Results 121 to 130 of about 51,793 (252)
Health Science Reports, Volume 9, Issue 3, March 2026.ABSTRACT Background and Aims Effective pain management remains a critical component of emergency care. However, patient‐related beliefs and misconceptions about pain medication can pose significant barriers to adequate analgesia. The aim of the study was to assess patient‐reported barriers to pain medication use and outcome in an emergency setting in ...
Stephen Mensah Arhin +7 more
wiley +1 more source
Journal of Surgical Oncology, Volume 133, Issue 4, Page 421-432, March 15, 2026.ABSTRACT Background and Objective Palliative surgery in oncology aims to relieve symptoms, improve quality of life, and respect patient autonomy in advanced cancer. This study aimed to develop evidence‐based recommendations for safely indicating and performing palliative surgeries in Brazil, considering clinical, ethical, and multidisciplinary aspects.
Audrey Cabral Ferreira de Oliveira +15 more
wiley +1 more source
MicroRNAs in Methamphetamine: Addiction, Neurotoxicity, and Therapeutic Potential
MedComm – Future Medicine, Volume 5, Issue 1, March 2026.The use of METH leads to the release of dopamine from the affected brain regions, including the nucleus accumbens (NAc), ventral tegmental area (VTA), prefrontal cortex (PFC), hippocampus (Hip), and striatum. This triggers signals that alter miRNA expression, which in turn leads to differential expression of target genes.
Yacoubou Abdoul Razak Mahaman +7 more
wiley +1 more source
Emerging roles of microRNAs in morphine tolerance
Journal of Pain Research, 2019 Jiangju Huang, Jian Wang, Qulian Guo, Wangyuan ZouDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of ChinaAbstract: Morphine is commonly used in clinical management to alleviate ...
Huang J, Wang J, Guo Q, Zou W
doaj
Local Anesthetics in Cancer: Mechanisms and Translational Perspectives
MedComm – Oncology, Volume 5, Issue 1, March 2026.Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang +4 more
wiley +1 more source
Naringenin may prevent morphine-induced tolerance via inhibiting glycogen synthase kinase-3beta activity in mice [PDF]
Journal of Medicinal PlantsBackground: Opioids are essential for pain treatment, but their long-term usage results in tolerance. Naringenin, a natural flavonoid found in fruit, inhibits the enzyme that causes opioid tolerance, making it effective in treating neurodegenerative ...
Samira Shirooie +6 more
doaj
Changes in the Gene Expression of β1 and β2 Integrins Following Development of Tolerance to Analgesic Effect of Morphine in Rats [PDF]
Cell Journal, 2010 Objective: Considering the inhibitory effect of integrin-activity modulator (manganese) onthe development of morphine tolerance; in this study we have tried to assess the effectof chronic administration of both morphine and manganese on the expression ...
Jamal Ghorbi +2 more
doaj
Dose-Dependent Enhancement of Morphine-Induced Analgesia\ud by Ingestion of Amniotic Fluid and Placenta [PDF]
, 1988 Ingestion of amniotic fluid and placenta by rats has been shown to enhance opioid-mediated analgesia. The present studies were designed to examine the effect of several doses and volumes of placenta and amniotic fluid on tail-flick latency in rats ...
Abbott, Patricia +2 more
core
Paediatric and Neonatal Pain, Volume 8, Issue 1, March 2026.ABSTRACT Pediatric pain remains one of the inadequately managed conditions in clinical practice, especially in low‐resource settings, due in part to limited training across health professions. Addressing this gap requires a coordinated, multidisciplinary approach to improve pain assessment and management in children.
Abigail Kusi Amponsah +11 more
wiley +1 more source
Global Emergency Medicine: A Scoping Review of the Literature From 2024
Academic Emergency Medicine, Volume 33, Issue 3, March 2026.ABSTRACT Objective The Global Emergency Medicine Literature Review (GEMLR) identifies impactful research in global emergency care. This 20th annual edition reviews GEM literature published in 2024 and highlights the growth of GEMLR over the years. Methods We conducted a scoping review of 2024 GEM articles through structured PubMed and gray literature ...
J. Austin Lee +85 more
wiley +1 more source