRNAs

Pain Research and Management, 2019
Morphine has unfavorable side effects including analgesic tolerance. Morphine tolerance counteracts analgesic efficacy and drives dose escalation. The mechanisms underlying morphine tolerance remain disputed, which has prevented the development of ...
Teng J. Zhang, Yong Qiu, Zhen Hua
doaj   +1 more source

The Circadian Hormone Melatonin Inhibits Morphine-Induced Tolerance and Inflammation via the Activation of Antioxidative Enzymes

Antioxidants, 2020
Opioids are commonly prescribed for clinical pain management; however, dose-escalation, tolerance, dependence, and addiction limit their usability for long-term chronic pain.
Ing-Jung Chen, Chih-Ping Yang, Sheng-Hsiung Lin, Chang-Mei Lai, Chih-Shung Wong   +4 more
doaj   +1 more source

Determinants of Compliance to Enhanced Recovery Protocol After Emergency Laparotomy

World Journal of Surgery, EarlyView.
Enhanced Recovery protocols (ERP) are comprehensive, evidence‐based approaches aimed at accelerating patient recovery and improving surgical results; increasing evidence exists about their adoption in emergency laparotomy. The study aimed to evaluate the compliance to the proposed postoperative pathway and the determinants of late recovery.
Marco Ceresoli, Chiara Fumagalli, Alan Biloslavo, Antonio La Greca, Michele Carlucci, Giovanni Pesenti, Savino Occhionorelli, Pietro Bisagni, Carlo Feo, Dario Tartaglia, Dario Parini, Matteo Runfola, Riccardo Somigli, Diego Visconti, Diego Mariani, Diletta Cassini, Andrea Mingoli, Marco Braga, On behalf of the Study Collaborative Group   +18 more
wiley   +1 more source

Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation

Journal of Neuroinflammation, 2017
Background Long-term use of morphine induces analgesic tolerance, which limits its clinical efficacy. Evidence indicated morphine-evoked neuroinflammation mediated by toll-like receptor 4 (TLR4) - NOD-like receptor protein 3 (NLRP3) inflammasome was ...
Jie Qu, Xue-You Tao, Peng Teng, Yan Zhang, Ci-Liang Guo, Liang Hu, Yan-Ning Qian, Chun-Yi Jiang, Wen-Tao Liu   +8 more
doaj   +1 more source

High‐Altitude Hypoxemia in Adults With Sickle Cell Disease (SCD)

American Journal of Hematology, EarlyView.
Mofiyin A. Obadina, Sherri Morris, Tara Alin, Barbara LeVarge, Jane A. Little   +4 more
wiley   +1 more source

Physicians' hybridisation with accounting in public hospitals

Accounting &Finance, EarlyView.
Abstract Accounting information has become an integral part of management tools in public hospitals. Following COVID‐19, the crisis in the supply chain and the war in Ukraine severely impacted the financing of public hospitals. In response to this multi‐crisis environment, physicians have increased their awareness on an efficient use of scarce ...
Susana Gago‐Rodríguez, Amélia Ferreira‐da‐Silva, Belen Fernandez‐Feijoo   +2 more
wiley   +1 more source

BTP2, a store-operated calcium channel inhibitor, attenuates morphine antinociceptive tolerance in rats

Frontiers in Neuroscience
IntroductionMorphine antinociceptive tolerance remains a critical problem in the clinical management of pain. Spinal cord glial cell activation and neuroinflammation appear to play a crucial role in the development and maintenance of this tolerance. BTP2,
Weibo Xiao, Feng Xiao, Yingying Zhang, Lei Zeng   +3 more
doaj   +1 more source

Identification of lncRNA expression profiles and ceRNA analysis in the spinal cord of morphine-tolerant rats

Molecular Brain, 2018
Morphine tolerance is a challenging clinical problem that limits the use of morphine in pain treatment, but the mechanisms of morphine tolerance remain unclear.
Jiali Shao, Jian Wang, Jiangju Huang, Chang Liu, Yundan Pan, Qulian Guo, Wangyuan Zou   +6 more
doaj   +1 more source

Enhancement of tolerance development to morphine in rats prenatally exposed to morphine, methadone, and buprenorphine [PDF]

, 2010
[[abstract]]BACKGROUND: Abuse of addictive substances is a serious problem that has a significant impact on areas such as health, the economy, and public safety.
Yao-Chang Chiang, Tsai-Wei Hung, Cynthia Wei-Sheng Lee, Jia-Ying Yan, Ing-Kang Ho   +4 more
core   +1 more source

Rare but relevant: Ibogaine and cardiovascular complications—prolonged QT interval and ventricular arrhythmias

Addiction, EarlyView.
Abstract Revived interest in psychedelic‐assisted therapies has also renewed focus on ibogaine, a psychoactive alkaloid, for its notable anti‐addictive potential. Evidence from observational, open‐label, and limited randomized placebo‐controlled trials indicates that ibogaine and its metabolite noribogaine reduce craving and withdrawal symptoms in ...
Tibor Markus Brunt
wiley   +1 more source