Results 61 to 70 of about 275,912 (292)

Non-equilibrium fluctuations and mechanochemical couplings of a molecular motor

, 2007
We investigate theoretically the violations of Einstein and Onsager relations, and the efficiency for a single processive motor operating far from equilibrium using an extension of the two-state model introduced by Kafri {\em et al.} [Biophys. J. {\bf 86}
A. W. C. Lau, D. Lacoste, J. Howard, K. Mallick   +3 more
core   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Unraveling the fluctuations of animal motor activity [PDF]

Chaos: An Interdisciplinary Journal of Nonlinear Science, 2009
Human and animal behavior exhibits power law correlations whose origin is controversial. In this work, the spontaneous motion of laboratory rodents was recorded during several days. It is found that animal motion is scale-free and that the scaling is introduced by the inactivity pauses both by its length as well as by its specific ordering. Furthermore,
Anteneodo, C., Chialvo, D. R.
openaire   +3 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Practical aspects of prescribing antiparkinsonian drugs. The place of amantadines in the management of Parkinson’s disease

Медицинский совет, 2021
Treatment of Parkinson’s disease (PD) includes the administration of dopaminergic and occasionally non-dopaminergic drugs, in mono- or in combination therapy.
N. V. Titova, A. A. Portupeev
doaj   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Nonthermal fluctuations accelerate biomolecular motors

Biophysical Reviews
AbstractIntracellular transport is essential for maintaining cellular function. This process is driven by different mechanisms in prokaryotic and eukaryotic cells. In small prokaryotic cells, diffusion is the primary means of transport, while larger eukaryotic cells also rely on active transport by molecular motors such as kinesin and dynein. Recently,
openaire   +4 more sources

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source

Fluctuation effects in bidirectional cargo transport

, 2014
We discuss a theoretical model for bidirectional cargo transport in biological cells, which is driven by teams of molecular motors and subject to thermal fluctuations.
Appert-Rolland, Cécile, Klein, Sarah, Santen, Ludger   +2 more
core   +3 more sources

Brownian Carnot engine [PDF]

, 2015
The Carnot cycle imposes a fundamental upper limit to the efficiency of a macroscopic motor operating between two thermal baths. However, this bound needs to be reinterpreted at microscopic scales, where molecular bio-motors and some artificial micro ...
A Bérut, D. Petrov, E Roldán, E Roldán, F Curzon, G Verley, G Verley, GE Crooks, GM Wang, H Ouerdane, I. A. Martínez, IA Martínez, IA Martínez, J Gieseler, J Gieseler, J Howard, J Millen, J Roßnagel, J. M. R. Parrondo, JV Koski, K Proesmans, K Sekimoto, K Sekimoto, K Sekimoto, L. Dinis, M Esposito, M Polettini, M Sarikaya, MVS Bonanca, P Mestres, R Feynman, R. A. Rica, S Carnot, S Toyabe, SM Douglas, TR Gingrich, U Seifert, V Blickle, É. Roldán   +38 more
core   +3 more sources