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, 2023 These thesis will argue about the importance of Dynamic Parametric Architecture versus Static Parametric Architecture. Describing the architectonical and the algorithmic context within which the Emergency Deployable System emerged, it will be discussed the importance of adaptability as the missing concept of parametric architecture.
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A model of morphogenesis [PDF]
Physica A: Statistical Mechanics and its Applications, 2004 A new suggestion for pattern formation in biological systems is proposed. The interaction of two signaling pathways provides complex patterning. The interaction of two pathways involves few of the biochemical complexities of the pathways. The 'Wnt' pathway is proposed to be one of these, in interaction with others, one at a time, perhaps sequentially ...
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Cell & Bioscience, 2023 Background Animal regeneration is the natural process of replacing or restoring damaged or missing cells, tissues, organs, and even entire body to full function. Studies in mammals have revealed that many organs lose regenerative ability soon after birth
Shouhong Wang +7 more
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Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo
Nature, 2018 Collective cell migration is essential for morphogenesis, tissue remodelling and cancer invasion. In vivo, groups of cells move in an orchestrated way through tissues.
E. Barriga +3 more
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Nature Communications, 2023 Exocrine acinar cells in salivary glands (SG) are critical for oral health and loss of functional acinar cells is a major clinical challenge. Fibroblast growth factor receptors (FGFR) are essential for early development of multiple organs, including SG ...
Marit H. Aure +6 more
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Induction of osteogenesis by bone-targeted Notch activation
eLife, 2022 Declining bone mass is associated with aging and osteoporosis, a disease characterized by progressive weakening of the skeleton and increased fracture incidence.
Cong Xu +15 more
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Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain
eLife, 2022 The blood-brain barrier (BBB) limits the entry of leukocytes and potentially harmful substances from the circulation into the central nervous system (CNS). While BBB defects are a hallmark of many neurological disorders, the cellular heterogeneity at the
Hyun-Woo Jeong +7 more
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Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes
Nature Communications, 2019 Pericytes are perivascular cells essential for blood-brain barrier maintenance. Here Diéguez-Hurtado et al. show that depletion of the transcription factor RBPJ in pericytes affects their molecular identity and disturbs endothelial cell behaviour ...
Rodrigo Diéguez-Hurtado +13 more
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Protection of Artemisia annua roots and leaves against oxidative stress induced by arsenic
Biologia Plantarum, 2017 The present study was conducted to examine differential responses of roots and leaves of Artemisia annua to different arsenic concentrations (50, 100, and 150 μΜ) and treatment durations (1, 3, 5, or 7 d).
A. Kumari, N. Pandey, S. Pandey-Rai
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Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1
Nature Communications, 2017 Pericytes are essential for the development, maintenance and function of vascular networks. Here, Eilken and colleagues show that expression of the decoy receptor VEGFR1 by pericytes spatially restricts VEGF signalling, thus regulating VEGF-induced ...
Hanna M. Eilken +8 more
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