Results 11 to 20 of about 452,240 (289)

The mechanics of plant morphogenesis

Science, 2023
Understanding the mechanism by which patterned gene activity leads to mechanical deformation of cells and tissues to create complex forms is a major challenge for developmental biology.
E. Coen, D. Cosgrove
semanticscholar   +1 more source

3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insert

Nature Protocols, 2022
Human intestinal morphogenesis establishes 3D epithelial microarchitecture and spatially organized crypt–villus characteristics. This unique structure is necessary to maintain intestinal homeostasis by protecting the stem cell niche in the basal crypt ...
Woojung Shin, Hyun Jung Kim
semanticscholar   +1 more source

Actin-based force generation and cell adhesion in tissue morphogenesis.

Current Biology, 2021
The generation of organismal form - morphogenesis - arises from forces produced at the cellular level. In animal cells, much of this force is produced by the actin cytoskeleton.
D. N. Clarke, Adam C. Martin
semanticscholar   +1 more source

Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells

Nature Communications, 2020
SARS-CoV-2, a β-coronavirus, has rapidly spread across the world, highlighting its high transmissibility, but the underlying morphogenesis and pathogenesis remain poorly understood.
N. Zhu, Wenling Wang, Zhidong Liu, C. Liang, Wen Wang, F. Ye, Baoying Huang, Li Zhao, Huijuan Wang, Wei-min Zhou, Yao Deng, Longfei Mao, C. Su, Guangliang Qiang, T. Jiang, Jincun Zhao, Guizhen Wu, Jingdong Song, W. Tan   +18 more
semanticscholar   +1 more source

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome

Nature Communications, 2021
Leigh syndrome (LS) is a severe manifestation of mitochondrial disease in children and is currently incurable. The lack of effective models hampers our understanding of the mechanisms underlying the neuronal pathology of LS. Using patient-derived induced
Gizem Inak, A. Rybak-Wolf, P. Lisowski, T. Pentimalli, R. Jüttner, Petar Glažar, K. Uppal, E. Bottani, D. Brunetti, Christopher Secker, Annika Zink, D. Meierhofer, Marie-Thérèse Henke, Monishita Dey, Ummi Ciptasari, Barbara Mlody, T. Hahn, Maria Berruezo-Llacuna, Nikos Karaiskos, M. Di Virgilio, J. Mayr, S. Wortmann, J. Priller, M. Gotthardt, Dean P. Jones, E. Mayatepek, W. Stenzel, Sebastian Diecke, R. Kühn, E. Wanker, N. Rajewsky, M. Schuelke, A. Prigione   +32 more
semanticscholar   +1 more source

Synthetic Morphogenesis [PDF]

Cold Spring Harbor Perspectives in Biology, 2016
Throughout biology, function is intimately linked with form. Across scales ranging from subcellular to multiorganismal, the identity and organization of a biological structure's subunits dictate its properties. The field of molecular morphogenesis has traditionally been concerned with describing these links, decoding the molecular mechanisms that give ...
Brian P, Teague, Patrick, Guye, Ron, Weiss   +2 more
openaire   +2 more sources

The transpeptidase PBP2 governs initial localization and activity of the major cell-wall synthesis machinery in E. coli

eLife, 2020
Bacterial shape is physically determined by the peptidoglycan cell wall. The cell-wall-synthesis machinery responsible for rod shape in Escherichia coli is the processive 'Rod complex'.
Gizem Özbaykal, Eva Wollrab, Francois Simon, Antoine Vigouroux, Baptiste Cordier, Andrey Aristov, Thibault Chaze, Mariette Matondo, Sven van Teeffelen   +8 more
doaj   +1 more source

Immunocompetent Mice Infected by Two Lineages of Dengue Virus Type 2: Observations on the Pathology of the Lung, Heart and Skeletal Muscle

Microorganisms, 2021
Dengue virus (DENV) infection by one of the four serotypes (DENV-1 to 4) may result in a wide spectrum of clinical manifestations, with unpredictable evolution and organ involvement.
Fernanda Cunha Jácome, Gabriela Cardoso Caldas, Arthur da Costa Rasinhas, Ana Luisa Teixeira de Almeida, Daniel Dias Coutinho de Souza, Amanda Carlos Paulino, Marcos Alexandre Nunes da Silva, Derick Mendes Bandeira, Ortrud Monika Barth, Flavia Barreto dos Santos, Debora Ferreira Barreto-Vieira   +10 more
doaj   +1 more source

Morphological Aspects and Viremia Analysis of BALB/c Murine Model Experimentally Infected with Dengue Virus Serotype 4

Viruses, 2021
Ever since its brief introduction in the Brazilian territory in 1981, dengue virus serotype 4 (DENV-4) remained absent from the national epidemiological scenario for almost 25 years. The emergence of DENV-4 in 2010 resulted in epidemics in most Brazilian
Arthur da Costa Rasinhas, Fernanda Cunha Jácome, Gabriela Cardoso Caldas, Ana Luisa Teixeira de Almeida, Marcos Alexandre Nunes da Silva, Daniel Dias Coutinho de Souza, Amanda Carlos Paulino, Derick Mendes Bandeira, Raphael Leonardo, Priscila Conrado Guerra Nunes, Ronaldo Mohana-Borges, Ortrud Monika Barth, Flavia Barreto dos Santos, Debora Ferreira Barreto Vieira   +13 more
doaj   +1 more source

Neuroepithelial organoid patterning is mediated by a neighborhood watch mechanism

Cell Reports, 2023
Summary: During epithelial tissue patterning, morphogens operate across multiple length scales to instruct cell identities. However, how cell fate changes are coordinated over these scales to establish spatial organization remains poorly understood. Here,
Abdel Rahman Abdel Fattah, Sergei Grebenyuk, Laura P.M.H. de Rooij, Idris Salmon, Adrian Ranga   +4 more
doaj   +1 more source