Results 21 to 30 of about 452,240 (289)
Circulation Research, 2008 Tubular structures are a fundamental anatomic theme recurring in a wide range of animal species. In mammals, tubulogenesis underscores the development of several systems and organs, including the vascular system, the lungs, and the kidneys.
Arie, Horowitz, Michael, Simons
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Nature Communications, 2017 Asymmetric nuclear positioning in the fruit fly oocyte is essential for the correct localization of axis determinants. Here, the authors show that different microtubule-dependent mechanisms contribute to nuclear transport and ensure the robustness of ...
Nicolas Tissot +9 more
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npj Regenerative Medicine, 2023 The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive. Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin signaling is highly disrupted post-radiation.
Alejandro M. Chibly +13 more
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A method to generate the surface cell layer of the 3D virtual shoot apex from apical initials
Plant Methods, 2017 Background The development of cell pattern in the surface cell layer of the shoot apex can be investigated in vivo by use of a time-lapse confocal images, showing naked meristem in 3D in successive times. However, how this layer is originated from apical
Krzysztof Kucypera +3 more
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Morphogenesis at criticality [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Biological networks are described by many parameters, and the behavior of a network is qualitatively different (monostable, bistable, oscillating, etc.) in different parts of parameter space. Critical points and surfaces are the borders between such qualitatively different regimes, as with phase transitions in ...
Krotov, Dmitry +3 more
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Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo
Nature, 2018 Collective cell migration is essential for morphogenesis, tissue remodelling and cancer invasion. In vivo, groups of cells move in an orchestrated way through tissues.
E. Barriga +3 more
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Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes
Nature Communications, 2019 Pericytes are perivascular cells essential for blood-brain barrier maintenance. Here Diéguez-Hurtado et al. show that depletion of the transcription factor RBPJ in pericytes affects their molecular identity and disturbs endothelial cell behaviour ...
Rodrigo Diéguez-Hurtado +13 more
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Induction of osteogenesis by bone-targeted Notch activation
eLife, 2022 Declining bone mass is associated with aging and osteoporosis, a disease characterized by progressive weakening of the skeleton and increased fracture incidence.
Cong Xu +15 more
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Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain
eLife, 2022 The blood-brain barrier (BBB) limits the entry of leukocytes and potentially harmful substances from the circulation into the central nervous system (CNS). While BBB defects are a hallmark of many neurological disorders, the cellular heterogeneity at the
Hyun-Woo Jeong +7 more
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Cell & Bioscience, 2023 Background Animal regeneration is the natural process of replacing or restoring damaged or missing cells, tissues, organs, and even entire body to full function. Studies in mammals have revealed that many organs lose regenerative ability soon after birth
Shouhong Wang +7 more
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