Redox regulation of motile cilia in airway disease
Redox Biology, 2019 Motile cilia on airway cells are necessary for clearance of mucus-trapped particles out of the lung. Ciliated airway epithelial cells are uniquely exposed to oxidants through trapping of particles, debris and pathogens in mucus and the direct exposure to inhaled oxidant gases.
Michael E. Price, Joseph H. Sisson
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The role of motile cilia in the development and physiology of the nervous system [PDF]
Philos Trans R Soc Lond B Biol Sci, 2019 Motile cilia are miniature, whip-like organelles whose beating generates a directional fluid flow. The flow generated by ciliated epithelia is a subject of great interest, as defective ciliary motility results in severe human diseases called motile ...
Christa Ringers +2 more
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HEATR2 plays a conserved role in assembly of the ciliary motile apparatus. [PDF]
PLoS Genetics, 2014 Cilia are highly conserved microtubule-based structures that perform a variety of sensory and motility functions during development and adult homeostasis.
Christine P Diggle +23 more
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Loss of Rsph9 causes neonatal hydrocephalus with abnormal development of motile cilia in mice [PDF]
Sci Rep, 2020 Hydrocephalus is a brain disorder triggered by cerebrospinal fluid accumulation in brain cavities. Even though cerebrospinal fluid flow is known to be driven by the orchestrated beating of the bundled motile cilia of ependymal cells, little is known ...
Wenzheng Zou +5 more
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Neuronal coordination of motile cilia in locomotion and feeding [PDF]
Philos Trans R Soc Lond B Biol Sci, 2019 Efficient ciliary locomotion and transport require the coordination of motile cilia. Short-range coordination of ciliary beats can occur by biophysical mechanisms.
Milena Marinković +2 more
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Distinct roles of two homologous kinesins in mammalian motile cilia [PDF]
J Cell BiolKaiming Xu, Ming Li, Guangshuo Ou
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Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lung [PDF]
Life Sci AllianceNeenu Joy +15 more
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Impact of Motile Ciliopathies on Human Development and Clinical Consequences in the Newborn
Cells, 2021 Motile cilia are hairlike organelles that project outward from a tissue-restricted subset of cells to direct fluid flow. During human development motile cilia guide determination of the left-right axis in the embryo, and in the fetal and neonatal periods
Rachael M. Hyland, Steven L. Brody
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Cryo-electron tomography of eel sperm flagella reveals a molecular “minimum system” for motile cilia [PDF]
Mol Biol CellJason R. Schrad +5 more
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Airway ciliated cells in adult lung homeostasis and COPD
European Respiratory Review, 2023 Cilia are organelles emanating from the cell surface, consisting of an axoneme of microtubules that extends from a basal body derived from the centrioles. They are either isolated and nonmotile (primary cilia), or grouped and motile (motile cilia). Cilia
Laure M.G. Petit +10 more
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