Results 61 to 70 of about 23,947 (195)

Reversing Morphine Induced Tolerance: Insights Into Cetirizine and Green Tea Extract Efficacy

Current Therapeutic Research
Background: The treatment of chronic pain presents a considerable difficulty, particularly due to opioid dependence, which is marked by tolerance and withdrawal symptoms.
Tahereh Eteraf-Oskouei, Phd, Adel Mahmoudi Gharehbaba, Phd, Solmaz Asnaashari, Phd, Zahra Fazli, Phd, Bohloul Habibi Asl, Phd   +4 more
doaj   +1 more source

Tolerance to the Antinociceptive Effects of Chronic Morphine Requires C-Jun N-Terminal Kinase

Molecular Pain, 2015
Background Morphine and fentanyl are opioid analgesics in wide clinical use that act through the μ-opioid receptor (MOR). However, one limitation of their long-term effectiveness is the development of tolerance. Receptor desensitization has been proposed
David J. Marcus, Michael Zee, Alex Hughes, Matthew B. Yuill, Andrea G. Hohmann, Ken Mackie, Josée Guindon, Daniel J. Morgan   +7 more
doaj   +1 more source

Management of Non‐Plaque‐Induced Gingival Conditions: A Systematic Review—Part 2: Inflammatory and Immune Conditions; Neoplasms; and Gingival Pigmentation

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aims This systematic review assesses current evidence on the management of non‐plaque (dental biofilm)‐induced gingival diseases and conditions (NPIGDs), including (i) inflammatory and immune conditions, (ii) neoplasms and (iii) gingival pigmentations.
Maria Clotilde Carra, Cecile Wasielewski, Bruno Špiljak, Maja Sabalić‐Schoener, Sebastien Jungo, Ivan Alajbeg   +5 more
wiley   +1 more source

Guideline for Medication Management of Distressing Symptoms in Older Patients Receiving End‐of‐Life Palliative Care

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Older patients receiving end‐of‐life palliative care often present with multiple geriatric syndromes, frailty, and comorbid symptom burden, resulting in a high risk of medication‐related harm. This guideline focuses on pharmacological management of distressing symptoms in older patients receiving end‐of‐life or hospice‐oriented palliative care,
Daiping Li, Yanwu Yang, Yan Zhang, Jirong Yue, Birong Dong, Meiling Ge, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University   +7 more
wiley   +1 more source

-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s):Dependence and tolerance to opioid analgesics are major problems limiting their clinical application. a-Terpineol is a monoterpenoid alcohol with neuroprotective effects which is found in several medicinal plants such as Myrtus communis ...
Siavash Parvardeh, Mahsa Moghimi, Pegah Eslami, Alireza Masoudi   +3 more
doaj  

Pre‐anaesthetic risk assessment and management of dogs with myxomatous mitral valve disease: a spectrum of care narrative review

Journal of Small Animal Practice, EarlyView.
Myxomatous mitral valve disease, an acquired valvular degeneration, is the most common cardiac disorder in dogs, affecting approximately 10% of dogs in primary care veterinary practice. Dogs with myxomatous mitral valve disease frequently require anaesthesia for routine procedures.
I. Levinzon, L. Köster, E. Vettorato, A. H. Estrada   +3 more
wiley   +1 more source

Yokukansan (Kampo medicinal formula) prevents the development of morphine tolerance by inhibiting the secretion of orexin A

Integrative Medicine Research, 2018
Background: Yokukansan (YKS), a traditional herbal (Kampo) medicine consisting of seven herbs, is effective in the treatment of pain disorders, such as headache, postherpetic neuralgia, fibromyalgia, and trigeminal neuralgia, and we have previously shown
Ayami Katayama, Yasuaki Kanada, Mana Tsukada, Yuko Akanuma, Haruka Takemura, Takahiro Ono, Hiroki Suga, Hitoshi Mera, Tadashi Hisamitsu, Masataka Sunagawa   +9 more
doaj   +1 more source

Characterization of the Pharmacokinetics and Physiological Effects of Tapentadol in Horses

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Tapentadol is a dual mechanism analgesic utilizing both μ‐opioid receptor (MOR) agonism and norepinephrine reuptake inhibition (NRI). This study evaluated the pharmacokinetics and pharmacodynamics of tapentadol as a potential analgesic with the goal of treating pain in horses.
Annabella D. Lynch, Khursheed R. Mama, Dan S. McKemie, Phillip H. Kass, Heather K. Knych   +4 more
wiley   +1 more source

Chemical composition of Zhumeria majdae essential oil and its effects on the expression of morphine withdrawal syndrome and tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice [PDF]

Brazilian Journal of Biology
Regarding the proven anticonvulsant effect of Zhumeria majdae essential oil (ZMEO) in previous studies we were prompted to investigate the ZMEO effects on the tolerance to the anticonvulsant effects of morphine and the morphine withdrawal syndrome ...
G. Azimi, J. Asgarpanah
doaj   +2 more sources

Efficacy and Safety of Intra‐Articular Therapies for Temporomandibular Disorders: A Systematic Review and Meta‐Analysis

Oral Diseases, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to evaluate the most effective minimally invasive intra‐articular procedure for reducing pain and improving maximum mouth opening (MMO) in individuals diagnosed with painful articular TMD, specifically TMJ osteoarthritis and/or internal derangement.
Mateus Gaya dos Santos, Wellington Luiz de Oliveira da Rosa, Cristian Sbardelotto, Júlia Silva Gomes de Araújo, Camila da Silva Rodrigues, Noéli Boscato   +5 more
wiley   +1 more source