Morphological characteristics of motor neurons do not determine their relative susceptibility to degeneration in a mouse model of severe spinal muscular atrophy. [PDF]
PLoS ONE, 2012 Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality, resulting primarily from the degeneration and loss of lower motor neurons.
Sophie R Thomson +6 more
doaj +12 more sources
Motor neurons and the generation of spinal motor neurons diversity [PDF]
Frontiers in Cellular Neuroscience, 2014 Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS) controlling a variety of downstream targets. This function infers the existence of MN subtypes matching the identity of the targets they innervate.
Nicolas eStifani
doaj +4 more sources
Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization [PDF]
eLifeSensorimotor reflex circuits engage distinct neuronal subtypes, defined by precise connectivity, to transform sensation into compensatory behavior. Whether and how motor neuron populations specify the subtype fate and/or sensory connectivity of their pre-
Dena Goldblatt +9 more
doaj +2 more sources
Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures. [PDF]
PLoS ONE, 2014 Human motor neurons derived from embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are a potentially important tool for studying motor neuron survival and pathological cell death.
Nuno Jorge Lamas +6 more
doaj +5 more sources
Translatomic analysis of regenerating and degenerating spinal motor neurons in injury and ALS
iScience, 2021 Summary: The neuromuscular junction is a synapse critical for muscle strength and coordinated motor function. Unlike CNS injuries, motor neurons mount robust regenerative responses after peripheral nerve injuries.
Jennifer L. Shadrach +6 more
doaj +1 more source
Motor cortex analogue neurons in songbirds utilize Kv3 channels to generate ultranarrow spikes
eLife, 2023 Complex motor skills in vertebrates require specialized upper motor neurons with precise action potential (AP) firing. To examine how diverse populations of upper motor neurons subserve distinct functions and the specific repertoire of ion channels ...
Benjamin M Zemel +7 more
doaj +1 more source
DeckerMed Neurology, 2022 The motor neuron diseases (MNDs) are a family of diseases commonly categorized by their propensity to affect upper or lower motor neurons and by their mode of inheritance. The chapter provides some content on infectious MNDs caused by viral infections affecting the motor neurons in the anterior horn of the spinal cord. However, the chapter devotes most
Elena Ratti +2 more
openaire +1 more source
Motor neurons in the escape response circuit of white shrimp (Litopenaeus setiferus) [PDF]
PeerJ, 2015 Many decapod crustaceans perform escape tailflips with a neural circuit involving giant interneurons, a specialized fast flexor motor giant (MoG) neuron, populations of larger, less specialized fast flexor motor neurons, and fast extensor motor neurons ...
Zen Faulkes
doaj +2 more sources
Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits. [PDF]
, 2020 In the developing spinal cord, Onecut transcription factors control the diversification of motor neurons into distinct neuronal subsets by ensuring the maintenance of Isl1 expression during differentiation.
A Espana +36 more
core +1 more source
A size principle for recruitment of Drosophila leg motor neurons
eLife, 2020 To move the body, the brain must precisely coordinate patterns of activity among diverse populations of motor neurons. Here, we use in vivo calcium imaging, electrophysiology, and behavior to understand how genetically-identified motor neurons control ...
Anthony W Azevedo +5 more
doaj +1 more source