Concomitant with the opioid epidemic, there has been a rise in pregnant women diagnosed with opioid use disorder and infants born with neonatal opioid withdrawal syndrome (NOWS).
Kelly K. Wingfield +10 more
doaj +1 more source
Confronting the opioid crisis: Practical pain management and strategies: AOA 2018 critical issues symposium [PDF]
The United States is in the midst of an opioid crisis. Clinicians have been part of the problem because of overprescribing of narcotics for perioperative pain management.
Hsu, Joseph R +4 more
core +1 more source
Role of Orexin in the Tolerance and Physical Dependence to Morphine
BACKGROUND AND OBJECTIVE: Although opioid drugs cause analgesia and more effective in treatment of pain but, its utility is hindered by the development of tolerance to its analgesic effects.
Samad Nazemi +2 more
doaj
Altered Plasma and Brain Disposition and Pharmacodynamics of Methadone in Abstinent Rats [PDF]
The pharmacokinetics and pharmacodynamics of methadone were investigated in control and abstinent rats. Minipumps filled with saline (control group) or saline-morphine (abstinent group) solutions were used to induce physical dependence.
Calvo, R. (Rosario) +3 more
core
Background: Ocimum basilicum showed antinociceptive activity. The antinociceptive effect was inhibited by naloxone in hot-plate test. Objective: As O.
H Hosseinzadeh, M Ramezani, Z Afarin
doaj
Increased mRNA Expression for the α\u3csub\u3e1\u3c/sub\u3e Subunit of the GABA\u3csub\u3eA\u3c/sub\u3e Receptor Following Nitrous Oxide Exposure in Mice [PDF]
The mechanisms by which nitrous oxide (N2O) produces physical dependence and withdrawal seizures are not well understood, but both N2O and ethanol exert some of their effects via the GABAA receptor and several lines of evidence indicate that withdrawal ...
Cullinan, William E. +2 more
core +1 more source
Background and Objective: There is complex interaction between corticosteroids and opioid system receptors. This study was designed to investigate the interaction between the effect of Dexamethasone (DEX) and morphine in opioid physical dependence in rat.
TP Kalantari Pour, N Atapour
doaj
Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids. [PDF]
Tramadol is one of the most commonly used analgesics worldwide, classified as having a low abuse potential by U.S. Drug Enforcement Agency, and often recommended in pain management guidelines.
Abagyan, Ruben +3 more
core +1 more source
Attenuation of Morphine Withdrawal Syndrome by Prosopis Farcta Extract and Its Bioactive Component Luteolin in Comparison with Clonidine in Rats. [PDF]
Moayeri A +4 more
europepmc +1 more source
Effect of hydro-alcoholic extract of Teucrium polium, Descurainia sophia and Artemisia aucheri on naloxone-precipitated morphine withdrawal in male rat [PDF]
زمینه و هدف: سندرم ترک یکی از عوارض خطرناک و بحرانی سوء استفاده از مواد مخدر است و درمان آن از اولویتهای بهداشتی و درمانی محسوب می شود. هدف این مطالعه بررسی اثر عصاره خاکشیر، درمنه و کلپوره بر علائم ناشی از سندرم ترک مورفین می باشد.
Allahtavakoli, Mohammad. +7 more
core

