Results 61 to 70 of about 51,793 (252)

The Role of Spinal PKCγ in Tolerance and Hyperalgesia Induced by Repeated Morphine Administration in Male Rats

Iranian South Medical Journal, 2018
Background: The aim of this study was to investigate the possible role of Protein Kinase Cᵧ (PKCᵧ) in morphine tolerance and induced hyperalgesia following repeated morphine administration in male rats.  Material and Methods: Rats were divided into
Kobra Ghasemloo, Homa Manaheji, Lila Dargahi, Sareh pandamooz   +3 more
doaj  

Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation

Journal of Neuroinflammation, 2017
Background Long-term use of morphine induces analgesic tolerance, which limits its clinical efficacy. Evidence indicated morphine-evoked neuroinflammation mediated by toll-like receptor 4 (TLR4) - NOD-like receptor protein 3 (NLRP3) inflammasome was ...
Jie Qu, Xue-You Tao, Peng Teng, Yan Zhang, Ci-Liang Guo, Liang Hu, Yan-Ning Qian, Chun-Yi Jiang, Wen-Tao Liu   +8 more
doaj   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Identification of lncRNA expression profiles and ceRNA analysis in the spinal cord of morphine-tolerant rats

Molecular Brain, 2018
Morphine tolerance is a challenging clinical problem that limits the use of morphine in pain treatment, but the mechanisms of morphine tolerance remain unclear.
Jiali Shao, Jian Wang, Jiangju Huang, Chang Liu, Yundan Pan, Qulian Guo, Wangyuan Zou   +6 more
doaj   +1 more source

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

Phytotherapy Research, EarlyView.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli, Giovanni Roviello, Giorgia Magliocca, Emilia Esposito, Anna Pannaccione   +4 more
wiley   +1 more source

Ingested bovine amniotic fluid enhances morphine antinociception in rats [PDF]

, 2000
Ingestion by rats of rat placenta or amniotic fluid enhances opioid-mediated, or partly opioid-mediated, antinociception produced by morphine injection, vaginal or cervical stimulation, late pregnancy, and foot shock.
Corpening, James W., Doerr, Jean C., Kristal, Dr. Mark B.   +2 more
core   +1 more source

Comparing leukocyte‐ and thrombocyte‐rich fibrin and autologous grafts for the treatment of experimentally induced wounds in the tarsometatarsus of chickens

Veterinary Record, EarlyView.
Abstract Background Managing open wounds in birds is challenging. This study compared leukocyte‐ and thrombocyte‐rich fibrin (L‐TRF) and autologous grafts for treating wounds in the tarsometatarsus of chickens. Methods Full‐thickness wounds were experimentally induced in the tarsometatarsus of 23 healthy adult chickens.
Vivian Ferreira Rech, Sheila Canevese Rahal, Renata Dalcol Mazaro, Luna Scarpari Rolim, Guilherme Rech Cassanego, Matheus Yuri Dos Santos, Rafael Almeida Fighera   +6 more
wiley   +1 more source

AAKD: A standardized and comprehensive acupuncture anesthesia knowledge platform for enhanced recovery after surgery and mechanism

VIEW, EarlyView.
Acupuncture anesthesia (AA) is an application of acupuncture innovation in surgical operations, combined with anesthetic techniques, and is a model of integrated Chinese and Western medicine. We proposed the Acupuncture Anesthesia Knowledge Database (AAKD), in which all data have been meticulously curated by field experts and assessed by a multi ...
Ying Wang, Honglian Huang, Chenchen Feng, Xueli Zhang, Weiting Wang, Ziyi Wei, Jing Li, Xintong Yu, Hanzhi Lu, Chunfang Gao, Ke Wang, Jia Zhou   +11 more
wiley   +1 more source

The effect of morphine upon DNA methylation in ten regions of the rat brain [PDF]

, 2017
Morphine is one of the most effective analgesics in medicine. However, its use is associated with the development of tolerance and dependence. Recent studies demonstrating epigenetic changes in the brain after exposure to opiates have provided insight ...
Baccarelli, A, Barrow, Timothy, Byun, HM, Guo, L, Li, X, Smart, C, Wang, YX, Zhang, Y   +7 more
core   +1 more source

Determinants of Compliance to Enhanced Recovery Protocol After Emergency Laparotomy

World Journal of Surgery, EarlyView.
Enhanced Recovery protocols (ERP) are comprehensive, evidence‐based approaches aimed at accelerating patient recovery and improving surgical results; increasing evidence exists about their adoption in emergency laparotomy. The study aimed to evaluate the compliance to the proposed postoperative pathway and the determinants of late recovery.
Marco Ceresoli, Chiara Fumagalli, Alan Biloslavo, Antonio La Greca, Michele Carlucci, Giovanni Pesenti, Savino Occhionorelli, Pietro Bisagni, Carlo Feo, Dario Tartaglia, Dario Parini, Matteo Runfola, Riccardo Somigli, Diego Visconti, Diego Mariani, Diletta Cassini, Andrea Mingoli, Marco Braga, On behalf of the Study Collaborative Group   +18 more
wiley   +1 more source