Results 121 to 130 of about 4,458,570 (286)

Optimized micro‐sized cell sphere‐matrix niche co‐aggregates promote efficient oral and craniomaxillofacial bone regeneration

BMEMat, EarlyView.
The construct of cell‐niche co‐aggregates (GelMA‐SHED sphere‐DDMPs) promotes cranial and periodontal bone regeneration and ensures angiogenic‐osteogenic coupling by downregulating miR‐34c‐5p to enhance the expression of NOTCH1 and its intracellular domain (NICD).
Xiao‐Hui Zhang, Shi‐Han Mu, Yi‐Han Xiao, Lu‐Fan Yang, Peng‐Fei Wang, Teng‐Fei Hu, Jun‐Xi He, Jiong‐Zhen Piao, Sha Zhang, Jin‐Yu Liu, Yi‐De He, Ying‐Ying Wu, Si‐Qi Ying, Xin‐Yue Cai, Chen‐Han Li, Zi‐Qi Zhang, Xiao Lei, Ji Chen, Jian‐Fei Liang, Yan Jin, Bing‐Dong Sui, Chao Ma, Chen‐Xi Zheng, Fang Jin   +23 more
wiley   +1 more source

Safety and Effectiveness of Recombinant Human Bone Morphogenetic Protein-2 for Spinal Fusion:A Meta-analysis of Individual-Participant Data

, 2013
Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used to promote fusion in spinal surgery, but its safety has been ...
Simmonds, Mark C, Higgins, Julian P T, Mannion, Richard J, Stewart, Lesley A, Brown, Jennifer V E, Heirs, Morag K, Rodgers, Mark A   +6 more
core   +1 more source

Harnessing bacterial extracellular vesicles for bone and cartilage organoids

BMEMat, EarlyView.
This review presents bacterial extracellular vesicles (BEVs) as programmable bioactive regulators for bone and cartilage organoids by delivering functional cargos that modulate skeletal remodeling. It highlights key engineering strategies and future directions to advance next‐generation organoid models for bone aging related diseases.
Han Liu, Xukun Lv, Ting Cheng, Lei Yan, Yuxiao Lai, Keying Guo, Yingying Jing, Hao Shen, Jiacan Su   +8 more
wiley   +1 more source

Dose reduction of bone morphogenetic protein-2 for bone regeneration using a delivery system based on lyophilization with trehalose

, 2018
Xiaochen Zhang,1,* Quan Yu,2,* Yan-an Wang,1 Jun Zhao2 1Department of Oral and Maxillofacial-Head and Neck Oncology, 2Department of Orthodontics, College of Stomatology, Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University ...
Wang YA, Zhang X, Yu Q, Zhao J
core  

Nanotopographical cues mechanically regulate the secretion and osteoinductive potential of MSC‐derived exosomes for bone regeneration

BMEMat, EarlyView.
A defined 700 nm low‐density nanotopographical interface mechanically primes MSCs through the integrin β1–focal adhesion–Akt–Rab27a‐dependent pathway, enhancing exosome secretion and osteoinductive potency. Enrichment of miR‐548d‐5p in these exosomes promotes osteogenic differentiation and bone regeneration, establishing nanotopography‐guided MSC ...
Ziqi Zhang, Limeng Zheng, Zehui Xu, Xiaoyang Han, Guangli Xiang, Yizeng Chang, Hong Chen, Mo Yang, Wai Yin Cheng, Nathanael Chun Him Lai, Weihao Yuan, Siu Hong Dexter Wong, Bohan Yin   +12 more
wiley   +1 more source

The osteogenesis of bacterial cellulose scaffold loaded with bone morphogenetic protein-2.

, 2012
Bacterial cellulose (BC) is a nanofibrous biological material with attractive physicochemical properties and biocompatibility. Its fiber is similar to the collagenous fiber of bone.
Lei Chen, Yang Li, Hua Zhang, Zhaoxu Wang*, Qin Shi(施勤), Jie Sun(孙杰), Bing Chen, Huilin Yang   +7 more
core  

Detection, identification and in vivo treatment responsiveness of bone morphogenetic protein (BMP)-activated cell populations in the synovium of patients with rheumatoid arthritis.

, 2008
To characterise the bone morphogenetic protein (BMP) target cells positive for phosphorylated (P)-SMAD1/5, in rheumatoid arthritis (RA ...
Durez, Patrick, Daans, M., Westhovens, R., Verschueren, P.C., Théate, I., Lories, R.J.U., Luyten, F.P., R J U Lories, P Durez, P C P M Verschueren, I Théate, R Westhovens, M Daans, F P Luyten   +13 more
core   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell–cell junctions during neural tube formation

Developmental Dynamics, EarlyView.
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Derrick Thomas, Brittany M. Hufft‐Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J. Tran, Jianming Xu, Irfan Saadi, Walid D. Fakhouri   +8 more
wiley   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source