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Prevention and treatment of motor fluctuations
Parkinsonism & Related Disorders, 2003The symptoms of Parkinson's disease can become increasingly difficult to control as the disease advances, particularly with the development of motor complications, such as end-of-dose wearing-off and dyskinesias, following long-term therapy. At this stage, the patient is frequently referred to a Parkinson's disease specialist for advice on the ...
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Parkinson’s disease: Motor fluctuations
Current Treatment Options in Neurology, 1999Motor fluctuations represent important late complications of Parkinson's disease treated with levodopa. Although treatment of these problems has improved with the emergence of numerous pharmacologic and surgical therapies, the various options can make it confusing. Pharmacologic treatment is the first step.
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Medical Management of Motor Fluctuations
Neurologic Clinics, 2008Given the magnitude of the problem of motor fluctuations in patients who have Parkinson's disease treated with levodopa, a significant effort has been expended by physicians, researchers, and pharmaceutical manufacturers over the years to find effective treatments.
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Fluctuation theorems and the nonequilibrium thermodynamics of molecular motors
Physical Review E, 2006The fluctuation theorems for the currents and the dissipated work are considered for molecular motors which are driven out of equilibrium by chemical reactions. Because of the molecular fluctuations, these nonequilibrium processes are described by stochastic models based on a master equation.
Andrieux, David, Gaspard, Pierre
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Pathophysiology of motor fluctuations in Parkinson's disease
Movement Disorders, 2005Loss of dopamine neurons in Parkinson's disease (PD) initiates a complex stream of effects that results in the development of tremor, bradykinesia, and rigidity. While levodopa remains the most effective drug for the symptomatic treatment of PD, its chronic administration is associated with the development of motor fluctuations and dyskinesias.
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Management of Motor Fluctuations in Parkinson’s Disease
European Neurology, 2008A complication of chronic levodopa therapy is a shortening of benefit of each dose. Peripheral pharmacokinetics, central pharmacokinetics, and central pharmacodynamics are involved in the pathophysiology of motor fluctuations. Strategies to improve ‘wearing-off fluctuations attempt to provide more constant plasma levodopa levels or more continuous ...
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Revue neurologique, 2003
The therapeutic approach of motor fluctuations is based on the need for recognizing various types of motor fluctuations for each patient by a meticulous interrogation and also to have a good knowledge of the pharmacology of the various anti-parkinsonian drugs.
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The therapeutic approach of motor fluctuations is based on the need for recognizing various types of motor fluctuations for each patient by a meticulous interrogation and also to have a good knowledge of the pharmacology of the various anti-parkinsonian drugs.
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Motor fluctuations in Parkinson's disease
Journal of Neurology, 2007Almost all patients with Parkinson's disease will eventually require levodopa during the course of their disease. The effectiveness of levodopa is evident, but earlier use and higher doses are causative of the emergence of motor fluctuations.
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Levodopa, motor fluctuations and dyskinesia in Parkinson’s disease
Expert Opinion on Pharmacotherapy, 2006Parkinson's disease (PD) is one of the most frequent, chronic, progressive degenerative disorders of the CNS, characterised by altered neurotransmission of dopamine in the basal ganglia. This may result in disturbances of movement, mobility and posture symptoms, all of which cause severe disability in PD patients. There is no cure for PD.
Thomas, Müller, Hermann, Russ
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Cabergoline in Parkinson's disease complicated by motor fluctuations
Movement Disorders, 1996AbstractCabergoline is a long‐acting D2 dopamine (DA) agonist. We conducted an open study to investigate the effectiveness and tolerability of cabergoline, administered once a day orally, in 50 consecutive patients with Parkinson's disease complicated by motor fluctuations and dyskinesias.
G, Geminiani +5 more
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