Results 71 to 80 of about 685,770 (240)

Hemodynamic Effects of Prolonged Apneic Oxygenation in Laryngologic Surgery: A Randomized Controlled Pilot Trial

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Limited data exist on cardiocirculatory responses associated with extended periods of apnea during administration of high‐flow nasal oxygen for laryngologic surgery (apneic oxygenation with HFNO, AO‐HFNO). The possibility of hemodynamic compromise in the settings of acute hypercapnia, respiratory acidosis, hyperoxia, and IV ...
Vladimir Nekhendzy, Hendrikus J. Lemmens, Amit R. Saxena, Brita M. Mittal, Edward J. Damrose, C. Kwang Sung, Raffick Bowen   +6 more
wiley   +1 more source

The Regulatory Mechanisms and Therapeutic Potential of MicroRNAs: From Chronic Pain to Morphine Tolerance

Frontiers in Molecular Neuroscience, 2018
Chronic pain, including cancer-related pain, is a pain condition often caused by inflammation or dysfunctional nerves. Chronic pain treatment poses a significant health care challenge, where opioids especially morphine are widely used and patients often ...
Zhao Dai, Haichen Chu, Jiahai Ma, Ying Yan, Xueying Zhang, Yongxin Liang   +5 more
doaj   +1 more source

Chronic pain treatment experiences and barriers among opioid agonist treatment participants who inject drugs: A qualitative study

Addiction, EarlyView.
Abstract Background and aim Co‐occurring chronic pain affects nearly half of people receiving opioid use disorder (OUD) treatment. Although this pain is often severe, it is usually inadequately managed. Stigma and clinical complexity associated with OUD are thought to further restrict access to pain care.
Jie Yang, Shelley Walker, Amy G. McNeilage, Peter Higgs, Louisa Picco, Paul Dietze, Suzanne Nielsen   +6 more
wiley   +1 more source

Opioid Prescribing Changes in Advanced Cancer Before and After Withdrawal of Hydromorphone Slow‐Release Tablets

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Hydromorphone slow‐release tablet withdrawal from the Australian market altered opioid prescribing patterns in advanced cancer pain. Methadone use increased by nearly 50% and median doses doubled. There may be a need to tailor clinician training on safe and effective use of methadone and other opioids as appropriate. ABSTRACT Aim Ongoing disruptions to
Aaron K. Wong, Helen McManus, Sara Vogrin, Youseph Dib, Monnette Samo, Jonathan La, Brian Le, Jennifer Philip   +7 more
wiley   +1 more source

Updated EAACI Statement on Drug Hypersensitivity Skin Testing: Methodology and Non‐Irritative Concentrations

Allergy, EarlyView.
ABSTRACT These updated EAACI guidelines aim to standardize skin testing methodologies for both immediate and non‐immediate drug hypersensitivity reactions. For immediate reactions, the optimal testing window is 4–6 weeks post‐reaction; whereas beyond 6 months, false‐negative results increase.
Annick Barbaud, Lene Heise Garvey, Elizabeth Phillips, Michael Ardern‐Jones, Sevim Bavbek, Patrizia Bonadonna, Jean‐Christoph Caubet, Ana‐Maria Copaescu, Valentina Gueli, Jose Julio Laguna, Ricardo Madrigal‐Burgaleta, Francesca Mori, Vito Sabato, Maria J Torres, Knut Brockow   +14 more
wiley   +1 more source

Tolerance to the Antinociceptive Effects of Chronic Morphine Requires C-Jun N-Terminal Kinase

Molecular Pain, 2015
Background Morphine and fentanyl are opioid analgesics in wide clinical use that act through the μ-opioid receptor (MOR). However, one limitation of their long-term effectiveness is the development of tolerance. Receptor desensitization has been proposed
David J. Marcus, Michael Zee, Alex Hughes, Matthew B. Yuill, Andrea G. Hohmann, Ken Mackie, Josée Guindon, Daniel J. Morgan   +7 more
doaj   +1 more source

The effects of adding ketamine to morphine in patient-controlled intravenous analgesia after orthopedic surgeries [PDF]

Aim and Background: A routine method to control post-operative pain is patient-controlled intravenous analgesia (PCIA) using opioids. Regarding complications of opioids, it seems necessary to reduce their dosage and to improve the quality of analgesia ...
ایمانی, فرناد, محمدیان اردی, علی, اخوان اکبری, قدرت   +2 more
core  

PROSPECT guideline for total hip arthroplasty: updated systematic review and procedure‐specific postoperative pain management recommendations

Anaesthesia, EarlyView.
Summary Introduction The Procedure Specific Postoperative Pain Management (PROSPECT) collaboration develops evidence‐based recommendations integrating analgesic efficacy, safety and functional recovery. Since publication of the 2021 PROSPECT guidelines for total hip arthroplasty, new evidence, particularly on motor‐sparing regional techniques, has ...
Michele Carella, Dario Bugada, Marc Van de Velde, Helene Beloeil, Eric Albrecht, Patricia Lavandhomme, Johan Raeder, Girish P. Joshi, on behalf of the PROSPECT Working Group of the European Society of Regional Anesthesia and Pain Therapy   +8 more
wiley   +1 more source

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Reversing Morphine Induced Tolerance: Insights Into Cetirizine and Green Tea Extract Efficacy

Current Therapeutic Research
Background: The treatment of chronic pain presents a considerable difficulty, particularly due to opioid dependence, which is marked by tolerance and withdrawal symptoms.
Tahereh Eteraf-Oskouei, Phd, Adel Mahmoudi Gharehbaba, Phd, Solmaz Asnaashari, Phd, Zahra Fazli, Phd, Bohloul Habibi Asl, Phd   +4 more
doaj   +1 more source