Results 61 to 70 of about 685,770 (240)

Analgesic use, safety and pharmacokinetics of acetaminophen in equids: A structured scoping review

Equine Veterinary Journal, EarlyView.
Abstract Background Despite its frequent use in equine clinical practice, scientific data on the use of acetaminophen in horses remain limited. Objective To map and critically appraise the available evidence on the analgesic use, safety and pharmacokinetics of acetaminophen in horses. Study Design Structured scoping review.
Francisco Medina‐Bautista, Juan Manuel Serrano‐Rodríguez, María del Mar Granados   +2 more
wiley   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Effects of Quercetin and ACTH on Morphine-Induced Tolerance and Dependence in Mice: Attenuation of morphine tolerance by quercetin

, 2006
The goal of this study was to evaluate the effects of quercetin and ACTH injection on prevention of development of morphine tolerance and dependence in mice. In this study different groups of mice received morphine (40 mg/kg, i.p.) plus quercetin (5, 10,
Habibi Asl, Bohlul, Assady, Malahat, Delazar, Abbas   +2 more
core   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Zimelidine attenuates the development of tolerance to morphine-induced antinociception

, 2012
Objectives: The aim of this study was to investigate effect of zimelidine (a serotonin reuptake inhibitor) on morphine-induced tolerance in rats. Materials and Methods: Male Wistar albino rats weighing 160-180 g were used in these experiments (n=72). A 3-
Durmus, Nedim, Bagcivan, Ihsan, Ozdemir, Ercan, Altun, Ahmet, Gursoy, Sinan   +4 more
core   +1 more source

Safety and Efficacy of the Versius Surgical System in Transoral Robotic Surgery: A Prospective Study

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate the safety and feasibility of the Versius surgical robotic system for transoral robotic surgery in benign and malignant head and neck indications. Study Design Open‐label, prospective, single‐arm, phase II clinical trial. Setting Liverpool Head and Neck Centre, United Kingdom. Methods Between December 2023 and March 2025,
Jason C. Fleming, Katharine Davies, Christopher Loh, Mark Wilkie, Xander Lawson, Saul Truckle, James Constable, Jennifer Gwinnutt, Jennifer Rodrigues, Paul Banks, Zoe Mellor, Terry M. Jones   +11 more
wiley   +1 more source

Endoplasmic Reticulum Stress in Spinal Cord Contributes to the Development of Morphine Tolerance

Frontiers in Molecular Neuroscience, 2018
Morphine tolerance remains an intractable problem, which hinders its prolonged use in clinical practice. Endoplasmic reticulum (ER) stress has been proved to play a fundamental role in the pathogenesis of Alzheimer’s disease, diabetes, atherosclerosis ...
Daiqiang Liu, Yaqun Zhou, Yawen Peng, Peng Su, Zheng Li, Qiaoqiao Xu, Ye Tu, Xuebi Tian, Hui Yang, Zhen Wu, Wei Mei, Feng Gao   +11 more
doaj   +1 more source

Role of Gut Microbiota in Morphine-induced Analgesic Tolerance [PDF]

, 2019
University of Minnesota Ph.D. dissertation. August 2019. Major: Pharmacology. Advisor: Sabita Roy. 1 computer file (PDF); xii, 143 pages.Prolonged exposure to opioids results in analgesic tolerance, drug overdose, and death.
Zhang, Li
core  

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source