Results 21 to 30 of about 419,108 (315)

Myosin 7 and its adaptors link cadherins to actin

Nature Communications, 2017
Cadherin is essential for mechanotransduction and myosin-adaptor-harmonin complexes anchor it to actin. Here the authors present the structures of myosin 7 MF2 domains bound to the harmonin PDZ3c domain and give insights into myosin-adaptor-harmonin ...
I-Mei Yu, Vicente J. Planelles-Herrero, Yannick Sourigues, Dihia Moussaoui, Helena Sirkia, Carlos Kikuti, David Stroebel, Margaret A. Titus, Anne Houdusse   +8 more
doaj   +1 more source

Orbital magnetic resonance imaging is useful in age-related distance esotropia

Journal of Optometry, 2018
Purpose: To describe findings for orbital magnetic resonance imaging (MRI) in patients with age-related distance esotropia (ARDE). Methods: We compared 31 orbital MRI from patients with ARDE (77 ± 7 SD years) with 2 control groups: 32 orbits from ...
Pilar Gómez de Liaño Sanchez, Gloria Olavarri González, Pilar Merino Sanz, Jose C. Escribano Villafruela   +3 more
doaj   +1 more source

Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil

Nature Communications, 2017
Omecamtiv mecarbil (OM) is a cardiac myosin activator that is currently in clinical trials for heart failure treatment. Here, the authors give insights into its mode of action and present the crystal structure of OM bound to bovine cardiac myosin, which ...
Vicente J. Planelles-Herrero, James J. Hartman, Julien Robert-Paganin, Fady I. Malik, Anne Houdusse   +4 more
doaj   +1 more source

High-resolution manometry in patients with and without globus pharyngeus and/or symptoms of laryngopharyngeal reflux

BMC Gastroenterology, 2017
Background Globus pharyngeus is common and has a low cure rate. Its etiology is complex and reported to be associated with laryngopharyngeal reflux (LPR).
Heyan Ding, Zhijun Duan, Dong Yang, Zhifeng Zhang, Lixia Wang, Xiaoyu Sun, Yiwen Yao, Xue Lin, Hang Yang, Shan Wang, Jiande D. Z. Chen   +10 more
doaj   +1 more source

Formation of Aberrant Myotubes by Myoblasts Lacking Myosin VI Is Associated with Alterations in the Cytoskeleton Organization, Myoblast Adhesion and Fusion

Cells, 2020
We have previously postulated that unconventional myosin VI (MVI) could be involved in myoblast differentiation. Here, we addressed the mechanism(s) of its involvement using primary myoblast culture derived from the hindlimb muscles of Snell’s waltzer ...
Lilya Lehka, Małgorzata Topolewska, Dominika Wojton, Olena Karatsai, Paloma Alvarez-Suarez, Paweł Pomorski, Maria Jolanta Rędowicz   +6 more
doaj   +1 more source

Adult reference values of the computerized diplopia test [PDF]

International Journal of Ophthalmology, 2016
AIM: To estimate the adult reference values for measured deviations by a computerized diplopia test and testify the validity. METHODS: Totally 391 participants were recruited and taken the computerized diplopia test.
Ling-Yun Zhou, Tie-Juan Liu, Xue-Mei Li
doaj   +1 more source

Effect of Trainee Participation on Operative Times in Strabismus Surgery

Journal of Academic Ophthalmology, 2022
Introduction This study aimed to describe the difference in operative time during strabismus surgery in the presence and absence of a trainee with the operating physician.
Amgad A. Eldib, Matthew S. Pihlblad
doaj   +1 more source

Transmembrane Protein 100 Inhibits the Progression of Colorectal Cancer by Promoting the Ubiquitin/Proteasome Degradation of HIF-1α

Frontiers in Oncology, 2022
Transmembrane protein 100 (TMEM100) is involved in embryonic cardiovascular system development. However, the biological role of TMEM100 in human cancers, particularly colorectal cancer (CRC), is unclear.
Ying Zheng, Yitong Zhao, Jiong Jiang, Baicang Zou, Lei Dong   +4 more
doaj   +1 more source

Cell Motility [PDF]

Journal of Cell Science, 1986
Approximately 20 years have passed since the first isolation of tubulin, dynein and non-muscle actomyosin. During this period actomyosin, microtubule-dynein or microtubules plus other ATPases (kinesin) have been implicated in almost all cellular motile phenomena.
openaire   +2 more sources

A European Approach to Irritable Bowel Syndrome Management

Canadian Journal of Gastroenterology, 1999
Irritable bowel syndrome (IBS) is characterized by a number of clinical features and probably comprises a cluster of different conditions. The most frequent symptom reported by IBS patients is abdominal pain, although for a number of patients, bowel ...
Michel Delvaux, Jacques Frexinos
doaj   +1 more source