Results 31 to 40 of about 52,092 (254)

In Vivo Imaging of Neuronal Activity Shifts in the Somatosensory Cortex After Morphine Tolerance in Mice. [PDF]

Addict Biol
Morphine tolerance drives reorganization of neuronal activity in the somatosensory cortex. ABSTRACT Morphine is widely used to treat severe pain, but its analgesic effect diminishes with repeated use due to the development of tolerance. Reversing this tolerance remains a clinical challenge, as its underlying mechanisms are complex and not fully ...
Zhang G, Meng W, Xu LJ, Mou B, Xiang Z, Ruan X, Liu YU, Shu H.   +7 more
europepmc   +2 more sources

Unconditioned and learned morphine tolerance influence hippocampal-dependent short-term memory and the subjacent expression of GABA-A receptor alpha subunits.

PLoS ONE, 2021
Backgroundɣ-aminobutyric acid (GABA) facilitator valproic acid may be able to curb memory disruption induced by morphine exposure.ObjectiveThe effects of the GABA facilitator valproic acid on the behavioral tolerance induced by morphine were investigated.
Ghazaleh Ghamkharinejad, Seyed Hossein Marashi, Forough Foolad, Mohammad Javan, Yaghoub Fathollahi   +4 more
doaj   +1 more source

The challenge of perioperative pain management in opioid-tolerant patients [PDF]

, 2017
The increasing number of opioid users among chronic pain patients, and opioid abusers among the general population, makes perioperative pain management challenging for health care professionals.
Bifulco, F, Coluzzi, Flaminia, Corcione, A., Cuomo, A, Dauri, M, Leonardi, C, Melotti, Rm, Natoli, S, Romualdi, P, Savoia, G   +9 more
core   +2 more sources

Src Kinase Inhibition Attenuates Morphine Tolerance without Affecting Reinforcement or Psychomotor Stimulation [PDF]

, 2017
BACKGROUND: Prolonged opioid administration leads to tolerance characterized by reduced analgesic potency. Pain management is additionally compromised by the hedonic effects of opioids, the cause of their misuse.
Baptista-Hon, Daniel T., Bull, Fiona A., Hales, Tim G., Sneddon, Claire, Walwyn, Wendy, Wright, Lisa   +5 more
core   +3 more sources

The effect of metformin on morphine analgesic tolerance and dependence in rats

Research in Pharmaceutical Sciences, 2018
Opiate tolerance and dependence is a worldwide public health problem and gives a significant burden to society. The aim of this study was to evaluate the effects of metformin (MET) on development and expression of morphine tolerance and dependence in ...
Iman Fatemi, Morteza Amirteimoury, Ali Shamsizadeh, Ayat Kaeidi   +3 more
doaj   +1 more source

Interactions of (2S,6S;2R,6R)-Hydroxynorketamine, a Secondary Metabolite of (R,S)-Ketamine, with Morphine [PDF]

, 2018
Ketamine and its primary metabolite norketamine attenuate morphine tolerance by antagonising N-methyl-d-aspartate (NMDA) receptors. Ketamine is extensively metabolized to several other metabolites.
Adams, Bell, Bell, Cao, Chen, Coffman, Coffman, Curtis, Desta, Ebert, Gostin, Hardy, Holtman, Holtman, Jiang, Kilkenny, King, Leung, Lilius, Lilius, Loram, Loram, Maeng, McGrath, Mendez, Moaddel, Moaddel, Paul, Portmann, Pritchard, Qi, Roeckel, Singh, Singh, Trujillo, Trujillo, Uchaipichat, White, Woolf, Xu, Zanos, Zarate, Zhang, Zheng, Zimmermann   +44 more
core   +1 more source

Phosphoproteomics and bioinformatics analyses of spinal cord proteins in rats with morphine tolerance. [PDF]

PLoS ONE, 2014
Morphine is the most effective pain-relieving drug, but it can cause unwanted side effects. Direct neuraxial administration of morphine to spinal cord not only can provide effective, reliable pain relief but also can prevent the development of ...
Wen-Jinn Liaw, Cheng-Ming Tsao, Go-Shine Huang, Chin-Chen Wu, Shung-Tai Ho, Jhi-Joung Wang, Yuan-Xiang Tao, Hao-Ai Shui   +7 more
doaj   +1 more source

Role of D1/D2 dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in rats

Biomolecules & Biomedicine, 2013
While opioid receptors have been implicated in the development of tolerance, the subsequent mechanisms involved in these phenomena have not been completely understood.
Ercan Ozdemir, Ihsan Bagcivan, Sinan Gursoy   +2 more
doaj   +1 more source

Post-mortem toxicology: A pilot study to evaluate the use of a Bayesian network to assess the likelihood of fatality [PDF]

, 2015
The challenge of interpreting post-mortem drug concentrations is well documented and relies on appropriate sample collection, knowledge of case circumstances as well as reference to published tables of data, whilst taking into account the known issues of
Bolton, Jennifer, Carlin, Michelle, Langford, Alan, Palmer, Ray   +3 more
core   +1 more source

The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users [PDF]

, 2016
Aims: Activation of PPARγ by pioglitazone (PIO) has shown some efficacy in attenuating addictive-like responses in laboratory animals. The ability of PIO to alter the effects of opioids in humans has not been characterized in a controlled laboratory ...
Alonzo, Banks, Begelow, Beitner-Johnson, Berger, Bhargava, Bland, Bush, Bussiere, Carr, Chang, Cone, Cooper, de Guglielmo, de Guglielmo, Dhalla, Eisenstein, Eisenstein, Eisenstein, Eng, Ferguson, Fraser, Gagnon, Garrido, Gelinas, Gillies, Hopkins, Hutchinson, Hutchinson, Hutchinson, Jeanne M. Manubay, Jermaine D. Jones, Johnston, Katz, Kielian, Kreutzberg, Ledeboer, Levine, Maria A. Sullivan, Marie-Claire, Martin, Mellon, Moreno, Nakajima, Narita, Pacifici, Pelvig, Roberto Ciccocioppo, Sandra D. Comer, Sarruf, Shanthi Mogali, Song, SPSS, Stoll, Stopponi, Stopponi, Strain, Sweitzer, Tawfik, Tontonoz, Verena E. Metz, Verkhratsky, Walker, Walker, Walsh, Walsh, Watkins, Watkins, Wightman, Woods, Wybran, Zacny, Zacny, Zacny, Zhang   +74 more
core   +1 more source