Results 31 to 40 of about 4,458,570 (286)
Nature Communications, 2022 Here the authors show that a monoclonal antibody against a soluble isoform of Bone Morphogenetic Protein 1 prevents cardiac cell death, reducing fibrosis and preserving cardiac function after myocardial ischemia.
Slobodan Vukicevic +15 more
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Frontiers in MicrobiologyClostridium sporogenes is an anaerobic spore-forming bacterium genetically related to Clostridium botulinum but lacks toxin genes. The sporulation mechanism and spore structures of anaerobic bacteria, including C.
Ritsuko Kuwana +4 more
doaj +1 more source
Haematologica, 2009 Background The circulating hormone hepcidin plays a central role in iron homeostasis. Our goal was to establish an ex vivo iron-sensing model and to characterize the molecular mechanisms linking iron to hepcidin.Design and Methods Murine hepatocytes were
Guillemette Ramey +2 more
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Intracellular amyloid beta expression leads to dysregulation of the mitogen-activated protein kinase and bone morphogenetic protein-2 signaling axis. [PDF]
PLoS ONE, 2018 Alzheimer's disease (AD) is a neurodegenerative syndrome classically depicted by the parenchymal accumulation of extracellular amyloid beta plaques. However, recent findings suggest intraneuronal amyloid beta (iAβ1-42) accumulation precedes extracellular
Eric Cruz +4 more
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Blood, 2009 Abstract BMP2 and BMP4 play crucial inductive roles during development. In this issue of Blood, Shao et al demonstrate that an intricate network of paracrine BMP2/4 signals also regulates angiogenesis—and will very likely interact with endocrine BMP cues during wound repair ...
openaire +3 more sources
The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillofacial trauma
Chinese Journal of Traumatology, 2017 In recent years, recombinant human bone morphogenetic protein-2 (rhBMP-2) has been introduced as a therapeutic option in the treatment of several congenital and acquired craniofacial defects.
A.S. Herford
doaj +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Accelerators of Osteogenesis by Recombinant Human Bone Morphogenetic Protein-2
Drug Target Insights, 2007 Bone morphogenetic protein (BMP) appears to be one of the most promising cytokine and for clinical use in reconstructive surgery for bony defects and augmentation.
Yasunori Okubo +2 more
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Glypicans Dally and Dally-like control injury-induced allodynia in
Molecular Pain, 2019 Over 100 million people are challenged by the effects of chronic pain in the United States alone. This burden also impacts the U.S. economy; 600 billion dollars annually is spent on medical care, medications, and lost productivity in the workplace ...
Courtney L Brann +2 more
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Biomolecules, 2023 Despite the plethora of research that exists on recombinant human bone morphogenetic protein-2 and -7 (rhBMP-2 and rhBMP-7) and has been clinically approved, there is still a need to gain information that would allow for their more rational use in bone ...
Magdalena Wytrwal +6 more
doaj +1 more source