Results 11 to 20 of about 51,793 (252)

Yokukansan Inhibits the Development of Morphine Tolerance by Regulating Presynaptic Proteins in DRG Neurons [PDF]

Frontiers in Pharmacology, 2022
Opioids, such as morphine, are used in clinical settings for the management of acute and chronic pain. However, long-term use of morphine leads to antinociceptive tolerance and hypersensitivity. The cellular and molecular mechanisms of morphine tolerance
Yusuke Ohashi, Fatma Zahra Sakhri, Hideshi Ikemoto, Takayuki Okumo, Naoki Adachi, Masataka Sunagawa   +5 more
doaj   +2 more sources

Xylopic acid from Xylopia aethiopica (Annonaceae) inhibits morphine tolerance in rats [PDF]

Pharmaceutical Sciences Asia, 2022
Traditionally, Xylopia aethiopica is used to manage pain disorders such as neuralgia, colic pain, rheumatism and headache. Using animal models, this study aimed to investigate the ability of Xylopic Acid (XA), a kaurene diterpene obtained from Xylopia ...
Priscilla Kolibea Mante, Kweku Abakah-Ewusi, Amanda Adoley Mingle, Mustapha Seidu Kpienaan, Samuel Offei-Twum, Nana Kofi Kusi-Boadum, Nana Ofori Adomako, Newman Osafo   +7 more
doaj   +1 more source

GABAB receptors within the central nucleus of amygdala may involve in the morphine-induced incentive tolerance in female rats [PDF]

Iranian Journal of Basic Medical Sciences, 2017
Objective(s): Central nucleus of amygdala (CeA) is the most important region for morphine-induced reward, and GABAergic system plays an important role on morphine reinforcement. The influence of CeA administration of GABAB receptor agonist and antagonist
Firoozeh Alavian, Saeedeh Ghiasvand
doaj   +1 more source

Electroacupuncture Attenuates Morphine Tolerance in Rats with Bone Cancer Pain by Inhibiting PI3K/Akt/JNK1/2 Signaling Pathway in the Spinal Dorsal Horn

Integrative Cancer Therapies, 2021
Purpose: Morphine is often used for the treatment of moderate and severe cancer pain, but long-term use can lead to morphine tolerance. Methods for effectively inhibiting morphine tolerance and the related mechanism of action are of great significance ...
Bin Jiang MD, Xuemei Zhong MD, Junfan Fang PhD, Aijun Zhang MD, Wen WangD MD, Yi Liang PhD, Jianqiao Fang PhD, Feng Chen, Junying Du PhD   +8 more
doaj   +1 more source

Modulation of Morphine Analgesia, Antinociceptive Tolerance, and Mu-Opioid Receptor Binding by the Cannabinoid CB2 Receptor Agonist O-1966

Frontiers in Pharmacology, 2022
Acutely, non-selective cannabinoid (CB) agonists have been shown to increase morphine antinociceptive effects, and we and others have also demonstrated that non-selective CB agonists attenuate morphine antinociceptive tolerance. Activation of cannabinoid
Zachary W. Reichenbach, Zachary W. Reichenbach, Kelly DiMattio, Suren Rajakaruna, David Ambrose, William D. Cornwell, Ronald J. Tallarida, Thomas Rogers, Lee-Yuan Liu-Chen, Ronald F. Tuma, Sara Jane Ward   +10 more
doaj   +1 more source

Delay of Morphine Tolerance by Palmitoylethanolamide [PDF]

BioMed Research International, 2015
In spite of the potency and efficacy of morphine, its clinical application for chronic persistent pain is limited by the development of tolerance to the antinociceptive effect. The cellular and molecular mechanisms underlying morphine tolerance are complex and still unclear.
DI CESARE MANNELLI, LORENZO, CORTI, FRANCESCA, MICHELI, LAURA, ZANARDELLI, MATTEO, GHELARDINI, CARLA   +4 more
openaire   +2 more sources

Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]

, 2013
Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Ferenczi, Szilamér, Kovács, Krisztina J., Milanes, Victoria M., Nunez, Cristina, Pintér-Kübler, Bernadett, Polyák, Ágnes, Zelei, Edina   +6 more
core   +9 more sources

Functionally selective signaling for morphine and fentanyl antinociception and tolerance mediated by the rat periaqueductal gray. [PDF]

PLoS ONE, 2014
Functionally selective signaling appears to contribute to the variability in mechanisms that underlie tolerance to the antinociceptive effects of opioids.
Michael M Morgan, Rachel A Reid, Kimber A Saville   +2 more
doaj   +1 more source

Ethanol reversal of tolerance to the respiratory depressant effects of morphine [PDF]

, 2015
Opioids are the most common drugs associated with unintentional drug overdose. Death results from respiratory depression. Prolonged use of opioids results in the development of tolerance but the degree of tolerance is thought to vary between different ...
A Fugelstad, A Fugelstad, Abi Lyndon, AJ Ruttenber, Anne Lingford-Hughes, AR Lingford-Hughes, B Levine, BM Mathers, CA Paronis, Chris Bailey, CK Kuo, CN Lessov, CP Bailey, CP Bailey, CP Bailey, E Kelly, E Valjent, Eamonn Kelly, EB Rex, EJ Waite, F Chen, FL Smith, FL Smith, Graeme Henderson, GS Ling, H Sakakibara, HW Matthes, HY Lin, I Rodriguez-Martin, J Llorente, J McPherson, J Reneau, JM White, Joanne Roberts, John MacLachlan, JT Williams, JW Lewis, KL McGilliard, L He, LC Hull, LC Saland, LJ Sim-Selley, LM Bohn, LQ Hong-Brown, M Aliczki, M Hickman, M Hickman, M Inoue, M Pierce, Matthew Hickman, N Quillinan, NG Shah, R Cornish, R Romberg, Rob Hill, S Darke, S Darke, S Kishioka, Sarah Withey, SJ Slater, SV Dighe, TC Green, Yvonne Kershaw   +62 more
core   +3 more sources

Src Kinase Inhibition Attenuates Morphine Tolerance without Affecting Reinforcement or Psychomotor Stimulation [PDF]

, 2017
BACKGROUND: Prolonged opioid administration leads to tolerance characterized by reduced analgesic potency. Pain management is additionally compromised by the hedonic effects of opioids, the cause of their misuse.
Baptista-Hon, Daniel T., Bull, Fiona A., Hales, Tim G., Sneddon, Claire, Walwyn, Wendy, Wright, Lisa   +5 more
core   +3 more sources