Results 201 to 210 of about 51,793 (252)
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Haloperidol-induced tolerance to morphine catalepsy
Life Sciences, 1977Abstract Morphine (0, 10, 17, 30 mg/kg i.p.) was administered acutely and its cataleptic action tested. Chronic haloperidol 5 mg/kg/day i.p. was then administered to these animals for 14 days. On the 16th day, the animals were retested with morphine. Chronic haloperidol induced tolerance to morphine's cataleptogenic effects.
C, Ezrin-Waters, P, Seeman
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Bulletin of Experimental Biology and Medicine, 2001
We carried out a complex physiological, neurochemical, and neuroimmunologic study of the formation of tolerance to analgetic effect of morphine and analyzed enkephalinase A activity in different brain structures and serotonin antibodies in the serum. More early development of morphine tolerance and a sharp increase in serum antibody titer was found in ...
S V, Litvinova +5 more
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We carried out a complex physiological, neurochemical, and neuroimmunologic study of the formation of tolerance to analgetic effect of morphine and analyzed enkephalinase A activity in different brain structures and serotonin antibodies in the serum. More early development of morphine tolerance and a sharp increase in serum antibody titer was found in ...
S V, Litvinova +5 more
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Endothelin receptor antagonists restore morphine analgesia in morphine tolerant rats
Peptides, 2003Several neurotransmitter mechanisms have been proposed to play a role in the development of morphine tolerance. The present study provides evidence for the first time that endothelin (ET) antagonists can restore morphine analgesia in morphine tolerant rats.
Shaifali, Bhalla +2 more
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Tolerance to morphine stimulus control: role of morphine maintenance dose
Psychopharmacology, 1990Experiments assessed the development of tolerance to morphine stimulus control during treatment with selected maintenance doses of morphine. Separate groups of rats were trained to discriminate saline and either 3.2 mg/kg or 5.6 mg/kg morphine under fixed-ratio schedules of food delivery.
A M, Young +5 more
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Tolerance to morphine analgesia
Pain Forum, 1999There is a growing body of evidence that implicates the role of excitatory amino acids (EEAs), in particular the N-methyl-D-aspartate (NMDA) receptor, in the development of opioid tolerance. In their Focus article, Fundytus and Coderre have proposed a model of opioid tolerance that highlights the importance of metabotropic glutamate receptors (MGIuRs ...
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Cross-tolerance to cannabinoids in morphine-tolerant rhesus monkeys
Psychopharmacology, 2015Opioids remain the drugs of choice for treating moderate to severe pain, although adverse effects limit their use. Therapeutic utility might be improved by combining opioids with other drugs to enhance analgesic effects, but only if adverse effects are not similarly changed.Cannabinoids have been shown to enhance the antinociceptive potency of opioids ...
L R, Gerak +3 more
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Cross-Tolerance between Ethanol and Morphine
1980Adult male Wistar rats were fed chronically a liquid diet providing 35% of the calories as ethanol (10-12 g/kg ethanol daily), while pair-fed controls received the corresponding diet with alcohol replaced by an equicaloric concentration of sucrose. Rectal temperatures, after test doses of ethanol or morphine, were measured in several groups of rats at ...
A D, Lê +3 more
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Morphine‐3‐glucuronide prevents tolerance to morphine‐6‐glucuronide in mice
European Journal of Pain, 1997Daily subcutaneous (s.c.) pretreatment with morphine‐3‐glucuronide (6 mg/kg) was found to reduce morphine‐6‐glucuronide (4 mg/kg s.c.)‐induced antinociception, with no decrease in the effect over 5 days. Morphine‐6‐glucuronide administration (4 mg/kg s.c.) on Day 6, without morphine‐3‐glucorinide pretreatment, results in a significant increase in ...
Faura, Clara C. +2 more
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Extinction of morphine analgesic tolerance
Learning and Motivation, 1980Abstract It has been suggested that the analgesic effect of morphine becomes attenuated over the course of successive administrations by a conditional, compensatory, hyperalgesic response elicited by the administration procedure, thus accounting (in part) for analgesic tolerance.
Shepard Siegel +2 more
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Peripheral morphine analgesia resistant to tolerance in chronic morphine-treated mice
Neuroscience Letters, 1999Intraplantarly (i.pl.)-injected morphine showed a peripheral analgesia in experiments to assess the blockade of bradykinin (i.pl.)-induced nociceptive flexor response in mice. The peripheral morphine analgesia in mice which developed central analgesic tolerance to chronic morphine (10 mg/kg s.c., 5 days), was equivalent to that in vehicle-treated mice ...
H, Ueda, M, Inoue
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