Results 31 to 40 of about 685,770 (240)
Tolerance to Morphine Analgesia: Influence of Pain and Method of Morphine Delivery
Pain Research and Management, 2000 Whether some kinds of pain can modify the development of tolerance to morphine analgesia is a controversial issue. Clinically, the development of tolerance is often difficult to establish because many factors can contribute to a decline in analgesic ...
Scott A Chen, Anthony L Vaccarino
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miR-873a-5p Targets A20 to Facilitate Morphine Tolerance in Mice
Frontiers in Neuroscience, 2019 Long-term morphine administration leads to tolerance and a gradual reduction in analgesic potency. Noncoding microRNAs (miRNAs) modulate gene expression in a posttranscriptional manner, and their dysregulation causes various diseases.
Jiangju Huang +9 more
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Advanced Science, EarlyView.A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung +15 more
wiley +1 more source
Role of Glial Cells in Morphine Tolerance and Treatment
Zhongliu Fangzhi Yanjiu, 2019 Morphine is the most common potent analgesic for the treatment of severe pain. However, chronic administration of morphine would lead to the development of analgesic tolerance, and tolerance seriously inhibits the application of morphine in clinical ...
YAN Wenjia, SUN Li
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Advanced Science, EarlyView.Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi +8 more
wiley +1 more source
Advanced Science, EarlyView.Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng +7 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden +3 more
wiley +1 more source
Profiling the Effects of Repetitive Morphine Administration on Motor Behavior in Rats
Molecules, 2021 Efficient repetitive clinical use of morphine is limited by its numerous side effects, whereas analgesic tolerance necessitates subsequent increases in morphine dose to achieve adequate levels of analgesia.
Alok K. Paul +2 more
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Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence
, 2008 SummaryOpioid drugs, such as morphine, are among the most effective analgesics available. However, their utility for the treatment of chronic pain is limited by side effects including tolerance and dependence.
Kharazia, Viktor +11 more
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EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS
, 2023 Absract: The latest research have demonstrated that inflammation, oxidative stress and apoptosis plays a majör role in morphine analgesia and tolerance development.
Çiltaş, Arzuhan Çetindağ +2 more
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