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Amantadine and Motor Fluctuations in Chronic Parkinsonʼs Disease
Clinical Neuropharmacology, 1987Twenty patients with idiopathic Parkinson's disease (PD) and motor fluctuations received open-label amantadine (100-200 mg/d) in addition to their other antiparkinson medications. One patient had unpredictable motor fluctuations (on-off) and the others had end-of-dose wearing-off.
K M, Shannon +4 more
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Motor Fluctuation and Levodopa Absorption
1998Levodopa is the most effective and reliable drug for Parkinson’s disease. Levodopa therapy, however, generally produces motor fluctuation such as wearing-off, on-off, or deterioration of levodopa effects. “Wearing-off” is the most frequently encountered motor fluctuation.
Miho Murata, Ichiro Kanazawa
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Basic mechanisms of motor fluctuations.
Neurology, 1994Patients with Parkinson's disease generally have a smooth clinical response from levodopa therapy for the first 3 to 5 years. Motor fluctuations later become noticeable and may ultimately give way to unpredictable responses to treatment. Mechanisms responsible for motor fluctuations are not fully understood, but can be separated into three groups: (1 ...
J I, Sage, M H, Mark
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Seasonal Fluctuations in the Motor Vehicle Industry: A Comment
The Journal of Industrial Economics, 1973SEASONAL fluctuations in unemployment are generally considered to arise, in the main part, from variations in weather conditions and from movements in demand. A comparison of preand post-war patterns of seasonal variations in the motor industry reveals an interesting example of the influence of changes in production practices, allied to changes in the ...
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Motor fluctuations in parkinson's disease
Annals of Neurology, 1989J G, Nutt, S T, Gancher, W R, Woodward
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Opicapone for motor fluctuations in Parkinson's disease
The Lancet Neurology, 2016David, Devos, Caroline, Moreau
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Gabapentin and motor fluctuations in parkinson's disease
Movement Disorders, 1997P, Chaná, A, de Marinis, N, Barrientos
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Motor fluctuations in Parkinson's disease.
Professional nurse (London, England), 2000People with Parkinson's disease often experience full symptom relief during the first five years of treatment, but motor fluctuations often develop after this. A multidisciplinary team approach will help reduce disability and improve quality of life.
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