Results 21 to 30 of about 685,770 (240)

Modulation of Morphine Analgesia, Antinociceptive Tolerance, and Mu-Opioid Receptor Binding by the Cannabinoid CB2 Receptor Agonist O-1966

Frontiers in Pharmacology, 2022
Acutely, non-selective cannabinoid (CB) agonists have been shown to increase morphine antinociceptive effects, and we and others have also demonstrated that non-selective CB agonists attenuate morphine antinociceptive tolerance. Activation of cannabinoid
Zachary W. Reichenbach, Zachary W. Reichenbach, Kelly DiMattio, Suren Rajakaruna, David Ambrose, William D. Cornwell, Ronald J. Tallarida, Thomas Rogers, Lee-Yuan Liu-Chen, Ronald F. Tuma, Sara Jane Ward   +10 more
doaj   +1 more source

Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]

, 2013
Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Nunez, Cristina, Edina Zelei, M Victoria Milanés, Polyák, Ágnes, Zelei, Edina, Agnes Polyák, Krisztina J Kovács, Kovács, Krisztina J., Cristina Núnez, Milanes, Victoria M., Pintér-Kübler, Bernadett, Ferenczi, Szilamér, Bernadett Pintér-Kübler, Szilamér Ferenczi   +13 more
core   +3 more sources

Functionally selective signaling for morphine and fentanyl antinociception and tolerance mediated by the rat periaqueductal gray. [PDF]

PLoS ONE, 2014
Functionally selective signaling appears to contribute to the variability in mechanisms that underlie tolerance to the antinociceptive effects of opioids.
Michael M Morgan, Rachel A Reid, Kimber A Saville   +2 more
doaj   +1 more source

Morphine-3-glucuronide causes antinociceptive cross-tolerance to morphine and increases spinal substance P expression [PDF]

, 2020
Morphine-3-glucuronide (M3G), the main metabolite of morphine, has been implicated in the development of tolerance and of opioid-induced hyperalgesia, both limiting the analgesic use of morphine.
Viisanen, Hanna, Sidorova, Yulia A., Rauhala, Pekka V., Suleymanova, Ilida, Lilius, Tuomas O., Kalso, Eija A., Ahlstrom, Fredrik H. G., Rauhala, Pekka, V, Jokinen, Viljami, Blomqvist, Kim, Blomqvist, Kim J.   +10 more
core   +1 more source

Unconditioned and learned morphine tolerance influence hippocampal-dependent short-term memory and the subjacent expression of GABA-A receptor alpha subunits.

PLoS ONE, 2021
Backgroundɣ-aminobutyric acid (GABA) facilitator valproic acid may be able to curb memory disruption induced by morphine exposure.ObjectiveThe effects of the GABA facilitator valproic acid on the behavioral tolerance induced by morphine were investigated.
Ghazaleh Ghamkharinejad, Seyed Hossein Marashi, Forough Foolad, Mohammad Javan, Yaghoub Fathollahi   +4 more
doaj   +1 more source

Role of Acetaldehyde in Ethanol Reversal of Tolerance to Morphine-Induced Respiratory Depression in Mice [PDF]

, 2022
Background: Opioid users regularly consume other drugs such as alcohol (ethanol). Acute administration of ethanol rapidly reverses tolerance to morphine-induced respiratory depression. However, recent research has suggested that the primary metabolite of
Henderson, Graeme, Hill, Rob, Conibear, Alexandra, Dewey, William, Kelly, Eamonn, William Dewey, Graeme Henderson, Rob Hill, Alexandra Conibear, Eamonn Kelly   +9 more
core   +1 more source

The effect of metformin on morphine analgesic tolerance and dependence in rats

Research in Pharmaceutical Sciences, 2018
Opiate tolerance and dependence is a worldwide public health problem and gives a significant burden to society. The aim of this study was to evaluate the effects of metformin (MET) on development and expression of morphine tolerance and dependence in ...
Iman Fatemi, Morteza Amirteimoury, Ali Shamsizadeh, Ayat Kaeidi   +3 more
doaj   +1 more source

Valproic acid inhibits analgesic tolerance to morphine. Valproic acid was administered 60 min prior to morphine injection.

, 2021
(A-B) Tolerance to morphine was developed by repeated injections, while pretreatment with valproic acid one hour before each morphine injection inhibited the expression of tolerance to morphine.
Yaghoub Fathollahi (778334), Forough Foolad (8626191), Seyed Hossein Marashi (11414828), Mohammad Javan (195590), Ghazaleh Ghamkharinejad (11414825)   +4 more
core   +1 more source

Role of D1/D2 dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in rats

Biomolecules & Biomedicine, 2013
While opioid receptors have been implicated in the development of tolerance, the subsequent mechanisms involved in these phenomena have not been completely understood.
Ercan Ozdemir, Ihsan Bagcivan, Sinan Gursoy   +2 more
doaj   +1 more source

Morphine-induced antinociception and tolerance: Spinal versus supraspinal actions.

, 1989
Morphine-induced antinociception and tolerance: Spinal versus supraspinal ...
Judith A. Siuciak (2219068)
core   +2 more sources