Drug addiction as a physical disease:The role of physical dependence and other chronic drug-induced neurophysiological changes in compulsive drug self-administration [PDF]
, 1998 Physical-dependence-based theories of addiction regard compulsive drug taking as the behavioral manifestation of a desperate need to relieve aversive autonomic withdrawal symptoms.
Lyvers, Michael
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DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion. [PDF]
, 2017 INTRODUCTION:The perioperative pain experience shows great interindividual variability and is difficult to predict. The mu-1 opioid receptor gene (OPRM1) is known to play an important role in opioid-pain pathways.
Chidambaran, Vidya +8 more
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Redox BiologyMorphine, a typical opiate, is widely used for controlling pain but can lead to various side effects with long-term use, including addiction, analgesic tolerance, and hyperalgesia.
Ling-Yan Su +10 more
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On the possible role of ERK, p38 and CaMKII in the regulation of CGRP expression in morphine-tolerant rats [PDF]
, 2011 Background The neuropeptide, calcitonin gene-related peptide (CGRP) has been proposed to be a regulator of the development of morphine analgesic tolerance and thereby could be a target to reduce the induction of this phenomenon under clinical conditions.
Quirion Remi +2 more
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Tolerance to Morphine Analgesia: Influence of Pain and Method of Morphine Delivery
Pain Research and Management, 2000 Whether some kinds of pain can modify the development of tolerance to morphine analgesia is a controversial issue. Clinically, the development of tolerance is often difficult to establish because many factors can contribute to a decline in analgesic ...
Scott A Chen, Anthony L Vaccarino
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miR-873a-5p Targets A20 to Facilitate Morphine Tolerance in Mice
Frontiers in Neuroscience, 2019 Long-term morphine administration leads to tolerance and a gradual reduction in analgesic potency. Noncoding microRNAs (miRNAs) modulate gene expression in a posttranscriptional manner, and their dysregulation causes various diseases.
Jiangju Huang +9 more
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Role of Glial Cells in Morphine Tolerance and Treatment
Zhongliu Fangzhi Yanjiu, 2019 Morphine is the most common potent analgesic for the treatment of severe pain. However, chronic administration of morphine would lead to the development of analgesic tolerance, and tolerance seriously inhibits the application of morphine in clinical ...
YAN Wenjia, SUN Li
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Opiate Drug Seeking and Addiction: The Influence of Sucrose Consumption on the Acquisition and Expression of Morphine-induced Conditioned Place Preferences (CPP) [PDF]
, 2019 Sucrose intake may lead to changes in brain and behavior similar to the effects of abused drugs. For example, sucrose may agonize endogenous opiate systems and modulate opiate-seeking behavior.
Bakner, Lee +3 more
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Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat [PDF]
, 2015 Background and Purpose The effects of ketamine in attenuating morphine tolerance have been suggested to result from a pharmacodynamic interaction. We studied whether ketamine might increase brain morphine concentrations in acute coadministration, in ...
Coffman BL +6 more
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Getting hooked: Morphine tolerance [PDF]
The Biochemist, 2007 Morphine acts on the Gi/Go-coupled -opioid receptor (MOR). The cellular mechanisms underlying tolerance to morphine are poorly understood but research has focused on desensitization and trafficking of MORs. Surprisingly, different agonists at the MOR elicit desensitization by entirely different cellular mechanisms.
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