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Anxiety and motor fluctuations in Parkinson's disease: A cross-sectional observational study

Parkinsonism and Related Disorders, 2012
Background: Some studies have suggested a relationship between anxiety and motor fluctuations in patients with Parkinson's disease (PD). Aim: To describe the nature of the relationship between anxiety symptoms and motor fluctuations and to describe the ...
Kathy Dujardin, Laura Marsh, Pablo Martínez-Martín   +2 more
exaly   +2 more sources

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Non‐Motor Fluctuations in Parkinson's Disease: Validation of the Non‐Motor Fluctuation Assessment Questionnaire

Movement Disorders, 2021
ABSTRACTBackgroundIn patients with Parkinson's disease (PD), sleep, mood, cognitive, autonomic, and other non‐motor symptoms may fluctuate in a manner similar to motor symptoms.ObjectivesTo validate a final version of a patient‐rated questionnaire that captures the presence and severity of non‐motor fluctuations in levodopa‐treated PD patients (NoMoFA).
Galit Kleiner, Hubert H. Fernandez, Kelvin L. Chou, Alfonso Fasano, Kevin R. Duque, Diana Hengartner, Albie Law, Adam Margolius, Yu‐Yan Poon, Michel Sáenz Farret, Philip Saleh, Joaquin A. Vizcarra, Glenn T. Stebbins, Alberto J. Espay   +13 more
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Emergence of non-motor fluctuations with reference to motor fluctuations in Parkinson's disease

Parkinsonism & Related Disorders, 2018
Non-motor fluctuations (NMF) and motor fluctuations (MF) are frequent in patients with Parkinson's disease (PD) with long-term medical treatment. We aimed to examine the timing of the emergence of NMF with reference to MF in a prospective cohort of patients with PD without symptom fluctuations.A total of 334 patients with PD who had neither MF nor NMF ...
Aryun Kim, Han-Joon Kim, Chae Won Shin, Ahro Kim, Yoon Kim, Mihee Jang, Yu Jin Jung, Woong-Woo Lee, Hyeyoung Park, Beomseok Jeon   +9 more
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Motor fluctuations in Parkinson’s disease

Journal of the Neurological Sciences, 1999
To assess patterns, prevalence, and risk factors of motor fluctuations in an unselected population of Parkinson's disease patients attending Movement Disorders Clinic of a tertiary hospital.Eighty patients with Parkinson's disease were interviewed and data about their clinical characteristics, motor fluctuations, i.e. dyskinesia, dystonia, motor blocks
A P, Denny, M, Behari
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Motor and non‐motor fluctuations

2007
Publisher Summary Treatment of Parkinson's disease (PD) is based on dopamine replacement, either in the form of the dopamine precursor, levodopa or via directly acting dopamine receptor agonists. Early treatment of PD with these agents generally results in effective and sustained control of motor symptoms which last for several years.
Susan H, Fox, Anthony E, Lang
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L‐DOPA‐induced dyskinesias, motor fluctuations and health‐related quality of life: the COPARK survey [PDF]

European Journal of Neurology, 2017
Background and purpose: Studies assessing the correlations between L-DOPA-induced dyskinesias (LIDs) and motor fluctuations with health-related quality of life (HRQoL) in Parkinson's disease (PD) have yielded conflicting results.
Santiago Perez-Lloret, P Damier, Arnaud Delval   +2 more
exaly   +2 more sources

Gender and non motor fluctuations in Parkinson's disease: A prospective study

Parkinsonism and Related Disorders, 2016
Introduction: In Parkinson's disease (PD), non motor symptoms can fluctuate either along or irrespective to motor on/off phenomena. Prospective studies suggest that higher motor scores and levodopa dosage, younger age at onset and female gender represent
Marina Picillo, Raffaele Palladino, Marcello Moccia   +2 more
exaly   +2 more sources

Fluctuation driven ratchets: Molecular motors

Physical Review Letters, 1994
The motion of a heavily damped Brownian particle in a periodic potential subject to a dichotomously fluctuating perturbation is considered. We show that even if the net force is always zero, flow is induced by a fluctuation of the energy barrier, but only at flipping times roughly in between the adiabatic adjustment times on the left and right of the ...
, Astumian, , Bier
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Parkinson’s Disease and Motor Fluctuations

Current Treatment Options in Neurology, 2010
Many important advances for the treatment of Parkinson's disease (PD) have been made over the past decade, and quality of life has improved for most patients. Nonetheless, motor fluctuations in the form of wearing off with the re-emergence of parkinsonian symptoms and hyperkinetic movements (dyskinesias) often arise as a complication of long-term ...
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Fluctuation relations and fluctuation-response relations for molecular motors

AIP Conference Proceedings, 2011
Fluctuation relations are a set of remarkable relations obeyed by a large class of systems and arbitrarily far from equilibrium. It is interesting to discuss the implications of these relations for molecular motors, which are chemically driven enzymes.
G. Verley, D. Lacoste, Pedro L. Garrido, Joaquín Marro, F. de los Santos   +4 more
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