Results 41 to 50 of about 6,457 (148)

Objective Observer vs. Patient Motor State Assessments Using the PD Home Diary in Advanced Parkinson's Disease

Frontiers in Neurology, 2022
BackgroundThe Parkinson Disease (PD) Home Diary (HD) is a commonly used clinical outcome measure, but it has not been extensively compared to direct assessments by experienced observers.ObjectiveValidation of patient-reported HD by investigating the ...
Jonathan Timpka, Jonathan Timpka, Matthias Löhle, Matthias Löhle, Alexander Bremer, Alexander Bremer, Sofia Christiansson, Sofia Christiansson, Florin Gandor, Florin Gandor, Georg Ebersbach, Örjan Dahlström, Örjan Dahlström, Susanne Iwarsson, Maria H. Nilsson, Maria H. Nilsson, Alexander Storch, Alexander Storch, Per Odin, Per Odin   +19 more
doaj   +1 more source

Fluctuating-friction molecular motors [PDF]

Journal of Physics: Condensed Matter, 2001
to be published in J. Physics Condensed Matter (http://www.iop.org/Journals/JPhysCM)
MARRUCCI, LORENZO, PAPARO D, KREUZER M.
openaire   +3 more sources

Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study [PDF]

, 2023
Non-motor symptoms (NMS) characterize the Parkinson’s disease (PD) clinical picture, and as well as motor fluctuations, PD patients can also experience NMS fluctuations (NMF).
Nicola Biagio Mercuri, Rocco Cerroni, Cerroni, Rocco, De Cillis, Francesca, Matteo Carpi, Stefano Cofano, Alessandro Stefani, Claudio Liguori, Pierantozzi, Mariangela, Carpi, Matteo, Mariangela Pierantozzi, Cofano, Stefano, Francesca De Cillis, Fernandes, Mariana, Liguori, Claudio, Mercuri, Nicola Biagio, Mariana Fernandes, Stefani, Alessandro   +17 more
core   +1 more source

Real-world data of opicapone in patients with Parkinson’s disease experiencing motor fluctuations: the OPTIMO study

Frontiers in Neurology
PurposeEvaluate the outcomes of opicapone as an add-on treatment to levodopa/DDCI in patients with Parkinson’s disease (PD) and motor fluctuations (MF) in a real-world setting.MethodsObservational, retrospective, and post-authorization study in patients ...
María‑Rosario Luquin, Nuria Lopez-Ariztegui, Juan Carlos Martínez Castrillo, Lydia López Manzanares, Isabel Sastre Bataller, Antonio Koukoulis Fernández, Bárbara Vives Pastor, Berta Solano Vila, María Álvarez Sauco, Javier Pagonabarraga Mora, José Matías Arbelo González, Pedro José García Ruiz-Espiga, Oriol de Fàbregues, Javier López del Val, Víctor Campos Arillo, Clara Moreno, José Blanco Ameijeiras, Isabel Pijuan Jiménez, Iciar Tegel Ayuela   +18 more
doaj   +1 more source

Principles of personalized medicine and modern pharmaceutical technologies to optimize levodopa therapy of Parkinson's disease

Анналы клинической и экспериментальной неврологии, 2021
Levodopa (3-hydroxy-L-tyrosine, the levorotatory isomerof 3,4-dihydroxyphenylalanine) is a biological precursor of the neurotransmitter dopamine and has been the "gold standard" in the treatment of Parkinsons disease for over 50 years. The widespread use
Denis А. Abaimov, Ekaterina Yu. Fedotova, Vsevolod V. Poleshchuk, Maksim N. Andreev, Oxana P. Trifonova, Petr G. Lokhov, Sergey N. Illarioshkin   +6 more
doaj   +1 more source

Kaplan-Meier plot of motor fluctuations onset.

, 2016
Lines represent the cumulative motor fluctuations-free survival in years from disease onset.
Pilar Gómez-Garre (215327), Pablo Mir (3605141), Marta Bonilla-Toribio (3605162), Myriam Gómez-Llamas (3605159), Ismael Huertas (3605144), Enrique Calderón (520237), Fátima Carrillo (3605150), Inmaculada Bernal-Bernal (3605135), María Teresa Cáceres-Redondo (3605147), Laura Vargas-González (3605138), Manuel Carballo (3605153), Silvia Jesús (3605156)   +11 more
core   +1 more source

Disease stage dependency of motor and non-motor fluctuations in Parkinson's disease

, 2019
Recent data suggested a decrease in non-motor fluctuations in late-stage Parkinson's disease (PD), but systematic data on non-motor fluctuations over the whole disease course are mainly lacking.
Rosqvist, Kristina, Storch, Alexander, NoMoFlu-PD Study Group, Ebersbach, Georg, Odin, Per   +4 more
core   +1 more source

Nonequilibrium Fluctuations and Mechanochemical Couplings of a Molecular Motor [PDF]

Physical Review Letters, 2007
4 pages, 4 figures, accepted to Phys.
Lau, A. W. C., Lacoste, D., Mallick, K.
openaire   +3 more sources

Patterns and intrinsic fluctuations in semi-dilute motor-filament systems

, 2010
We perform Brownian dynamics simulations of molecular motor-induced ordering and structure formations in semi-dilute cytoskeletal filament solutions. In contrast to the previously studied dilute case where binary filament interactions prevail, the semi ...
F. Ziebert, I. S. Aranson, S. Swaminathan, D. Karpeev   +3 more
core   +1 more source

Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease [PDF]

, 2017
Levodopa is considered to be the most effective symptomatic drug for Parkinson's disease (PD). As the disease progresses, however, the patients are likely to experience a reduced response to levodopa and develop motor fluctuations (i.e., end-of-dose ...
Chao Han, Kai Ma, Nian Xiong, Jie Li, Yun Xia, Shiyi Guo, Jing Y. Liu, Haiyang Jiang, Tao Wang, Luxi Wang, Guoxin Zhang, Jinsha Huang, Ling Liu, Xiaoyun Xu   +13 more
core   +1 more source