PLoS ONE, 2021 Backgroundɣ-aminobutyric acid (GABA) facilitator valproic acid may be able to curb memory disruption induced by morphine exposure.ObjectiveThe effects of the GABA facilitator valproic acid on the behavioral tolerance induced by morphine were investigated.
Ghazaleh Ghamkharinejad +4 more
doaj +1 more source
Interactions of (2S,6S;2R,6R)-Hydroxynorketamine, a Secondary Metabolite of (R,S)-Ketamine, with Morphine [PDF]
, 2018 Ketamine and its primary metabolite norketamine attenuate morphine tolerance by antagonising N-methyl-d-aspartate (NMDA) receptors. Ketamine is extensively metabolized to several other metabolites.
Adams +44 more
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Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat [PDF]
, 2015 Background and Purpose The effects of ketamine in attenuating morphine tolerance have been suggested to result from a pharmacodynamic interaction. We studied whether ketamine might increase brain morphine concentrations in acute coadministration, in ...
Coffman BL +6 more
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The effect of metformin on morphine analgesic tolerance and dependence in rats
Research in Pharmaceutical Sciences, 2018 Opiate tolerance and dependence is a worldwide public health problem and gives a significant burden to society. The aim of this study was to evaluate the effects of metformin (MET) on development and expression of morphine tolerance and dependence in ...
Iman Fatemi +3 more
doaj +1 more source
Phosphoproteomics and bioinformatics analyses of spinal cord proteins in rats with morphine tolerance. [PDF]
PLoS ONE, 2014 Morphine is the most effective pain-relieving drug, but it can cause unwanted side effects. Direct neuraxial administration of morphine to spinal cord not only can provide effective, reliable pain relief but also can prevent the development of ...
Wen-Jinn Liaw +7 more
doaj +1 more source
PolyMorphine provides extended analgesic-like effects in mice with spared nerve injury. [PDF]
, 2017 Morphine is a well-characterized and effective analgesic commonly used to provide pain relief to patients suffering from both acute and chronic pain conditions.
Chen, Renxun +5 more
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BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates [PDF]
, 2019 © 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have
Cami-Kobeci, Gerta +9 more
core +5 more sources
Role of D1/D2 dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in rats
Biomolecules & Biomedicine, 2013 While opioid receptors have been implicated in the development of tolerance, the subsequent mechanisms involved in these phenomena have not been completely understood.
Ercan Ozdemir +2 more
doaj +1 more source
Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]
, 2013 Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Birkás, Erika +12 more
core +3 more sources
M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes [PDF]
, 2017 Morphine inefficiency to induce the internalization of mu opioid (MOP) receptors observed in numerous experimental models constitutes a paradigm of G-protein coupled receptor (GPCR) functional selectivity.
Alvarez-Curto, Elisa +2 more
core +1 more source