Results 91 to 100 of about 769,499 (354)

Heterogeneity in Surface Sensing Suggests a Division of Labor in Pseudomonas aeruginosa Populations [PDF]

, 2019
The second messenger signaling molecule cyclic diguanylate monophosphate (c-di-GMP) drives the transition between planktonic and biofilm growth in many bacterial species.
Armbuster, Catherine R., de Anda, Jaime, Harwood, Caroline S., Hoffman, Lucas R., Jin, Fan, Lee, Calvin K., Murakami, Keiji, Parker-Gilham, Jessica, Parsek, Matthew R., Tseng, Boo Shan, Wong, Gerard CL, Xia, Aiguo, Zhao, Kun   +12 more
core   +2 more sources

Exogenous H2S promotes ion channel reconstruction to regulate colonic motility in rats with dinitrobenzene sulfonic acid-induced colitis [PDF]

, 2022
Ying Liu, Ribin Liao, Zhanrong Qiang, Wenjun Yang, Jie Cao   +4 more
openalex   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite opposite effects in heart contraction

Nature Communications
Inherited cardiomyopathies are common cardiac diseases worldwide, leading in the late stage to heart failure and death. The most promising treatments against these diseases are small molecules directly modulating the force produced by β-cardiac myosin ...
Daniel Auguin, Julien Robert-Paganin, Stéphane Réty, Carlos Kikuti, Amandine David, Gabriele Theumer, Arndt W. Schmidt, Hans-Joachim Knölker, Anne Houdusse   +8 more
doaj   +1 more source

Differences in the progression of liver disease in male and female rats induced by TAA: considerations in the development of pharmacological therapies

Annals of Hepatology
Introduction and Objectives: Thioacetamide (TAA) is a hepatotoxic agent that causes fibrosis, cirrhosis, and cancer. Various doses and regimens of TAA have been tested in different murine models to validate hepatoprotective compounds.
Jesús Dorantes-Alvarez, Moisés Martínez-Castillo, Adrián Flores-Sánchez, Ángel García-López, Luz Castro-Hernández, Abigail Hernandez-Barragan, Marisela Hernández-Santillán, Gabriela Gutierrez-Reyes   +7 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Orally active antischistosomal early leads identified from the open access malaria box. [PDF]

, 2014
BACKGROUND: Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of praziquantel resistance underline the need to discover and develop next generation drugs.
A Fenwick, AA Sayed, B Gryseels, B Ramirez, CE Cousin, CJ Murray, E Groll, Gordana Panic, J Keiser, J Keiser, J Keiser, J Keiser, J Keiser, J Keiser, J Utzinger, J Utzinger, JB Correa Soares, Jennifer Keiser, K Ingram, K Ingram, K Waisser, Katrin Ingram-Sieber, L Pica-Mattoccia, MH Abdulla, Mireille Vargas, Noemi Cowan, NR Mansour, Nuha R. Mansour, P Steinmann, Quentin D. Bickle, RA Paveley, S Denoyelle, S Knopp, SD Melman, SH Xiao, SH Xiao, SH Xiao, T Chen, T Manneck, T Spangenberg, Thomas Spangenberg, Timothy G. Geary, Timothy N. C. Wells   +42 more
core   +5 more sources

Binocular and Fellow Eye Acuity Deficits in Amblyopia: Impact of Fixation Instability and Sensory Factors

Journal of Eye Movement Research
Amblyopia, a neurodevelopmental disorder, is commonly assessed through amblyopic eye visual acuity (VA) deficits, but recent studies also highlight abnormalities in the fellow eye. This study quantified binocular and fellow/dominant eye VA in individuals
Yulia Haraguchi, Gokce Busra Cakir, Aasef Shaikh, Fatema Ghasia   +3 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Reactivation of ethanol-calcium-isolated cilia from Tetrahymena pyriformis [PDF]

, 1967
Cilia isolated from Tetrahymena after ciliary shedding is induced by the addition of CaCl2 or other salts to cells suspended in an ethanol solution (4, 6, 11) have been studied chemically and enzymatically (4, 6, 11, 12, 13), but until now have never ...
Winicur, Sandra
core   +2 more sources