Results 11 to 20 of about 378,865 (268)
Development, 2020 ABSTRACT Over the past 5 years, several studies have begun to uncover the links between the classical signal transduction pathways and the physical mechanisms that are used to sculpt branched tissues. These advances have been made, in part, thanks to innovations in live imaging and reporter animals.
Katharine Goodwin, Celeste M. Nelson
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Morphogenesis at criticality [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Biological networks are described by many parameters, and the behavior of a network is qualitatively different (monostable, bistable, oscillating, etc.) in different parts of parameter space. Critical points and surfaces are the borders between such qualitatively different regimes, as with phase ...
Krotov, Dmitry +3 more
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GEOMETRY OF MORPHOGENESIS [PDF]
BIOMAT 2014, 2015 We introduce a formalism for the geometry of eukaryotic cells and organisms.Cells are taken to be star-convex with good biological reason. This allows for a convenient description of their extent in space as well as all manner of cell surface gradients.
Morozova, Nadya, Penner, Robert
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WormBook, 2005 The morphogenesis of the C. elegans embryo is largely controlled by the development of the epidermis, also known as the hypodermis, a single epithelial layer that surrounds the animal. Morphogenesis of the epidermis involves cell-cell interactions with internal tissues, such as the developing nervous system and musculature.
Andrew D, Chisholm, Jeff, Hardin
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Development, 1993 ABSTRACT The Drosophila position specific (PS) integrins consist of two cell surface heterodimers, PS1 (αPS1βPS) and PS2 (αPS2βPS), which are expressed on complementary sides of attachments between cell layers and are essential for these attachments.
Brown, Nicholas H. +3 more
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Neuroepithelial organoid patterning is mediated by a neighborhood watch mechanism
Cell Reports, 2023 Summary: During epithelial tissue patterning, morphogens operate across multiple length scales to instruct cell identities. However, how cell fate changes are coordinated over these scales to establish spatial organization remains poorly understood. Here,
Abdel Rahman Abdel Fattah +4 more
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npj Regenerative Medicine, 2023 The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive. Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin signaling is highly disrupted post-radiation.
Alejandro M. Chibly +13 more
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A method to generate the surface cell layer of the 3D virtual shoot apex from apical initials
Plant Methods, 2017 Background The development of cell pattern in the surface cell layer of the shoot apex can be investigated in vivo by use of a time-lapse confocal images, showing naked meristem in 3D in successive times. However, how this layer is originated from apical
Krzysztof Kucypera +3 more
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Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes
Nature Communications, 2019 Pericytes are perivascular cells essential for blood-brain barrier maintenance. Here Diéguez-Hurtado et al. show that depletion of the transcription factor RBPJ in pericytes affects their molecular identity and disturbs endothelial cell behaviour ...
Rodrigo Diéguez-Hurtado +13 more
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Induction of osteogenesis by bone-targeted Notch activation
eLife, 2022 Declining bone mass is associated with aging and osteoporosis, a disease characterized by progressive weakening of the skeleton and increased fracture incidence.
Cong Xu +15 more
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