Results 111 to 120 of about 1,795,685 (335)

motifDiverge: a model for assessing the statistical significance of gene regulatory motif divergence between two DNA sequences

open access: yes, 2014
Next-generation sequencing technology enables the identification of thousands of gene regulatory sequences in many cell types and organisms. We consider the problem of testing if two such sequences differ in their number of binding site motifs for a ...
Friedrich, Tara   +3 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Studi Perbandingan Motif-motif Sosial Dominan Mahasiswa Program Studi Penjaskesrek, Psikologi Pendidikan dan Bimbingan, dan Pendidikan Biologi Fkip Universitas Haluoleo [PDF]

open access: yes, 2011
Keragaman yang cukup mencolok dalam sikap dan perilaku sehari-hari mahasiswa di beberapa program studi di FKIP Universitas Haluoleo menimbulkan pertanyaan tentang motif sosial di Balik perilaku kelompok-kelompok mahasiswa tersebut.
Suarni, W. O. (Wa)
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

DEKONSTRUKSI MOTIF BATIK KERATON CIREBON: PENGARUH RAGAM HIAS KERATON PADA MOTIF BATIK CIREBON

open access: yesJurnal Penelitian Pendidikan, 2015
Motif batik Keraton Cirebon memiliki makna simbolik dan filosofis yang mengandung pesan moral. Ide dasar batik keraton adalah dari ragam hias Keraton Cirebon, naskah dan mushaf Al-qur’an pada Abad 20.
Agus Nursalim
doaj  

Structural and functional analysis of the GABARAP interaction motif (GIM)

open access: yesbioRxiv, 2016
Through the canonical LC3 interaction motif (LIR), [W/F/Y]-X1-X2-[I/L/V], protein complexes are recruited to autophagosomes to perform their functions as either autophagy adaptors or receptors.
V. Rogov   +11 more
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Multi-Scale Heart Beat Entropy Measures for Mental Workload Assessment of Ambulant Users

open access: yesEntropy, 2019
Mental workload assessment is crucial in many real life applications which require constant attention and where imbalance of mental workload resources may cause safety hazards.
Abhishek Tiwari   +6 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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