Results 91 to 100 of about 275,912 (292)

CPI inflation: running on motor fuel [PDF]

Fluctuations in the price of motor fuel (mainly gasoline) have caused most of the monthly noise and year-over-year fluctuations of headline CPI inflation over the past four years.Inflation (Finance) ; Petroleum products ...
William T. Gavin
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Interacting molecular motors: Efficiency and work fluctuations [PDF]

Physical Review E, 2009
We investigate the model of "reversible ratchet" with interacting particles, introduced by us earlier [Europhys. Lett. 84, 50009 (2008)]. We further clarify the effect of efficiency enhancement due to interaction and show that it is of energetic origin, rather than a consequence of reduced fluctuations.
openaire   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Measuring Gait Quality in Parkinson’s Disease through Real-Time Gait Phase Recognition

Sensors, 2018
Monitoring gait quality in daily activities through wearable sensors has the potential to improve medical assessment in Parkinson’s Disease (PD). In this study, four gait partitioning methods, two based on thresholds and two based on a machine learning ...
Ilaria Mileti, Marco Germanotta, Enrica Di Sipio, Isabella Imbimbo, Alessandra Pacilli, Carmen Erra, Martina Petracca, Stefano Rossi, Zaccaria Del Prete, Anna Rita Bentivoglio, Luca Padua, Eduardo Palermo   +11 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Improvement in Motor Consistency and Stability with Foslevodopa/Foscarbidopa in Advanced Parkinson’s Disease: Post Hoc Analysis of Two Phase 3 Clinical Trials

Neurology and Therapy
Introduction People with advanced Parkinson’s disease (aPD) frequently experience unpredictable “Off” time and debilitating motor fluctuations. Foslevodopa/foscarbidopa (LDp/CDp), a levodopa/carbidopa (LD/CD) prodrug, is delivered as a 24-h continuous ...
Rajesh Pahwa, Jason Aldred, Michael J. Soileau, David G. Standaert, Victor S. C. Fung, Thomas Kimber, Irene A. Malaty, Diego Santos-García, Camille Carroll, Tove Henriksen, Ashwini Parab, Connie H. Yan, Maurizio F. Facheris, Amy Spiegel, Linda Harmer, Jorge Zamudio, K. Ray Chaudhuri   +16 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Safinamide in the management of patients with Parkinson’s disease not stabilized on levodopa: a review of the current clinical evidence

Therapeutics and Clinical Risk Management, 2018
Sagari Bette, Danielle S Shpiner, Carlos Singer, Henry Moore Department of Neurology, Division of Parkinson’s Disease and Movement Disorders, University of Miami – Miller School of Medicine, Miami, FL, USA Abstract: Safinamide (Xadago®)
Bette S, Shpiner DS, Singer C, Moore H
doaj  

Distribution and Efficiency of Hydrocarbon-Oxidizing Bacteria in a Freshwater Reservoir [PDF]

, 1984
Hydrocarbon-oxidizing bacteria were identified from three stations on DeGray Reservoir, Arkansas. The organisms were primarily gram-negative rods representing 9 taxa and 37 biotypes Pseudomonas spp. were the most common isolates.
Bragg, Jimmy D., Gosnell, Aubrey B., Smedley, Carol H.   +2 more
core   +2 more sources