Results 11 to 20 of about 2,514,411 (397)

Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization [PDF]

eLife
Sensorimotor reflex circuits engage distinct neuronal subtypes, defined by precise connectivity, to transform sensation into compensatory behavior. Whether and how motor neuron populations specify the subtype fate and/or sensory connectivity of their pre-
Dena Goldblatt, Basak Rosti, Kyla Rose Hamling, Paige Leary, Harsh Panchal, Marlyn Li, Hannah Gelnaw, Stephanie Huang, Cheryl Quainoo, David Schoppik   +9 more
doaj   +2 more sources

Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924 [PDF]

Sci Rep
Sarah Lépine, Gilles Maussion, Alexandria Schneider, Angela Nauleau-Javaudin, María José Castellanos‐Montiel, Georgina Jiménez Ambriz, Dan Spiegelman, Narges Abdian, Anna Krystina Franco-Flores, Ghazal Haghi, Lale Gursu, Mathilde Chaineau, Thomas M. Durcan   +12 more
openalex   +2 more sources

Motor neurons in the escape response circuit of white shrimp (Litopenaeus setiferus) [PDF]

PeerJ, 2015
Many decapod crustaceans perform escape tailflips with a neural circuit involving giant interneurons, a specialized fast flexor motor giant (MoG) neuron, populations of larger, less specialized fast flexor motor neurons, and fast extensor motor neurons ...
Zen Faulkes
doaj   +2 more sources

Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons

Nature Neuroscience, 2020
The spinal cord is a fascinating structure that is responsible for coordinating movement in vertebrates. Spinal motor neurons control muscle activity by transmitting signals from the spinal cord to diverse peripheral targets.
Jacob A. Blum, Sandy L. Klemm, J. Shadrach, Kevin A. Guttenplan, Lisa Nakayama, Arwa S. Kathiria, Phuong Hoang, Olivia Gautier, Julia A. Kaltschmidt, W. Greenleaf, A. Gitler   +10 more
semanticscholar   +1 more source

Calcium imaging of CPG-evoked activity in efferent neurons of the stick insect. [PDF]

PLoS ONE, 2018
The stick insect is a well-established experimental animal to study the neural basis of walking. Here, we introduce a preparation that allows combining calcium imaging in efferent neurons with electrophysiological recordings of motor neuron activity in ...
Jens Goldammer, Charalampos Mantziaris, Ansgar Büschges, Joachim Schmidt   +3 more
doaj   +1 more source

rAAV2-Retro Enables Extensive and High-Efficient Transduction of Lower Motor Neurons following Intramuscular Injection

Molecular Therapy: Methods & Clinical Development, 2020
The motor system controls muscle movement through lower motor neurons in the spinal cord and brainstem. Lower motor neurons are efferent neurons in the central nervous system (CNS) characterized by axonal projections that reach specific targets in the ...
Zhilong Chen, Guoqing Fan, Anan Li, Jing Yuan, Tonghui Xu   +4 more
doaj   +1 more source

iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons

Cell Reports, 2023
Summary: Motor neuron degeneration, the defining feature of amyotrophic lateral sclerosis (ALS), is a primary example of cell-type specificity in neurodegenerative diseases.
Aaron Held, Michelle Adler, Christine Marques, Charles Jourdan Reyes, Amey S. Kavuturu, Ana R.A.A. Quadros, I. Sandra Ndayambaje, Erika Lara, Michael Ward, Clotilde Lagier-Tourenne, Brian J. Wainger   +10 more
doaj   +1 more source

Aging alters mechanisms underlying voluntary movements in spinal motor neurons of mice, primates, and humans

JCI Insight, 2023
Spinal motor neurons have been implicated in the loss of motor function that occurs with advancing age. However, the cellular and molecular mechanisms that impair the function of these neurons during aging remain unknown. Here, we show that motor neurons
Ryan W. Castro, Mikayla C. Lopes, Robert E. Settlage, Gregorio Valdez   +3 more
doaj   +1 more source

Motor neurone disease [PDF]

BMJ, 2011
Diane Sackett experienced the first symptoms of motor neurone disease in 2004, and died in September 2009. Diane’s husband, Brian, was her main carer.
Brian, Sackett, Mohamed, Sakel
openaire   +2 more sources

GABAergic motor neurons bias locomotor decision-making in C. elegans

Nature Communications, 2020
Motor neurons are generally considered to be passive receivers of commands from other neurons. However, this study shows that motor neurons may shape locomotor behaviour by regulating premotor neurons, and that premotor neurons serve to integrate ...
Ping Liu, Bojun Chen, Zhao-Wen Wang
doaj   +1 more source