Morphogenesis at criticality [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Biological networks are described by many parameters, and the behavior of a network is qualitatively different (monostable, bistable, oscillating, etc.) in different parts of parameter space. Critical points and surfaces are the borders between such qualitatively different regimes, as with phase transitions in ...
Krotov, Dmitry +3 more
openaire +3 more sources
Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes
Nature Communications, 2019 Pericytes are perivascular cells essential for blood-brain barrier maintenance. Here Diéguez-Hurtado et al. show that depletion of the transcription factor RBPJ in pericytes affects their molecular identity and disturbs endothelial cell behaviour ...
Rodrigo Diéguez-Hurtado +13 more
doaj +1 more source
Induction of osteogenesis by bone-targeted Notch activation
eLife, 2022 Declining bone mass is associated with aging and osteoporosis, a disease characterized by progressive weakening of the skeleton and increased fracture incidence.
Cong Xu +15 more
doaj +1 more source
MADS-box genes controlling inflorescence morphogenesis in sunflower [PDF]
, 2008 MADS-box genes play an important role in plant ontogeny, particularly, in the regulation of floral organ induction and development. Eight full-length cDNAs of HAM genes (Helianthus annuus MADS) have been isolated from sunflower.
Angenent, G.C. +3 more
core +9 more sources
Simulations demonstrate a simple network to be sufficient to control branch point selection, smooth muscle and vasculature formation during lung branching morphogenesis [PDF]
, 2012 Proper lung functioning requires not only a correct structure of the conducting airway tree, but also the simultaneous development of smooth muscles and vasculature.
Cellière, Géraldine +2 more
core +3 more sources
Cell & Bioscience, 2023 Background Animal regeneration is the natural process of replacing or restoring damaged or missing cells, tissues, organs, and even entire body to full function. Studies in mammals have revealed that many organs lose regenerative ability soon after birth
Shouhong Wang +7 more
doaj +1 more source
Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain
eLife, 2022 The blood-brain barrier (BBB) limits the entry of leukocytes and potentially harmful substances from the circulation into the central nervous system (CNS). While BBB defects are a hallmark of many neurological disorders, the cellular heterogeneity at the
Hyun-Woo Jeong +7 more
doaj +1 more source
PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex [PDF]
, 2017 PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β ...
Anderson +82 more
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Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo
Nature, 2018 Collective cell migration is essential for morphogenesis, tissue remodelling and cancer invasion. In vivo, groups of cells move in an orchestrated way through tissues.
E. Barriga +3 more
semanticscholar +1 more source
A modified Oster-Murray-Harris mechanical model of morphogenesis [PDF]
, 2013 There are two main modeling paradigms for biological pattern formation in developmental biology: chemical prepattern models and cell aggregation models. This paper focuses on an example of a cell aggregation model, the mechanical model developed by Oster,
Benjamin L. Vaughan +6 more
core +1 more source