Results 81 to 90 of about 6,457 (148)

Interpretable Machine Learning for Cross-Cohort Prediction of Motor Fluctuations in Parkinson s Disease

peer reviewedBackground: Motor fluctuations are a common complication in later stages of Parkinson's disease (PD) and significantly affect patients' quality of life.
Corvol, J.-C., GLAAB, Enrico, Krüger, R., Khoury, F., Pavelka, L., Loo, R.T.J., Vidailhet, M., Mangone, G.   +7 more
core   +1 more source

Effects of Safinamide on Motor and Non-Motor Symptoms in Patients with Parkinson’s Disease and Motor Fluctuations

European Neurology
Introduction: Parkinson’s disease (PD) involves the progressive loss of dopaminergic neurons, leading to motor and non-motor symptoms that significantly impact patients’ quality of life. Safinamide modulates dopaminergic and glutamatergic systems, offering a promising treatment approach.
Kulisevsky, Jaime, Ferraz, Henrique B., Suppa, Antonio, Reichmann, Heinz   +3 more
openaire   +5 more sources

Clinical Outcomes and Predictors of Response to Levodopa–Entacapone–Carbidopa Intestinal Gel in Advanced Parkinson’s Disease: A Retrospective Cohort Study over a 4-Year Period

Pharmaceutics
Background/Objectives: Advanced Parkinson’s disease is characterized by severe motor fluctuations and disabling dyskinesias that often become refractory to conventional oral dopaminergic therapies.
Károly Orbán-Kis, Róbert Máté Szász, Szabolcs Szatmári, Viorelia Adelina Constantin, Simona Maria Bățagă, János Szederjesi, Ilie-Marius Ciorba, Előd Ernő Nagy, Radu Mircea Neagoe, Krisztina Kelemen, Szabolcs Szatmári, Konrád-János Bíró, Nicoleta Crăciun Ciorba, Attila Frigy, József Attila Szász   +14 more
doaj   +1 more source

Nonmotor fluctuations in Parkinson disease: Severity and correlation with motor complications.

, 2013
OBJECTIVE: To evaluate frequency, severity, and correlation of nonmotor symptoms (NMS) with motor complications in fluctuating Parkinson disease (PD). METHODS: The Multicenter NonMotor Fluctuations in PD cross-sectional study used clinical examination of
Schneider, Christine B, Nebe, Angelika, Storch, Alexander, Koch, Rainer, Ebersbach, Georg, Mahler, Andreas, Jost, Wolfgang H, Odin, Per,, Fuchs, Gerd, Stürwald, Yannic, Wolz, Martin, Lund University., Odin, Per, Reichmann, Heinz, Chaudhuri, K Ray   +14 more
core   +1 more source

Randomized trial of safinamide add-on to levodopa in Parkinson's disease with motor fluctuations

, 2014
Levodopa is effective for the motor symptoms of Parkinson's disease (PD), but is associated with motor fluctuations and dyskinesia. Many patients require add-on therapy to improve motor fluctuations without exacerbating dyskinesia.
Pradhan, S, Prabhakar, S., BONUCCELLI, UBALDO, Varma, M, Keshava, B. S., Borgohain, R, Sahadulla, M, Quatrale, R, Varma, M., Krishna Murthy, JM, Kishore, A, Shankar, N, Sethi, PK, Pradhan, S., Prabhakar, SK, Onofrj, M., Kumar Pal, P., Shah, AB, Meshram, C., Vasudevan, D, Eleopra, R., Prabhakar, S. Kr, Bhatt, M., Avarello, T., Kothari, S. S., Sethi, P. K., Forrest, E, Shukla, R, Stanzione, P, Bhatt, M, Rice, P, Anand, R., Giuliani, R., Keshava, BS, Ticmeanu, M, STANZIONE, PAOLO, Pal ,P, Velmurugendran, CU, Vavilikolanu Sreenivas, P., Simu, M., Shukla, R., Anand, R, Popescu, C., Meshram, C, Roy, A. K., Shah, A. B., Giuliani, R, Sowani, A., Ticmeanu, M., Chirileanu, D, Szasz, J., Velmurugendran, C. U., Panea, C., Popescu, C, Stocchi, F., Vijayan, K., Shankar, N., Mehta, N, Sreenivas, P, Kardan, U., Chirileanu, D., Srinivasa, R, Kumar, S., Muresanu, D, Muresanu, D., Bajenaru, O., Campeanu, A., Bajenaru, O, Stanzione, P., Sankhla, C., Sowani, A, Eleopra, R, Roy, AK, Campeanu, A, Vijayan, K, Kothari, SS, Prabhakar, S, Bulboaca, A, Forrest, E., Illiyas Sahadulla, M., Stocchi, F, Avarello, T, Szasz, J, Krishna Murthy, J. M., Bonuccelli, U, Panea, C, Chirilineau, D., Mehta, N., Bulboaca, A., Chirilineau, D, Kishore, A., Rice, P., Vasudevan, D., Sankhla, C, Borgohain, Rupam, Quatrale, R., Onofrj, M, Lucini, V, Kumar, S, Srinivasa, R., Simu, M, Lucini, V., Kardan, U   +102 more
core   +1 more source

Peculiarities of motor fluctuations at different forms of Parkinson's disease

, 2022
Леводопа є одним з найефективніших препаратів для лікування хвороби Паркінсона. На жаль, на сьогодні ще не знайшли леводопи, яка не має побічного впливу на організм при тривалому використанні. Через декілька років прийому даної терапії у більшості хворих
Таряник, Катерина Анатоліївна, Shkodina, A. D., Литвиненко, Наталія Володимирівна, Шкодіна, Анастасія Дмитрівна, Tarianyk, K. A., Lytvenenko, N. V.   +5 more
core  

Profile of inhaled levodopa and its potential in the treatment of Parkinson’s disease: evidence to date

Neuropsychiatric Disease and Treatment, 2018
Ami B Patel, Joohi Jimenez-Shahed Department of Neurology, Baylor College of Medicine, Houston, TX, USA Abstract: Inhaled levodopa is a newly emerging therapeutic option in the treatment of “off” symptoms associated with Parkinson ...
Patel AB, Jimenez-Shahed J
doaj  

Onset and duration of effect of extended-release carbidopa-levodopa in advanced Parkinson’s disease

Neuropsychiatric Disease and Treatment, 2018
Robert A Hauser,1 Aaron Ellenbogen,2 Sarita Khanna,3 Suneel Gupta,3 Nishit B Modi3 1Departments of Neurology, Molecular Pharmacology, and Physiology, University of South Florida, Tampa, FL, USA; 2Quest Research Institute, Bingham Farms, MI, USA; 3Impax ...
Hauser RA, Ellenbogen A, Khanna S, Gupta S, Modi NB   +4 more
doaj  

Factors associated with the development of motor fluctuations and dyskinesias in parkinson disease

Background Motor fluctuations and dyskinesias can cause disability and reduce quality of life for patients with Parkinson disease (PD). Objectives To evaluate factors associated with the development of motor fluctuations and dyskinesias and to assess
Hauser, Robert A
core  

Levodopa in the treatment of Parkinson’s disease: an old drug still going strong

Clinical Interventions in Aging, 2010
Werner Poewe1, Angelo Antonini2, Jan CM Zijlmans3, Pierre R Burkhard4, François Vingerhoets51Department of Neurology, Medical University of Innsbruck, Austria; 2Parkinson Department, IRCCS San Camillo, Venice, and University of Padua, Italy ...
Werner Poewe, Angelo Antonini, Jan CM Zijlmans, et al   +3 more
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