Results 141 to 150 of about 4,458,570 (286)

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Bone morphogenetic protein 12: a novel target for cardiovascular disease. [PDF]

Mol Biomed
Isaza SC, Hernández-García MÁ, Fernández-García CE, Pérez-Utrera C, Álvarez-Rubal M, Muñoz JM, Friera A, García-Monzón C, Gómez-Hernández A, Landete P, Egea J, Alfonso F, González-Rodríguez Á.   +12 more
europepmc   +1 more source

Hepatocyte‐Centered Regulation of MASH Fibrosis: From Animal Models to Molecular Mechanisms and Targeted Therapies

iNew Medicine, EarlyView.
This review highlights hepatocytes as active regulators of MASH fibrosis through secreted proteins, metabolites, and extracellular vesicles that modulate hepatic stellate cell activation. These hepatocyte–stellate cell communication pathways provide a mechanistic framework for developing targeted antifibrotic therapies, including hepatocyte‐directed ...
Eui Jung Jung, Xiaobo Wang
wiley   +1 more source

Bone morphogenetic protein signaling as a key regulator of retinal fibrosis. [PDF]

Proc Natl Acad Sci U S A
Sharma S, Alahdab G, Haque MN, Karkoukli I, Assaf A, Ishida Y, Abu Elasrar A, Moustafa M, Tarek M, Zhang X, Mitton KP, Josifovska N, Petrovski G, Ueharu H, Mishina Y, Al-Shabrawey M.   +15 more
europepmc   +1 more source

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

Evaluation of Bone Regeneration by Sustained Release of Bone Morphogenetic Protein from Porous Polyetheretherketone. [PDF]

Int J Mol Sci
Shiotani Y, Jo JI, Takasugi S, Adachi T, Yasui K, Hashimoto Y, Nishiura A.   +6 more
europepmc   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Human Bone Morphogenetic Protein-3 Mature Ligand Is Larger Than Recorded Indicating Earlier Publications Are Flawed. [PDF]

FASEB J
Phelan DE, Scaife C, Dorris ER, Russell J, Murphy M.   +4 more
europepmc   +1 more source

Testing for Burden in a Macroevolutionary System

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Evolutionary changes in the fundamental components of the bivalve body plan are not restricted to the early part of their evolutionary history. ABSTRACT The traits defining organismal body plans are expected to acquire burden, approaching invariance as they accumulate characters that depend on them, developmentally and functionally.
David Jablonski, Stewart M. Edie
wiley   +1 more source

Bone Morphogenetic Protein 7-Loaded Gelatin Methacrylate/Oxidized Sodium Alginate/Nano-Hydroxyapatite Composite Hydrogel for Bone Tissue Engineering [PDF]

Shiyuan Huang, Zesen Wang, Xudong Sun, Kuanxin Li The First Affiliated Hospital of Bengbu Medical University, Bengbu Medical University, Bengbu, Anhui Province, 233044, People’s Republic of ChinaCorrespondence: Kuanxin Li, The First Affiliated Hospital ...
Huang S, Sun X, Li K, Wang Z
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