Results 11 to 20 of about 685,770 (240)
Emerging roles of microRNAs in morphine tolerance
Journal of Pain Research, 2019 Jiangju Huang, Jian Wang, Qulian Guo, Wangyuan ZouDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of ChinaAbstract: Morphine is commonly used in clinical management to alleviate ...
Huang J, Wang J, Guo Q, Zou W
doaj +5 more sources
GABAB receptors within the central nucleus of amygdala may involve in the morphine-induced incentive tolerance in female rats [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Central nucleus of amygdala (CeA) is the most important region for morphine-induced reward, and GABAergic system plays an important role on morphine reinforcement. The influence of CeA administration of GABAB receptor agonist and antagonist
Firoozeh Alavian, Saeedeh Ghiasvand
doaj +3 more sources
The Emerging Perspective of Morphine Tolerance: MicroRNAs
Pain Research and Management, 2019 Morphine has unfavorable side effects including analgesic tolerance. Morphine tolerance counteracts analgesic efficacy and drives dose escalation. The mechanisms underlying morphine tolerance remain disputed, which has prevented the development of ...
Teng J. Zhang, Yong Qiu, Zhen Hua
doaj +2 more sources
Phosphoproteomics and bioinformatics analyses of spinal cord proteins in rats with morphine tolerance. [PDF]
PLoS ONE, 2014 Morphine is the most effective pain-relieving drug, but it can cause unwanted side effects. Direct neuraxial administration of morphine to spinal cord not only can provide effective, reliable pain relief but also can prevent the development of ...
Wen-Jinn Liaw +7 more
doaj +2 more sources
Targeting exosomal double-stranded RNA-TLR3 signaling pathway attenuates morphine tolerance and hyperalgesia [PDF]
Cell Reports MedicineSummary: Long-term morphine use leads to tolerance and hyperalgesia in patients with chronic pain, with neuroinflammation playing a key role, but its underlying mechanisms remain elusive.
Bing Wang +11 more
doaj +2 more sources
Reverse of Acute and Chronic Morphine Tolerance by Lithocholic Acid via Down-regulating UGT2B7 [PDF]
Frontiers in Pharmacology, 2016 Lithocholic acid (LCA) deposited in human livers always induces drastic pains which need analgesic drug, like morphine to release. Our research showed that LCA can effectively inhibit uridine 5'-diphospho-glucuronosyltransferase 2B7 (UGT2B7) in morphine ...
Zizhao Yang +7 more
doaj +2 more sources
Journal of Pain Research, 2017 Haiqin Li, Rong Tao, Jing Wang, Lingjie Xia Department of Clinical Pain, The People’s Hospital of Henan Province, Zhengzhou, People’s Republic of China Abstract: Several lines of evidence indicate that microRNAs (miRNAs ...
Li HQ, Tao R, Wang J, Xia LJ
doaj +1 more source
Delay of Morphine Tolerance by Palmitoylethanolamide [PDF]
BioMed Research International, 2015 In spite of the potency and efficacy of morphine, its clinical application for chronic persistent pain is limited by the development of tolerance to the antinociceptive effect. The cellular and molecular mechanisms underlying morphine tolerance are complex and still unclear.
DI CESARE MANNELLI, LORENZO +4 more
openaire +2 more sources
Xylopic acid from Xylopia aethiopica (Annonaceae) inhibits morphine tolerance in rats [PDF]
Pharmaceutical Sciences Asia, 2022 Traditionally, Xylopia aethiopica is used to manage pain disorders such as neuralgia, colic pain, rheumatism and headache. Using animal models, this study aimed to investigate the ability of Xylopic Acid (XA), a kaurene diterpene obtained from Xylopia ...
Priscilla Kolibea Mante +7 more
doaj +1 more source
Integrative Cancer Therapies, 2021 Purpose: Morphine is often used for the treatment of moderate and severe cancer pain, but long-term use can lead to morphine tolerance. Methods for effectively inhibiting morphine tolerance and the related mechanism of action are of great significance ...
Bin Jiang MD +8 more
doaj +1 more source