Results 41 to 50 of about 275,912 (292)

Inconsistency in serial choice decision and motor reaction times dissociate in younger and older adults [PDF]

, 2004
Intraindividual variability (inconsistency) in reaction time (RT) latencies was investigated in a group of younger (M = 25.46 years) and older (M = 69.29 years) men.
Anstey, Bertelson, Bills, Broadbent, Bunce, Bunce, Cerella, David Bunce, David F. Hultsch, Fozard, Gordon, Hendrickson, Hetherington, Hultsch, Hultsch, Hultsch, Jensen, Knotek, Li, Li, Myerson, Rabbitt, Salthouse, Salthouse, Stollery, Stuart W.S. MacDonald, Stuss, Stuss, Wechsler, Welford, West   +30 more
core   +1 more source

Validation of 24-hour ambulatory gait assessment in Parkinson's disease with simultaneous video observation

BioMedical Engineering OnLine, 2011
Background Parkinson's disease (PD) is a neurodegenerative disorder resulting in motor disturbances that can impact normal gait. Although PD initially responds well to pharmacological treatment, as the disease progresses efficacy often fluctuates over ...
Dilda Valentina, Moore Steven T, Hakim Bandar, MacDougall Hamish G   +3 more
doaj   +1 more source

Assessment of Nonmotor Fluctuations Using a Diary in Advanced Parkinson’s disease

Journal of Parkinson’s Disease, 2016
Background: Since previous studies aimed to study nonmotor symptom (NMS) fluctuations in direct conjunction with motor oscillations, there are no data available on the temporal context of NMS fluctuations and motor oscillations in advanced Parkinson’s ...
Christiana Ossig, Daniel Sippel, Mareike Fauser, Florin Gandor, Wolfgang H. Jost, Georg Ebersbach, Alexander Storch   +6 more
doaj   +1 more source

Comparison of Parkinson’s Disease Patients’ Characteristics by Indication for Deep Brain Stimulation: Men Are More Likely to Have DBS for Tremor

Tremor and Other Hyperkinetic Movements, 2019
Background: We investigated whether the characteristics of Parkinson’s disease (PD) patients differ based on the primary indication for deep brain stimulation (DBS).
W. Alex Dalrymple, Antonia Pusso, Scott A. Sperling, Joseph L. Flanigan, Diane S. Huss, Madaline B. Harrison, W. Jeffrey Elias, Binit B. Shah, Matthew J. Barrett   +8 more
doaj   +1 more source

Active phase and amplitude fluctuations of flagellar beating

, 2014
The eukaryotic flagellum beats periodically, driven by the oscillatory dynamics of molecular motors, to propel cells and pump fluids. Small, but perceivable fluctuations in the beat of individual flagella have physiological implications for ...
Friedrich, Benjamin M., Jülicher, Frank, Klindt, Gary S., Ma, Rui, Riedel-Kruse, Ingmar H.   +4 more
core   +1 more source

Non-equilibrium microtubule fluctuations in a model cytoskeleton

, 2007
Biological activity gives rise to non-equilibrium fluctuations in the cytoplasm of cells; however, there are few methods to directly measure these fluctuations.
Clifford P. Brangwynne, D. Humphrey, D. M. Smith, David A. Weitz, Frederick C. MacKintosh, Gijsje H. Koenderink, L. D. Landau, S. Burlacu   +7 more
core   +3 more sources

Objective Observer vs. Patient Motor State Assessments Using the PD Home Diary in Advanced Parkinson's Disease

Frontiers in Neurology, 2022
BackgroundThe Parkinson Disease (PD) Home Diary (HD) is a commonly used clinical outcome measure, but it has not been extensively compared to direct assessments by experienced observers.ObjectiveValidation of patient-reported HD by investigating the ...
Jonathan Timpka, Jonathan Timpka, Matthias Löhle, Matthias Löhle, Alexander Bremer, Alexander Bremer, Sofia Christiansson, Sofia Christiansson, Florin Gandor, Florin Gandor, Georg Ebersbach, Örjan Dahlström, Örjan Dahlström, Susanne Iwarsson, Maria H. Nilsson, Maria H. Nilsson, Alexander Storch, Alexander Storch, Per Odin, Per Odin   +19 more
doaj   +1 more source

Principles of personalized medicine and modern pharmaceutical technologies to optimize levodopa therapy of Parkinson's disease

Анналы клинической и экспериментальной неврологии, 2021
Levodopa (3-hydroxy-L-tyrosine, the levorotatory isomerof 3,4-dihydroxyphenylalanine) is a biological precursor of the neurotransmitter dopamine and has been the "gold standard" in the treatment of Parkinsons disease for over 50 years. The widespread use
Denis А. Abaimov, Ekaterina Yu. Fedotova, Vsevolod V. Poleshchuk, Maksim N. Andreev, Oxana P. Trifonova, Petr G. Lokhov, Sergey N. Illarioshkin   +6 more
doaj   +1 more source

Entropy production and coarse-graining in Markov processes [PDF]

, 2010
We study the large time fluctuations of entropy production in Markov processes. In particular, we consider the effect of a coarse-graining procedure which decimates {\em fast states} with respect to a given time threshold.
Pigolotti, S., Puglisi, A., Rondoni, L., Vulpiani, A.   +3 more
core   +4 more sources

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source