Results 11 to 20 of about 23,947 (195)
Emerging roles of microRNAs in morphine tolerance
Journal of Pain Research, 2019 Jiangju Huang, Jian Wang, Qulian Guo, Wangyuan ZouDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of ChinaAbstract: Morphine is commonly used in clinical management to alleviate ...
Huang J, Wang J, Guo Q, Zou W
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Delay of Morphine Tolerance by Palmitoylethanolamide [PDF]
BioMed Research International, 2015 In spite of the potency and efficacy of morphine, its clinical application for chronic persistent pain is limited by the development of tolerance to the antinociceptive effect. The cellular and molecular mechanisms underlying morphine tolerance are complex and still unclear.
DI CESARE MANNELLI, LORENZO +4 more
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Xylopic acid from Xylopia aethiopica (Annonaceae) inhibits morphine tolerance in rats [PDF]
Pharmaceutical Sciences Asia, 2022 Traditionally, Xylopia aethiopica is used to manage pain disorders such as neuralgia, colic pain, rheumatism and headache. Using animal models, this study aimed to investigate the ability of Xylopic Acid (XA), a kaurene diterpene obtained from Xylopia ...
Priscilla Kolibea Mante +7 more
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GABAB receptors within the central nucleus of amygdala may involve in the morphine-induced incentive tolerance in female rats [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Central nucleus of amygdala (CeA) is the most important region for morphine-induced reward, and GABAergic system plays an important role on morphine reinforcement. The influence of CeA administration of GABAB receptor agonist and antagonist
Firoozeh Alavian, Saeedeh Ghiasvand
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Integrative Cancer Therapies, 2021 Purpose: Morphine is often used for the treatment of moderate and severe cancer pain, but long-term use can lead to morphine tolerance. Methods for effectively inhibiting morphine tolerance and the related mechanism of action are of great significance ...
Bin Jiang MD +8 more
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Frontiers in Pharmacology, 2022 Acutely, non-selective cannabinoid (CB) agonists have been shown to increase morphine antinociceptive effects, and we and others have also demonstrated that non-selective CB agonists attenuate morphine antinociceptive tolerance. Activation of cannabinoid
Zachary W. Reichenbach +10 more
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Functionally selective signaling for morphine and fentanyl antinociception and tolerance mediated by the rat periaqueductal gray. [PDF]
PLoS ONE, 2014 Functionally selective signaling appears to contribute to the variability in mechanisms that underlie tolerance to the antinociceptive effects of opioids.
Michael M Morgan +2 more
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PLoS ONE, 2021 Backgroundɣ-aminobutyric acid (GABA) facilitator valproic acid may be able to curb memory disruption induced by morphine exposure.ObjectiveThe effects of the GABA facilitator valproic acid on the behavioral tolerance induced by morphine were investigated.
Ghazaleh Ghamkharinejad +4 more
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The effect of metformin on morphine analgesic tolerance and dependence in rats
Research in Pharmaceutical Sciences, 2018 Opiate tolerance and dependence is a worldwide public health problem and gives a significant burden to society. The aim of this study was to evaluate the effects of metformin (MET) on development and expression of morphine tolerance and dependence in ...
Iman Fatemi +3 more
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Phosphoproteomics and bioinformatics analyses of spinal cord proteins in rats with morphine tolerance. [PDF]
PLoS ONE, 2014 Morphine is the most effective pain-relieving drug, but it can cause unwanted side effects. Direct neuraxial administration of morphine to spinal cord not only can provide effective, reliable pain relief but also can prevent the development of ...
Wen-Jinn Liaw +7 more
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