Results 31 to 40 of about 275,912 (292)

Validation of a Portable Device for Mapping Motor and Gait Disturbances in Parkinson’s Disease

JMIR mHealth and uHealth, 2015
BackgroundPatients with severe idiopathic Parkinson’s disease experience motor fluctuations, which are often difficult to control. Accurate mapping of such motor fluctuations could help improve patients’ treatment.
Rodríguez-Molinero, Alejandro, Samà, Albert, Pérez-Martínez, David A, Pérez López, Carlos, Romagosa, Jaume, Bayés, Àngels, Sanz, Pilar, Calopa, Matilde, Gálvez-Barrón, César, de Mingo, Eva, Rodríguez Martín, Daniel, Gonzalo, Natalia, Formiga, Francesc, Cabestany, Joan, Catalá, Andreu   +14 more
doaj   +1 more source

Opicapone versus placebo in the treatment of Parkinson’s disease patients with end-of-dose motor fluctuation-associated pain: rationale and design of the randomised, double-blind OCEAN (OpiCapone Effect on motor fluctuations and pAiN) trial

BMC Neurology, 2022
Background Optimisation of dopaminergic therapy may alleviate fluctuation-related pain in Parkinson’s disease (PD). Opicapone (OPC) is a third-generation, once-daily catechol-O-methyltransferase inhibitor shown to be generally well tolerated and ...
K. Ray Chaudhuri, Per Odin, Joaquim J. Ferreira, Angelo Antonini, Olivier Rascol, Mónica M. Kurtis, Alexander Storch, Kirsty Bannister, Patrício Soares-da-Silva, Raquel Costa, Diogo Magalhães, José Francisco Rocha   +11 more
doaj   +1 more source

Comparison of the Results of a Parkinson's Holter Monitor With Patient Diaries, in Real Conditions of Use: A Sub-analysis of the MoMoPa-EC Clinical Trial

Frontiers in Neurology, 2022
BackgroundFor specialists in charge of Parkinson's disease (PD), one of the most time-consuming tasks of the consultations is the assessment of symptoms and motor fluctuations.
Carlos Pérez-López, Jorge Hernández-Vara, Nuria Caballol, Nuria Caballol, Àngels Bayes, Mariateresa Buongiorno, Núria Lopez-Ariztegui, Alexandre Gironell, José López-Sánchez, Juan Carlos Martínez-Castrillo, Alvarez Sauco M, Lydia López-Manzanares, Sonia Escalante-Arroyo, David A. Pérez-Martínez, Alejandro Rodríguez-Molinero, The MoMoPa-EC Research Group   +15 more
doaj   +1 more source

Personality dimensions of patients can change during the course of parkinson's disease.

PLoS ONE, 2021
BackgroundStudies assessing personality dimensions by the "Temperament and Character Inventory" (TCI) have previously found an association between Parkinson's disease (PD) and lower Novelty Seeking and higher Harm Avoidance scores.
Mathilde Boussac, Christophe Arbus, Julia Dupouy, Estelle Harroch, Vanessa Rousseau, Aurélie Croiset, Fabienne Ory-Magne, Olivier Rascol, Caroline Moreau, Anne-Sophie Rolland, David Maltête, Tiphaine Rouaud, Mylène Meyer, Sophie Drapier, Bruno Giordana, Mathieu Anheim, Elodie Hainque, Béchir Jarraya, Isabelle Benatru, Nicolas Auzou, Lhaouas Belamri, Mélissa Tir, Ana-Raquel Marques, Stephane Thobois, Alexandre Eusebio, Jean Christophe Corvol, David Devos, Christine Brefel-Courbon, PREDI-STIM study group   +28 more
doaj   +1 more source

The Added Benefit of Opicapone When Used Early in Parkinson's Disease Patients With Levodopa-Induced Motor Fluctuations: A Post-hoc Analysis of BIPARK-I and -II

Frontiers in Neurology, 2021
Introduction: Opicapone (OPC) was efficacious in reducing OFF-time in two pivotal trials in patients with Parkinson's disease (PD) and end-of-dose motor fluctuations (BIPARK-I and -II).
José-Francisco Rocha, Georg Ebersbach, Andrew Lees, Eduardo Tolosa, Joaquim J. Ferreira, Werner Poewe, Olivier Rascol, Fabrizio Stocchi, Angelo Antonini, Diogo Magalhães, Helena Gama, Patrício Soares-da-Silva   +11 more
doaj   +1 more source

Effects of rhythmic auditory stimulation on motor function and balance ability in stroke: A systematic review and meta-analysis of clinical randomized controlled studies

Frontiers in Neuroscience, 2022
ObjectiveRhythmic auditory stimulation (RAS) belongs to neurologic music therapy, which has attracted clinical attention because of its efficacy in motor function after stroke.
Lei Wang, Jin-lin Peng, Wu Xiang, Yi-jie Huang, Ai-lian Chen   +4 more
doaj   +1 more source

How we move is universal: scaling in the average shape of human activity [PDF]

, 2015
Human motor activity is constrained by the rhythmicity of the 24 hours circadian cycle, including the usual 12-15 hours sleep-wake cycle. However, activity fluctuations also appear over a wide range of temporal scales, from days to a few seconds ...
Chialvo, Dante R., Gudowska-Nowak, Ewa, Montoya, Pedro, Nowak, Maciej A., Ochab, Jeremi K., Tagliazucchi, Enzo, Torrado, Ana Maria Gonzalez   +6 more
core   +3 more sources

Genomic Analysis Identifies New Loci Associated With Motor Complications in Parkinson's Disease

Frontiers in Neurology, 2020
Background: Parkinson's disease (PD) is a common neurodegenerative disorder, characterized by a clinical symptomatology involving both motor and non-motor symptoms.
Ho-Sung Ryu, Kye Won Park, Nari Choi, Jinhee Kim, Young-Min Park, Sungyang Jo, Mi-Jung Kim, Young Jin Kim, Juyeon Kim, Kiju Kim, Seong-Beom Koh, Sun Ju Chung   +11 more
doaj   +1 more source

Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson’s Disease: Observations and Dilemmas after 10 Years of Real-Life Experience

Pharmaceutics, 2022
Advanced Parkinson’s disease (APD) cannot be treated efficiently using the classical medications however, in recent decades invasive therapeutical methods were implemented and confirmed as effective. One of these methods makes it possible to continue the
József Attila Szász, Viorelia Adelina Constantin, Károly Orbán-Kis, Ligia Ariana Bancu, Simona Maria Bataga, Marius Ciorba, Előd Nagy, Mircea Radu Neagoe, István Mihály, Róbert Máté Szász, Krisztina Kelemen, Mihaela Simu, Szabolcs Szatmári   +12 more
doaj   +1 more source

Molecular Motors Interacting with Their Own Tracks

, 2007
Dynamics of molecular motors that move along linear lattices and interact with them via reversible destruction of specific lattice bonds is investigated theoretically by analyzing exactly solvable discrete-state ``burnt-bridge'' models.
A. Y. Morozov, Alexander Yu. Morozov, Anatoly B. Kolomeisky, M. N. Artyomov, Max N. Artyomov   +4 more
core   +1 more source