Results 191 to 200 of about 29,476 (244)

Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines.

Journal of Medicinal Chemistry, 2018
In this article, we report our investigation of a phenomenon by which bridging morpholines across the ring with one-carbon tethers leads to a counterintuitive reduction in lipophilicity.
S. Degorce, M. Bodnarchuk, I. Cumming, James S. Scott   +3 more
semanticscholar   +1 more source

Photocatalytic Synthesis of Substituted 2-Aryl Morpholines via Diastereoselective Annulation.

Journal of the American Chemical Society
Morpholines are prevalent in medicinal chemistry due to their favorable pharmacokinetic properties and widespread presence in FDA-approved drugs. Existing methods for morpholine synthesis often require prefunctionalized or protected reagents, limiting ...
Tiffany A Brisco, Simon De Kreijger, Vaishnavi N Nair, L. Troian‐Gautier, U. Tambar   +4 more
semanticscholar   +1 more source

Green Synthesis of Morpholines via Selective Monoalkylation of Amines.

Journal of the American Chemical Society
Morpholines are common heterocycles in pharmaceutical and agricultural products, yet methods to synthesize them from 1,2-amino alcohols are inefficient.
Kacey G Ortiz, Andrew T Brusoe, Jason An, Eugene Chong, Lifen Wu   +4 more
semanticscholar   +1 more source

Selective, Catalytic, and Dual C(sp3)-H Oxidation of Piperazines and Morpholines under Transition-Metal-Free Conditions.

Journal of Organic Chemistry, 2018
By using cheap and innocuous reagents, such as NaClO2, NaOCl, and catalytic amounts of TEMPO, a new environmentally friendly protocol for the selective and catalytic TEMPO C(sp3)-H oxidation of piperazines and morpholines to 2,3-diketopiperazines (2,3 ...
Delfino Chamorro‐Arenas, Urbano Osorio-Nieto, L. Quintero, L. Hernandez-Garcia, Fernando Sartillo‐Piscil   +4 more
semanticscholar   +1 more source

Organocatalytic Desymmetric Double Aza-Michael Addition Cascade: Enantioselective Synthesis of Fused Morpholines.

Organic Letters
Double aza-Michael addition (DAM) has become an emerging strategy for the construction of two carbon-nitrogen bonds in a single step, which can significantly simplify the synthesis of N-heterocycles.
Sachin S Gorad, P. Ghorai
semanticscholar   +1 more source

A One-Pot Reaction toward the Diastereoselective Synthesis of Substituted Morpholines.

Organic Letters, 2018
The diastereoselective synthesis of various substituted morpholines has been achieved from vinyloxiranes and amino-alcohols under sequential Pd(0)-catalyzed Tsuji-Trost/Fe(III)-catalyzed heterocyclization.
T. Aubineau, J. Cossy
semanticscholar   +1 more source

Synthesis and Evaluation of the in vitro Antimicrobial Activity of Triazoles, Morpholines and Thiosemicarbazones.

Medicinal chemistry, 2019
BACKGROUND Microbial infections is a global public health problem. The aim of this work was to synthesize and evaluate the antimicrobial activity of novel triazoles, morpholines and thiosemicarbazones.
Felipe R. S. Santos, Jéssica T Andrade, C. D. Sousa, Joice S Fernandes, L. F. Carmo, Marcelo G F Araújo, J. M. Ferreira, J. A. Villar   +7 more
semanticscholar   +1 more source

Morpholine-2,5-dione

Acta Crystallographica Section C Crystal Structure Communications, 2006
In the title compound, C4H5NO3, the morpholine ring adopts a boat conformation that is distorted towards twist-boat, the boat ends being the two Csp3 atoms of the ring. The molecular packing is stabilized by the establishment of strong intermolecular NH...OC hydrogen bonds, which give rise to centrosymmetric dimers, and a network of weak CH2...OC ...
Meritxell, Martínez-Palau, Lourdes, Urpí, Xavier, Solans, Jordi, Puiggalí   +3 more
openaire   +2 more sources

4-(2,4-Dinitrophenylsulfanyl)morpholine

Acta Crystallographica Section C Crystal Structure Communications, 2006
In the title compound, C10H11N3O5S, the 2,4-dinitro­phenyl fragment is connected by an S atom to the morpholine ring, which is in a chair conformation. The ortho- and para-nitro groups are slightly twisted out of the plane of the benzene ring. The mol­ecules are linked into C(7) and C(10) chains by two inter­molecular C—H⋯O hydrogen bonds.
Iván, Brito, Matías, López-Rodríguez, Alejandro, Cárdenas, Danitza, Vargas   +3 more
openaire   +2 more sources

Morpholine

2023
Philip H. Howard, Gloria W. Sage, William F. Jarvis, D. Anthony Gray   +3 more
openaire   +1 more source